A5013679532- Plant Virus Research Studies
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Gut microbiota and health
- Viral Infections and Immunology Research
- Autism Spectrum Disorder Research
- HIV-related health complications and treatments
- Bacteriophages and microbial interactions
- Genomic variations and chromosomal abnormalities
- Herpesvirus Infections and Treatments
- Animal Disease Management and Epidemiology
- Quinazolinone synthesis and applications
- Animal Virus Infections Studies
- Environmental DNA in Biodiversity Studies
- Hepatitis C virus research
- Reproductive tract infections research
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- Evolution and Genetic Dynamics
- Metabolomics and Mass Spectrometry Studies
- Nail Diseases and Treatments
- Virus-based gene therapy research
- CRISPR and Genetic Engineering
- Phenothiazines and Benzothiazines Synthesis and Activities
- Wnt/β-catenin signaling in development and cancer
University of Cagliari
2010-2022
The University of Texas at Austin
2022
Inflammatory bowel disease (IBD) is a chronic inflammatory of the gastrointestinal tract uncertain origin, which includes ulcerative colitis (UC) and Crohn's (CD). The composition gut microbiota may change in IBD affected individuals, but whether dysbiosis cause or consequence processes intestinal tissue still unclear. Here, metabolites stool 183 subjects (82 UC, 50 CD, 51 healthy controls) were determined. content microbiological profiles significantly different between subjects. In group,...
Clustered protocadherins (PCDHs) map in tandem at human chromosome 5q31 and comprise three multi-genes clusters: α-, β- γ-PCDH. The expression of this cluster consists a complex mechanism involving DNA hub formation through DNA-CCTC binding factor (CTCF) interaction. Methylation alterations can affect interaction, leading to transcriptional dysregulation. In cancer, clustered PCDHs undergo long-range epigenetic silencing by hypermethylation.In study, we detected frequent methylation CpG...
Autism spectrum disorders (ASDs) are a group of neurodevelopmental with high heritability, although their underlying genetic factors still largely unknown. Here we present comprehensive characterization two ASD siblings from Sardinia by genome-wide copy number variation analysis and whole exome sequencing (WES), to identify novel alterations associated this disorder. Single nucleotide polymorphism (SNP) array data revealed rare microdeletion involving CAPG, ELMOD3, SH2D6 genes, in both...
Although much is known of the molecular mechanisms virus infection within cells, substantially less understood about within-host infection. Such knowledge key to understanding how viruses take up residence and transmit infectious virus, in some cases throughout life host. Here, using murine polyomavirus (muPyV) as a tractable model, we monitor parallel infections thousands differentially barcoded single In individual mice, show that numerous (>2600) establish are maintained for long periods...
The virus-encoded RNA-dependent RNA polymerase (RdRp) has emerged as a primary target in the search for selective inhibitors of Flaviviridae. Recently, we reported on inhibition, cell-based assays, both BVDV (EC50 = 0.80 ± 0.06 μM) and HCV 1.11 0.15 by 2-{1-[2-(2,4-dimethoxyphenyl)-1H-benzimidazol-5-yl]ethylidene}hydrazinecarbothioamide (227G). Here show that, enzyme assays with recombinant enzymes, 227G inhibits, dose-dependent manner, RdRp (IC50 0.0020 0.0004 0.40 0.04 μM). Furthermore,...
Torque teno viruses (TTVs) are a large group of vertebrate-infecting small with circular single-stranded DNA, classified in the Anelloviridae family. In swine, two genetically distinct species, sus virus 1a (TTSuV1a) and 1b (TTSuV1b) currently grouped into genus Iotatorquevirus. More recently, novel named k2b (TTSuVk2b), has been included k2a (TTSuVk2a) Kappatorquevirus. present study, TTSuV1 (TTSuV1a TTSuV1b), TTSuVk2a TTSuVk2b prevalence was evaluated 721 serum samples healthy pigs from...
Abstract Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by high heritability. It known that genetic factors contribute to ASD pathogenesis. In particular, copy number variants (CNVs) are involved in susceptibility and can affect gene expression regulation. 2p11.2 microdeletions encompassing ELMOD3 , CAPG SH2D6 genes have been described four unrelated families. The present study revealed this microdeletion responsible for the production chimeric...
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The concept of a nucleic acid barcode applied to pathogen genomes is easy grasp and the many possible uses are straightforward. But implementation may not be easy, especially when growing through multiple generations or assaying long-term. potential problems include: might alter fitness, accumulate mutations, construction marked pathogens result in unintended barcodes that as designed. Here, we generate approximately 5,000 randomized genome prototypic small DNA virus murine polyomavirus. We...
ABSTRACT The concept of a nucleic acid barcode applied to pathogen genomes is easy grasp and the many possible uses are straightforward. But implementation may not be easy, especially when growing through multiple generations or assaying long-term. potential problems include: might alter fitness, accumulate mutations, construction marked pathogens result in unintended barcodes that as designed. Here, we generate approximately 5000 randomized genome prototypic small DNA virus murine...