A5054936862- Cancer, Lipids, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Fatty Acid Research and Health
- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Cellular Mechanics and Interactions
- Traumatic Brain Injury Research
- Prostate Cancer Treatment and Research
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Traumatic Brain Injury and Neurovascular Disturbances
- Peroxisome Proliferator-Activated Receptors
- Ovarian cancer diagnosis and treatment
- RNA Research and Splicing
- Research in Social Sciences
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Chromatin Remodeling and Cancer
- Ferroptosis and cancer prognosis
- Cognitive and developmental aspects of mathematical skills
- Spondyloarthritis Studies and Treatments
University of Turku
2011-2024
Åbo Akademi University
2024
Turku University Hospital
2011-2021
VTT Technical Research Centre of Finland
1988-2012
Turku Centre for Biotechnology
2011-2012
BG Klinikum Hamburg
2011
University of California, Davis
2011
University of Cambridge
2011
German Breast group
2011
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Abstract Activation of lipid metabolism is an early event in carcinogenesis and a central hallmark many cancers. However, the precise molecular composition lipids tumors remains generally poorly characterized. The aim present study was to analyze global profiles breast cancer, integrate results protein expression, validate findings by functional experiments. Comprehensive lipidomics conducted 267 human tissues using ultraperformance liquid chromatography/ mass spectrometry. products de novo...
Abstract Due to its dynamic nature, the evolution of cancer cell-extracellular matrix (ECM) crosstalk, critically affecting metastasis and treatment resistance, remains elusive. Our results show that platinum-chemotherapy itself enhances resistance by progressively changing cell-intrinsic adhesion signaling cell-surrounding ECM. Examining ovarian high-grade serous carcinoma (HGSC) transcriptome histology, we describe fibrotic ECM heterogeneity at primary tumors distinct metastatic sites,...
// Laura Lehtinen 1 , Kirsi Ketola Rami Mäkelä John-Patrick Mpindi 2 Miro Viitala Olli Kallioniemi and Kristiina Iljin Medical Biotechnology, VTT Technical Research Centre of Finland Turku for University Turku, Institute Molecular Medicine (FIMM), Helsinki, Correspondence: Lehtinen, email: Keywords : Breast cancer, vimentin, MTHFD2 Received December 09, 2012, Accepted 15, Published 17, 2012 Abstract Vimentin is an intermediate filament protein, with a key role in the epithelial to...
Prostate cancer is the second leading cause of mortality in men developed countries. Due to heterogeneous nature disease, design novel personalized treatments required achieve efficient therapeutic responses. We have recently identified phospholipase 2 group VII (PLA2G7) as a potential drug target especially ERG oncogene positive prostate cancers. Here, expression profile PLA2G7 was studied 1137 and 409 adjacent non-malignant tissues using immunohistochemistry validate its biomarker putative...
Combining cytotoxic chemotherapy or novel anticancer drugs with T-cell modulators holds great promise in treating advanced cancers. However, the response varies depending on tumor immune microenvironment (TIME). Therefore, there is a clear need for pharmacologically tractable models of TIME to dissect its influence mono- and combination treatment at individual level.
Cancer cells can obtain their ability to invade and metastasise by undergoing epithelial-to-mesenchymal transition (EMT). Exploiting this mechanism of cellular plasticity, malignant remodel actin cytoskeleton down-regulate proteins needed for cell-cell contacts. The mechanisms cytoskeletal reorganisation resulting in mesenchymal morphology increased invasive potential are poorly understood. Actin nucleating formins have been implicated as key players EMT. Here, we analysed which altered...
Poor chemotherapy response remains a major treatment challenge for high-grade serous ovarian cancer (HGSC). Cancer stem cells are the contributors to relapse and failure as they can survive conventional therapy. Our objectives were characterise stemness features in primary patient-derived cell lines, correlate markers with clinical outcome test of our both exploratory drugs. Tissue ascites samples, treatment-naive and/or after neoadjuvant chemotherapy, prospectively collected. Primary cells,...
Aneuploidy is among the most obvious differences between normal and cancer cells. However, mechanisms contributing to development maintenance of aneuploid cell growth are diverse incompletely understood. Functional genomics analyses have shown that aneuploidy in cells correlated with diffuse gene expression signatures can arise by a variety mechanisms, including cytokinesis failures, DNA endoreplication, possibly through polyploid intermediate states. To identify molecular processes...
