A5102902283- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Protein Kinase Regulation and GTPase Signaling
- Neuropeptides and Animal Physiology
- Ion channel regulation and function
- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- Nerve injury and regeneration
- Bipolar Disorder and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Aldose Reductase and Taurine
- Lipid metabolism and disorders
- Nuclear Receptors and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine regulation and behavior
- Pain Mechanisms and Treatments
- Treatment of Major Depression
- Cholinesterase and Neurodegenerative Diseases
- Pharmacological Receptor Mechanisms and Effects
- Protein Tyrosine Phosphatases
- Nitric Oxide and Endothelin Effects
- Adenosine and Purinergic Signaling
- Anesthesia and Neurotoxicity Research
- CNS Lymphoma Diagnosis and Treatment
New York Medical College
2002-2021
City University of New York
2010-2021
City College of New York
2010-2021
The Graduate Center, CUNY
2011-2020
CUNY School of Law
2002-2020
University of Miami
2013-2017
National Institutes of Health
2016
Center for Cancer Research
2016
National Cancer Institute
2016
Jackson Memorial Hospital
2013
Repetitive transcranial magnetic stimulation (rTMS) induces neuronal long-term potentiation or depression. Although brain-derived neurotrophic factor (BDNF) and its cognate tyrosine receptor kinase B (TrkB) contribute to the effects of rTMS, their precise role underlying mechanism remain poorly understood. Here we show that daily 5 Hz rTMS for d improves BDNF–TrkB signaling in rats by increasing affinity BDNF TrkB, which results higher tyrosine-phosphorylated increased recruitment PLC-γ1...
Abstract: Dopamine and the D 1 , receptor agonist SKF 38393 activate phospholipase C‐rnediated hydrolysis of phosphoinositides in brain slices. This action is selectively inhibited by SCH‐23390, thus suggesting its mediation through dopamine receptor. To determine if that mediates Phosphoinositide adenylyl, cyclase‐linked or a different subtype receptor, 20 benzazepine compounds were previously characterized as selective agonists tested for stimulation rat striatal slices activation adenylyl...
// Rika Fujii 1 , Eitan R. Friedman Jacob Richards Kwong Y. Tsang Christopher Heery Jeffrey Schlom and James W. Hodge Laboratory of Tumor Immunology Biology, Center for Cancer Research, National Institute, Institutes Health, Bethesda, MD, USA Correspondence to: Hodge, email: Keywords : chordoma, programmed death-ligand (PD-L1), antibody-dependent cell-mediated cytotoxicity (ADCC), cancer stem cells, immunotherapy Received March 21, 2016 Accepted April 26, Published May 09, Abstract Chordoma,...
Abstract Previously a distinct D 1 ‐like dopamine receptor (DAR) that selectively couples to phospholipase C/phosphatidylinositol (PLC/PI) was proposed. However, lack of selective agonist has limited efforts aimed at characterizing this receptor. We characterized the in vitro and vivo effects SKF83959 regulating PI metabolism. stimulates (EC 50 , 8 µm) phosphatidylinositol 4,5‐biphosphate hydrolysis membranes frontal cortex (FC) but not from PC12 cells expressing classical 1A DARs....
Kaposi's sarcoma (KS) is an enigmatic vascular tumor thought to be a consequence of dysregulated expression the human herpesvirus-8 (HHV-8 or KSHV)-encoded G protein-coupled receptor (vGPCR). Indeed, transgenic animals expressing vGPCR manifest tumors histologically identical KS, with viral limited few cells, suggestive paracrine mechanism for tumorigenesis. Both and experimental KS lesions are characterized by prominent angiogenesis permeability attributed release angiogenic molecules, most...
Kaposi's sarcoma (KS) is a vascular neoplasm characterized by the dysregulated expression of angiogenic and inflammatory cytokines. The driving force KS lesion, KSHV-infected spindle cell, secretes elevated levels endothelial growth factor (VEGF), essential for development. However, origin VEGF in this tumor remains unclear.Here we report that KSHV G protein-coupled receptor (vGPCR) upregulates through an intricate paracrine mechanism. cytokines secreted few vGPCR-expressing cells activate...
Mitogen-activated protein kinases (MAPKs) play important roles in cell proliferation, differentiation, and apoptosis. Important functional for MAPKs postmitotic cells have recently been suggested. In the present study, we investigated effect of aging on brain ERK (extracellular signal-regulated kinase) p38 MAPK signaling pathways Fischer 344 rats. The results show that basal tyrosine-phosphorylated ERK1/ERK2 cortex 24-month-old rats was reduced by 36%–59%, compared to 6- 12-month-old (p <...
We investigated the effects of D<sub>1</sub> dopamine receptor stimulation on activation mitogen-activated protein kinases (MAPKs) in SK-N-MC human neuroblastoma cells. found that agonist SKF38393 induced similar time- and dose-related p38 MAPK c-Jun amino-terminal kinase (JNK), whereas extracellular signal-regulated activity was not affected by stimulation. Maximal JNK observed after a 15-min incubation with 100 μm SKF38393. In contrast, 10 μmquinpirole, D<sub>2</sub> agonist, did activate...
Abstract— A series of serotonin and phenethylamine analogs were tested for their ability to differentially inhibit type or B monoamine oxidase (EC 1.4.3.4) in rat hypothalamus. The most specific potent effects shown by several tetrahydro‐β‐carbolines which competitively inhibited the oxidative deamination at micromolar concentrations. In contrast, effective inhibition was observed only near millimolar concentrations these drugs. Significant reductions but not MA0 activity also after...
Application of orthosteric sigma-1 receptor agonists as anti-seizure drugs has been hindered by questionable efficacy and potential adverse effects. Here, we have investigated the effects novel potent allosteric modulator receptors, SKF83959 its derivative SOMCL-668 (3-methyl-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol).
The serotonin-1A (5-HT1A) receptor is a key regulator of serotonergic activity and implicated in mood emotion. However, its post-transcriptional regulation has never been studied humans. In the present study, we show that "intronless" human 5-HT1A gene (HTR1A) alternatively spliced 3'-UTR, yielding two novel splice variants. These variants lack ∼1.6 kb intron, which contains an microRNA-135 (miR135) target site. Unlike HTR1A, mouse HTR1A lacks donor/accepter sites. Thus, splicing was not...