A5060231540- Cancer-related molecular mechanisms research
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Medicinal Plant Pharmacodynamics Research
- Pleural and Pulmonary Diseases
- Bone and Dental Protein Studies
- Metabolism, Diabetes, and Cancer
- Polysaccharides and Plant Cell Walls
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Neurogenesis and neuroplasticity mechanisms
- Insect Resistance and Genetics
- Cannabis and Cannabinoid Research
- Lipid metabolism and biosynthesis
- Plant Genetic and Mutation Studies
- Immune Cell Function and Interaction
- Pancreatitis Pathology and Treatment
- Circular RNAs in diseases
- Amoebic Infections and Treatments
- Cytokine Signaling Pathways and Interactions
- Genetics, Aging, and Longevity in Model Organisms
- Nerve injury and regeneration
- Effects and risks of endocrine disrupting chemicals
- Metal-Organic Frameworks: Synthesis and Applications
- RNA Research and Splicing
- Carcinogens and Genotoxicity Assessment
Youjiang Medical College for Nationalities
2008-2024
Affiliated Hospital of Youjiang Medical University for Nationalities
2014-2024
Huazhong Agricultural University
2023
Capital Medical University
2020
Abstract Background There is growing evidence of the role long non-coding RNAs (lncRNAs) in cervical cancer (CC). The objective was to discuss whether exosomal lncRNA HNF1A-AS1 impacted drug resistance CC via binding microRNA-34b (miR-34b) and regulating TUFT1 expression. Methods expression normal epithelial cells, cisplatin (DDP)-sensitive cell line (HeLa/S) DDP-resistant (HeLa/DDP) cells were detected. HeLa/S HeLa/DDP interfered with determine IC 50 , proliferation, colony formation...
In this study, we investigated the effects of calycosin on breast cancer cell progression and their underlying mechanisms. Calycosin dose- time-dependently inhibited proliferation, migration, invasion by T47D MCF-7 cells downregulating basic leucine zipper ATF-like transcription factor (BATF) expression. Moreover, BATF promoted migration invasiveness increasing TGFβ1 mRNA protein levels. Bioinformatics analysis, dual luciferase reporter assays, chromatin immunoprecipitation assays confirmed...
Abstract Background Oocyte quality is critical for the mammalian reproduction due to its necessity on fertilization and early development. During aging, declined oocytes showing with organelle dysfunction oxidative stress lead infertility. AMP-activated protein kinase (AMPK) a serine/threonine which important energy homeostasis metabolism. Little known about potential relationship between AMPK oocyte aging. Results In present study we reported that was related low of under post ovulatory...
Background: The incidence of obesity-associated decline in male fertility has increased over the years. Lycium barbarum polysaccharide (LBP), a natural plant extracted from Chinese herb L. shown promising therapeutic effects overcoming same. Aim: This study aimed to investigate protective effect LBP on testes obese mice. Methods: Following administration high-fat diet-induced mice for 35 days, serum, sperm, and testis samples were obtained subsequent experiments. Biochemical analysis sex...
Background: Lycium barbarum polysaccharide (LBP) has been reported to contribute the recovery of male hypogonadism and infertility. Aim: The aim current study was investigate underlying mechanisms LBP on infertility recovery. Methods: Recently, it is that cell apoptosis mediated by endoplasmic reticulum stress (ERS) distinguished from death reporters mitochondria pathway, which could induce independently. possible signaling were investigated using diversified molecular biology techniques,...
Multiple morphological abnormalities of the sperm flagellum (MMAF) have been reported to be an important cause male infertility and reflect a heterogeneous genetic disorder. Previous studies identified dozens candidate pathogenic genes for MMAF, but aetiology in approximately 50% cases remains unexplained. The present study aimed identify novel potentially gene variants MMAF. A Chinese family with 32-year-old infertile proband presenting MMAF was recruited, morphology patient examined by...
Abstract Background Delay in diagnosis and treatment worsens the disease clinical outcomes, which further enhances transmission of tuberculosis (TB) community. Therefore, this study aims to assess delay its associated factors among childhood pleural TB patients China. Methods Between January 2006 December 2019, consecutive aged ≤15 years with definite or possible were included for analysis. Treatment duration was defined as time interval from onset symptoms initiation stratified into two...
Background Although abnormal cerebrospinal fluid (CSF) protein can be used to predict the outcome of tuberculous meningitis (TBM) and diagnose TBM, normal CSF remains a concern in patients with TBM. This retrospective study aimed assess clinical characteristics associated protein, resolve dilemma management childhood TBM.Methods Between January 2006 December 2019, consecutive child (≤15 years old, diagnosis tested for protein) were included analysis. was on chemistry analyzer using...
Na+/H+ exchanger regulatory factor 1 (NHERF1) is an important scaffold protein participates in the modulation of a variety intracellular signal pathways. NHERF1 was able to enhance effects chemo-drugs breast and cervical cancer cells. Anaplastic lymphoma kinase (ALK) fusion mutations are validated molecules targeted therapy lung cancers, where crizotinib can be used as specific inhibitor suppress tumor progression. However, due less frequent occurrence ALK complexity for factors determine...
Asthenozoospermia is the most common factor of male infertility, mainly caused by multiple morphological abnormalities sperm flagella (MMAF) and primary ciliary dyskinesia (PCD). Previous studies have shown that genetic factors may contribute to MMAF PCD. The study aimed identify novel potentially pathogenic gene mutations in a Chinese infertile man with PCD-like phenotypes.
Abstract Background/Aim: In recent years, there has been increasing evidence for the function of long non-coding RNA (lncRNA) in nasopharyngeal carcinoma (NPC).. We aim to delve into position lncRNA HOTAIR, together with EZH2, E-cadherin and H3K27me3 NPC explore related mechanisms. Methods RT-qPCR western blot analysis were carried out detecting expression tissues cells. Moreover, correlations between HOTAIR EZH2 clinicopathological characteristics prognosis patients observed. cell...