A5079807417- Schizophrenia research and treatment
- Mental Health and Psychiatry
- Psychosomatic Disorders and Their Treatments
- Psychiatric care and mental health services
- Cardiac Health and Mental Health
- Psychotherapy Techniques and Applications
- Bipolar Disorder and Treatment
- Child Abuse and Trauma
- Child and Adolescent Psychosocial and Emotional Development
- Research in Social Sciences
- Obsessive-Compulsive Spectrum Disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Mental Health Treatment and Access
- Health, psychology, and well-being
- Migration, Health and Trauma
- Treatment of Major Depression
- Resilience and Mental Health
- Suicide and Self-Harm Studies
- Heart Rate Variability and Autonomic Control
- Cancer-related cognitive impairment studies
- Music Therapy and Health
- Digital Mental Health Interventions
- Tryptophan and brain disorders
- Cancer survivorship and care
- Autoimmune Neurological Disorders and Treatments
University of Turku
2010-2023
Turku University Hospital
2009-2023
Authorised Association Consortium
2022
Finnish Society of Sciences and Letters
2019
University of Cologne
2008
University of Birmingham
2008
Tampere University
2008
University of Helsinki
2008
Tampere University Hospital
2008
Turku City Hospital
1986
Animal studies have indicated that the nigrostriatal dopaminergic system is involved in central pain modulation. In a recent positron emission tomography (PET) study, we demonstrated presynaptic dysfunction of pathway burning mouth syndrome, which chronic state. The objective present study was to examine striatal dopamine D1 and D2 receptors these patients. We used 11C-NNC 756 11C-raclopride receptor binding PET ten patients 11 healthy controls. Patients underwent structured psychiatric...
Background: Childhood adversities and trauma (CAT) are associated with adult mental disorders. Nevertheless, although CAT of different domains mostly co-occurs, co-morbidity is common, the associations between disorders, when taking these interrelations into account, not well known.Aims: We aimed to study differential five core current axis-I consideration their interrelations.Methods: Four hundred fifteen outpatients attending primary (n = 255) psychiatric care 160) were assessed Trauma...
BackgroundThere is increasing evidence that a history of childhood abuse and neglect not uncommon among individuals who experience mental disorder trauma experiences are associated with adult psychopathology. Although several interview self-report instruments for retrospective assessment have been developed, many focus on sexual (SexAb) rather than multiple types or adversity.MethodsWithin the European Prediction Psychosis Study, Trauma Distress Scale (TADS) was developed as new distressing...
Schizotypal features indicate proneness to psychosis in the general population. It is also possible that they increase transition (TTP) among clinical high-risk patients (CHR). Our aim was investigate whether schizotypal predict TTP CHR patients.In EPOS (European Prediction of Psychosis Study) project, 245 young help-seeking were prospectively followed for 18 months and their identified. At baseline, subjects assessed with Personality Questionnaire (SPQ). Associations between SPQ items its...
Approaches are needed to stratify individuals in early psychosis stages beyond positive symptom severity investigate specificity related affective and normative variation validate solutions with premorbid, longitudinal, genetic risk measures.
Abstract Aim Traumatic childhood experiences are associated with psychotic illness and frequently reported in patients at clinical high risk ( CHR ) for psychosis. Moreover, deteriorating premorbid functioning from childhood, through adolescence, is related to greater severity of overall symptomatology poorer outcomes We studied the prevalence traumatic adjustment their association each other psychosis normal control subjects NCS s). Methods A total 20 30 s aged 14 35 participated present...
In patients with schizophrenia, premorbid psychosocial adjustment is an important predictor of functional outcome. We studied outcome in young clinical high-risk (CHR) and how this was predicted by their childhood to adolescence adjustment.In all, 245 help-seeking CHR were assessed the Premorbid Adjustment Scale, Structured Interview for Prodromal Syndromes (SIPS) Schizophrenia Proneness Instrument (SPI-A). The SIPS assesses positive, negative, disorganised, general symptoms, Global...
In addition to psychiatric disorders, childhood adversities may increase the risk of suicidal behavior. previous studies, effects clinical co-morbidity and overlap has rarely been taken into account.The study aims search associations diagnoses trauma (CAT) with suicide risk.Altogether 415 adult patients attending primary outpatient care filled in Trauma Distress Scale, including assessment five core CAT domains (emotional, physical sexual abuse, emotional neglect). The patients' current...
