A5024774568- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Transcranial Magnetic Stimulation Studies
- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Neuroinflammation and Neurodegeneration Mechanisms
- Photoreceptor and optogenetics research
- Neural and Behavioral Psychology Studies
- Neurogenesis and neuroplasticity mechanisms
- Neurology and Historical Studies
- Tuberous Sclerosis Complex Research
- Circadian rhythm and melatonin
- Mitochondrial Function and Pathology
- Vestibular and auditory disorders
- History of Medicine Studies
- Neuroendocrine regulation and behavior
- Muscle activation and electromyography studies
- PI3K/AKT/mTOR signaling in cancer
- Hearing Loss and Rehabilitation
- Genetics and Neurodevelopmental Disorders
- Retinal Development and Disorders
- Olfactory and Sensory Function Studies
- Pain Mechanisms and Treatments
- Sleep and Wakefulness Research
- Glioma Diagnosis and Treatment
University of Verona
2019-2024
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
2024
New York State Psychiatric Institute
2019
Columbia University
2019
Auburn University
2019
American Academy in Rome
2019
New York Psychoanalytic Society and Institute
2019
University of Turin
2013-2018
Istituti di Ricovero e Cura a Carattere Scientifico
2016
Vita-Salute San Raffaele University
2011-2013
Transcranial direct current stimulation is emerging as a promising tool for the treatment of several neurological conditions, including cerebral ischemia. The therapeutic role this noninvasive is, however, limited to chronic phases stroke. We thus ought investigate whether different protocols could also be beneficial in acute phase experimental brain ischemia.The influence both cathodal and anodal transcranial modifying metabolism healthy mice was first tested by nuclear magnetic resonance...
Shortly after the application of weak transcranial direct current stimulation (tDCS) to animal and human brain, changes in corticospinal excitability, which mainly depend on polarity, duration density protocol, have been reported. In humans, anodal tDCS has reported enhance motor-evoked potentials (MEPs) elicited by brain while cathodal shown decrease them. Here we investigated effects produced mice motor cortex. MEPs evoked electric were recorded from forelimbs 12 C57BL/6 mice, under...
Negative experiences are quickly learned and long remembered. Key unresolved issues in the field of emotional memory include identifying loci dynamics storage retrieval. The present study examined neural activity higher-order auditory cortex Te2 basolateral amygdala (BLA) their crosstalk during recall recent remote fear memories. To this end, we obtained local potentials multiunit recordings BLA rats that underwent at 24 h 30 d after association an acoustic conditioned (CS, tone) aversive...
The functional significance of adult neural stem and progenitor cells in hippocampal-dependent learning memory has been well documented. Although the subventricular zone are known to migrate to, maintain reorganize olfactory bulb, it is less clear whether they functionally required for other processes. Using a conditional transgenic mouse model, selective ablation induced dramatic increase morbidity mortality central nervous system disorders characterized by excitotoxicity-induced cell death...
Summary Tuberous sclerosis complex (TSC) is a dominantly inherited disease with high penetrance and morbidity, caused by mutations in either of two genes, TSC1 or TSC2. Most affected individuals display severe neurological manifestations – such as intractable epilepsy, mental retardation autism that are intimately associated peculiar CNS lesions known cortical tubers (CTs). The existence significant genotype-phenotype correlation bearing TSC2 highly controversial. Similar to observations...
Abstract The sensory cortex participates in emotional memory but its role is poorly understood. Here we show that inactivation of the higher order auditory Te2 rats during early consolidation impairs remote first- and second-order fear memories not association between two neutral cues. Furthermore, prevents changes valence such information. Following presentation cues previously paired with either pleasant or painful stimuli, a large percentage cells responds to both experiences also small...
The medial prefrontal cortex and the basolateral amygdala (BLA) are essential for discriminating between harmful safe stimuli. primary auditory (Te1) sends projections to both sites, but whether how it interacts with these areas during fear discrimination poorly understood. Here we show that in male rats can differentiate a new tone threatening one, selective optogenetic inhibition of Te1 axon terminals into prelimbic (PL) shifted generalization. Meanwhile, no effects were detected when...
