Adam J. Schwartz
A5040618859- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Sarcoma Diagnosis and Treatment
- Dementia and Cognitive Impairment Research
- Knee injuries and reconstruction techniques
- Functional Brain Connectivity Studies
- Alzheimer's disease research and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Bone Tumor Diagnosis and Treatments
- Healthcare Policy and Management
- Hip and Femur Fractures
- Primary Care and Health Outcomes
- Pelvic and Acetabular Injuries
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Infectious Diseases and Tuberculosis
- Patient Satisfaction in Healthcare
- Management of metastatic bone disease
- Musculoskeletal synovial abnormalities and treatments
- Genetic Associations and Epidemiology
- Orthopedic Surgery and Rehabilitation
- Neurological Disease Mechanisms and Treatments
- Urological Disorders and Treatments
- Facial Trauma and Fracture Management
University of South Florida
2023-2024
Mayo Clinic Hospital
2012-2022
Mayo Clinic in Florida
2013-2022
WinnMed
2013-2022
BRAC USA
2022
Mayo Clinic in Arizona
2010-2022
Eli Lilly (United States)
2015-2022
University of Alabama
2016-2020
University of Minnesota
2020
University of California, San Francisco
2020
Abstract Multifactorial mechanisms underlying late-onset Alzheimer’s disease (LOAD) are poorly characterized from an integrative perspective. Here spatiotemporal alterations in brain amyloid-β deposition, metabolism, vascular, functional activity at rest, structural properties, cognitive integrity and peripheral proteins levels relation to LOAD progression. We analyse over 7,700 images tens of plasma cerebrospinal fluid biomarkers the Disease Neuroimaging Initiative (ADNI). Through a...
Abstract Brain iron elevation is implicated in Alzheimer’s disease (AD) pathogenesis, but the impact of on outcomes has not been previously explored a longitudinal study. Ferritin major storage protein body; by using cerebrospinal fluid (CSF) levels ferritin as an index, we whether brain status impacts Disease Neuroimaging Initiative (ADNI) cohort. We show that baseline CSF were negatively associated with cognitive performance over 7 years 91 cognitively normal, 144 mild impairment (MCI) and...
There is considerable debate whether Alzheimer's disease (AD) originates in basal forebrain or entorhinal cortex. Here we examined longitudinal decreases and cortex grey matter volume were interdependent sequential. In a large cohort of age-matched older adults ranging from cognitively normal to AD, demonstrate that predicts degeneration. Models parallel degeneration origin received negligible support. We then integrated volumetric measures with an amyloid biomarker sensitive pre-symptomatic...
Diagnosing a periprosthetic joint infection (PJI) requires complex approach using various laboratory and clinical criteria. A novel to diagnosing these infections uses synovial fluid biomarkers. Alpha defensin-1 (AD-1) is one such synovial-fluid biomarker. However little known about the performance of AD-1 assay in diagnosis PJI.We sought (1) determine sensitivity specificity population patients being evaluated for PJI, Musculoskeletal Infection Society (MSIS) criteria as reference standard,...
Significance Alzheimer’s disease (AD) affects 10% of the elderly population. The remains poorly understood with no cure. main symptom is memory loss, but other symptoms might include impaired executive function (ability to plan and accomplish goals; e.g., grocery shopping). severity behavioral brain atrophy (gray matter loss) can vary widely across patients. This variability complicates diagnosis, treatment, prevention. A mathematical model reveals distinct patterns, explaining variation in...
Fillingham, Yale A. MD; Della Valle, Craig J. Suleiman, Linda I. Springer, Bryan D. Gehrke, Thorsten Bini, Stefano Segreti, John Chen, Antonia F. MD, MBA; Goswami, Karan Tan, Timothy L. Shohat, Noam Diaz-Ledezma, Claudio Schwartz, Adam Parvizi, Javad MD Author Information
Advocates of newer implant designs cite high rates aseptic loosening and failure as reasons to abandon traditional cemented endoprosthetic reconstruction the distal femur.We asked whether newer, modular femoral components had improved survivorship compared with older, custom-casted designs.We retrospectively reviewed 254 patients who underwent reconstruction. We excluded two cementless implants, 27 expandable prostheses, 39 a nontumor diagnosis. This left 186 patients: 101 older custom...
Wound complications following resection of a localized soft tissue sarcoma have been associated with lower extremity location, large tumor volume, and use preoperative radiation. Some these wounds, however, show the potential for healing local wound care nonsurgical techniques. We are unaware any published data establishing factors nonhealing wounds that ultimately treated or free vascularized transfer.The purpose this study was to determine variables development significant complication...
Significance Neuroimaging has largely focused on two goals: mapping associations between neuroanatomical features and phenotypes building individual-level prediction models. This paper presents a complementary analytic strategy called morphometricity that aims to measure the signatures of different phenotypes. Inspired by prior work heritability, we define as proportion phenotypic variation can be explained brain morphology (e.g., captured structural MRI). In dawning era large-scale datasets...
As the life expectancy of patients with musculoskeletal tumors improves, long-term studies endoprosthetic reconstructions are necessary to establish realistic expectations for implants and compare them other reconstruction approaches.(1) What is survival cemented bipolar proximal femoral replacements? (2) How does prosthesis patient among Stage I, II, III disease? (3) Do modular outperform custom-built prostheses? (4) some replacements require conversion THA?We retrospectively reviewed all...
It has been argued that internal hemipelvectomy without reconstruction of the pelvic ring leads to poor ambulation and inferior patient acceptance. To determine accuracy this contention, we posed following questions: First, how effectively does a typical ambulate procedure? Second, what is functional capacity hemipelvectomy? In spring 2006, obtained video documentation eight patients who had undergone resection arthroplasty hemipelvis seen in our clinic during routine clinical followup. The...
Abstract Little is known about how genetic variation contributes to neuroanatomical variability, and whether particular genomic regions comprising genes or evolutionarily conserved elements are enriched for effects that influence brain morphology. Here, we examine imaging single-nucleotide polymorphisms (SNPs) data from ∼2,700 individuals. We show a substantial proportion of in cortical surface area explained by additive SNPs dispersed throughout the genome, with larger heritable effect...
Debridement and implant retention (DAIR) has variable success as a treatment for acute periprosthetic joint infection (PJI), with generally poor outcomes reported in the literature
The few available studies documenting the long-term survival of cemented proximal tibial endoprostheses for musculoskeletal tumors do not differentiate between stem designs or patient diagnosis. There is wide variation in rates reported, possibly a result this heterogeneity population and implant design.We therefore asked: (1) How long last? (2) What typical functional after replacement? And (3) what are short- complications associated with endoprosthetic reconstruction tibia, particularly...
A third-generation TKA system was designed to address problems encountered with earlier designs including a high rate of patellofemoral complications. At minimum 5 years, we previously reported survivorship 98.7% using revision for any reason as the endpoint cohort that includes patients described in this report. That unique tibial component uses four short pegs fixation used subset undergoing cruciate-retaining and femoral components were precoated polymethylmethacrylate.We now report...