Serum cholesterol fractions and triglycerides were determined in 68 female hospital patients over 90 years of age with senile dementia Alzheimer type (AD; n=22) multi-infarct (MID; n=23) or without (n=23). There no significant differences serum HDL levels between the three groups, but ratio high-density lipoprotein (HDLC) to total choloesterol was lower MID than dementia. In all groups concentrations cholesterol, low-density (LDLC) relatively low concentration HDLC normal. The...
Depression is not treated adequately after myocardial infarction (MI). This study evaluates the interpersonal counselling (IPC) implemented by a registered nurse on outcomes for depressive symptoms and distress in MI patients.We studied patients (n = 103) randomized into intervention group 51) control 52) hospital at 6 18 months discharge using validated questionnaires, Beck's Inventory (BDI) Symptom Checklist-25 (SCL-25).During 18-month follow-up, decreased statistically significantly (P...
Abstract Cognitively impaired and spared patient subgroups were identified in psychosis depression, clinical high-risk for (CHR). Studies suggest differences underlying brain structural functional characteristics. It is unclear whether cognitive are transdiagnostic phenomena early stages of psychotic affective disorder which can be validated on the neural level. Patients with recent-onset (ROP; N = 140; female 54), depression (ROD; 130; 73), CHR ( 128; 61) healthy controls (HC; 270; 165)...
Objective: The objective of the study was to investigate prevalence depressive symptoms and self‐reported psychiatric treatment after myocardial infarction. Method: Depressive medication were studied in 85 consecutive acute infarction patients during 18 months follow‐up. assessed using Beck Depression Inventory (BDI). Results: proportion with (BDI 10) 21.2% while hospital, 30.0% at 6 33.9% months. At months, none receiving adequate antidepressive medication. There eight BDI scores...
Alexithymia is a personality trait associated with difficulties in identifying feelings, describing feelings to other people, constricted imaginal processes, and an externally oriented cognitive style. It has been found be features that may cause interpersonally avoidant behavior interpersonal problems. The present study explored, sample of primary care patients (N = 491), whether alexithymia mobile phone usage, the perceived quality quantity human relationships mediate its effect. Even...
Previous studies show conflicting results on the role of weak sense coherence (SOC) as a risk factor for depression.The aim this work was to study whether SOC predicts depressive symptoms in non-depressive population sample short or long perspective.Participants without (n = 1645) Finnish Outcomes Depression International Network (ODIN) were assessed at 1-year and 9-year follow-up. Depressive by Beck Inventory (BDI), 13-item Orientation Life Questionnaire (SOC-13). Logistic regression...
Aim. To evaluate the effects of interpersonal counselling on health‐related quality life after myocardial infarction. Background. Depression is a risk factor for poor Interpersonal seems to reduce depressive symptoms and distress Methods. Myocardial infarction patients ( n = 103) were randomised into an intervention group 51) with 1–6 (mean 4·6) counselling‐sessions focusing managing control 52). Health‐related was measured EuroQol‐5D (EQ‐5D) in hospital, at six 18 months discharge. Results....
Functional recovery of patients with clinical and subclinical psychosis is associated clinical, neuropsychological developmental factors. Less known about how these factors predict functional outcomes in the same models. We investigated their predictors first-episode (FEP) or a confirmed nonconfirmed high risk (CHR-P vs. CHR-N).Altogether, 130 FEP, 60 CHR-P 47 CHR-N were recruited extensively examined at baseline (T0) 9 (T1) 18 (T2) months later. Global Assessment Functioning (GAF) T0, T1 T2...
Abstract Goal We studied the prevalence of and association between psychotic symptoms childhood trauma experiences in primary care patients compared with psychiatric patients. Patients methods note 911 over 16 years age filled a questionnaire including list lifetime Composite International Diagnostic Interview (CIDI) Trauma Distress Scale (TADS). Prevalence correlations stressful were calculated. Association sum CIDI TADS score was analysed by Anova. Results In care, more than half had at...
Background and Objectives We aimed to study how five childhood adversities trauma (CAT) core domains: emotional abuse (EmoAb), physical (PhyAb), sexual (SexAb), neglect (EmoNeg), (PhyNeg), associate with alcohol problems (APs), whether there are any gender differences in these associations. Methods Altogether, 690 adult participants drawn from the general population completed a mailed questionnaire, including distress scale, as an indicator of CAT, questions concerning sociodemographic...