Low-frequency repetitive transcranial magnetic stimulation (1-Hz rTMS) is a promising noninvasive tool for the treatment of depression. Hippocampal neuronal plasticity thought to play pivotal role in pathophysiology depressive disorders and mechanism action antidepressant treatments. We investigated effect 1-Hz rTMS on hippocampal dentate gyrus structural related emotional behaviors modifications. Experimentally, adult male mice received either five days or Sham stimulation. After...
The synthesis of melatonin (MLT) physiologically decreases during aging. Treatment with MLT has shown anxiolytic, hypnotic, and analgesic effects, but little is known about possible age-dependent differences in its efficacy. Therefore, we studied the effects (20 mg/kg, intraperitoneal) on anxiety-like behavior (open field (OFT), elevated plus maze (EPMT), three-chamber sociability, marble-burying (MBT) tests), medial prefrontal cortex (mPFC)-dorsal hippocampus (dHippo) circuit adolescent...
Up to approximately 70% of cancer survivors report persistent deficits in memory, attention, speed information processing, multi-tasking, and mental health functioning, a series symptoms known as "brain fog." The severity duration such effects can vary depending on age, type, treatment regimens. In particular, every year, hundreds thousands patients worldwide undergo radiotherapy (RT) for primary brain tumors metastases originating from extracranial tumors. Besides its potential benefits the...
Rac GTPases regulate the development of cortical/hippocampal GABAergic interneurons by affecting early and migration precursors. We have addressed function Rac1 Rac3 proteins during late maturation hippocampal interneurons. observed specific phenotypic differences between conditional full knockout mice. deletion caused greater generalized hyperactivity cognitive impairment compared with deletion. This phenotype matched a more evident functional inhibitory circuits in mutants, showing higher...
Abstract Cognitive processing is highly dependent on the functional integrity of gamma-amino-butyric acid (GABA) interneurons in brain. These cells regulate excitability and synaptic plasticity principal neurons balancing excitatory/inhibitory tone cortical networks. Reduced function parvalbumin (PV) disruption GABAergic synapses circuitry result desynchronized network activity associated with cognitive impairment across many psychiatric disorders, including schizophrenia. However,...
Early stroke therapeutic approaches rely on limited options, further characterized by a narrow time window. In this context, the application of transcranial direct current stimulation (tDCS) in acute phases after brain ischemia is emerging as promising non-invasive tool. Despite wide clinical tDCS, cellular mechanisms underlying its positive effects are still poorly understood. Here, we explored cathodal tDCS (C-tDCS) 6 h focal forelimb M1 Cx3CR1GFP/+ mice. C-tDCS improved motor...
Treating neurologic disorders with noninvasive brain stimulation techniques has always been one of the major goals neurophysiology and to a broad extent, modern neurology psychiatry. The first attempts date back at least 50 ad, when Roman physician Scribonius Largus used electric currents from torpedo fishes treat headaches.1 Unfortunately, these initial efforts sank into oblivion until 18th century. In last 2 decades, thanks technological improvements, transcranial is re-emerging as an...
The auditory cortex is involved in encoding sounds which have acquired an emotional–motivational charge. However, the neural circuitry engaged by emotional memory processes poorly understood. In this study, we investigated layers and regions that are recruited higher order Te2 a tone previously paired to either fear or appetitive stimuli rats. By tracking protein coded immediate early gene zif268, found retrieval engages II–III most of Te2. These results were neither due enhanced state nor...
Memories of frightening events require a protracted consolidation process. Sensory cortex, such as the auditory is involved in formation fearful memories with more complex sensory stimulus pattern. It remains controversial, however, whether cortex also required for related to simple stimuli. In present study, we found that, 1 d after training, temporary inactivation either most anterior region including primary (Te1) or posterior region, which included secondary (Te2) component, did not...