Abstract The analysis of extracellular vesicles (EVs) typically requires tedious and time-consuming isolation process from bio-fluids. We developed a nanoparticle-based time resolved fluorescence immunoassay (NP-TRFIA) that uses biotinylated antibodies against the proteins tetraspanin family tumor-associated antigens for capturing EVs urine samples cell culture supernatants without need isolation. captured-EVs were detected either with Eu 3+ -chelate or -doped labels conjugated to...
Breast cancer is the most frequent and leading cause of cancer-related deaths in women worldwide. The prognosis breast tightly correlated with degree spread beyond primary tumour. Arachidonic acid (AA) prostaglandin E(2) (PGE(2)) are known to regulate tumour metastasis enabling epithelial-mesenchymal transition (EMT). However, detailed role 15-hydroxyprostaglandin dehydrogenase (HPGD), key enzyme degrading , remains unclear cancer. Here, we show that HPGD mRNA overexpressed a subset clinical...
Abstract Background The prognosis of glioblastoma remains poor, related to its diffuse spread within the brain. There is an ongoing search for molecular regulators this particularly invasive behavior. One approach look actin regulating proteins that might be targeted by future anti-cancer therapy. formin family orchestrates rearrangement cytoskeleton in multiple cellular processes. Recently, mDia1 and mDia2 were shown expressed vitro, their function could modified small molecule agonists....
Breast cancer is the leading cause of cancer-related deaths in women due to distinct subtypes associated with early recurrence and aggressive metastatic progression. High lipoprotein-associated phospholipase A2 (PLA2G7) expression has previously been disease metastasis prostate cancer. Here, we explore pattern functional role PLA2G7 breast First, a bioinformatic analysis genome-wide gene data from 970 samples was carried out evaluate mRNA Second, profile studied 1042 including 89 matched...
Abstract While host immune response is likely to be important for the prognosis of gastric cancer patients, detailed information on T lymphocyte infiltration in different subtypes lacking. Here, we studied presence CD3, CD8, and FOXP3 (Forkhead box p3) expressing lymphocytes a retrospective cohort 190 intestinal gastroesophageal adenocarcinomas. The cancers represented four distinct molecular subtypes: Epstein-Barr virus–positive (EBV+), mismatch-repair-deficient (MMR-D), aberrant TP53,...
Preoperative diagnostics of ovarian neoplasms rely on ultrasound imaging and the serum biomarkers CA125 HE4. However, these markers may be elevated in non-neoplastic conditions fail to identify most non-serous epithelial cancer subtypes. The objective this study was histotype-specific for mucinous cancer. candidate genes with histotype specific expression profile were identified from publicly available gene-expression databases further silico data mining performed utilizing MediSapiens...
Abstract Erythropoietin producing hepatocellular (Eph) receptors and their membrane-bound ligands ephrins are variably expressed in epithelial cancers, with context-dependent implications to both tumor-promoting -suppressive processes ways that remain incompletely understood. Using ovarian cancer tissue microarrays longitudinally collected patient cells, we show here ephrinA5/ EFNA5 is specifically overexpressed the most aggressive high-grade serous carcinoma (HGSC) subtype, increased HGSC...
Expression of regenerating islet-derived protein 4 (REG4), a secretory involved in cell differentiation and proliferation, is upregulated inflammatory bowel diseases many gastrointestinal malignancies. The prognostic significance its expression pancreatic ductal adenocarcinoma unknown. Our aim was to investigate tumor tissue serum REG4 patients. We also evaluated as control the diagnostic value level patients with chronic pancreatitis. Immunohistochemical 154 surgical specimens 130 samples...
Gastric cancer (GC) is the third most common cause of death. Intestinal type GC a molecularly diverse disease. Formins control cytoskeletal processes and have been implicated in progression many cancers. Their clinical significance remains unclear. Here, we characterize expression formin proteins FHOD1 FMNL1 intestinal tissue samples investigate their association with parameters, molecular subtypes intratumoral T lymphocytes.The prognostic mRNA was studied Kaplan-Meier analyses an online...
Abstract Ductal carcinoma in situ (DCIS) is the most common precancerous finding mammography screens. DCIS generally has a good prognosis, and only 20-25% of cases progress to invasive breast (IBC) even if left untreated. Breast pathologists radiologists have suggested that there are currently more than one kind under same diagnosis. A subset with reduced survival rate associated casting-type calcifications can be histologically detected within closely packed, contorted, newly formed ducts,...