A5005366049- Neuroscience and Neuropharmacology Research
- Mesenchymal stem cell research
- Anesthesia and Neurotoxicity Research
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Bone Tissue Engineering Materials
- Biochemical effects in animals
- Cannabis and Cannabinoid Research
- Cardiac Ischemia and Reperfusion
- Tissue Engineering and Regenerative Medicine
- Neurological Disease Mechanisms and Treatments
- Reproductive Biology and Fertility
- Electrospun Nanofibers in Biomedical Applications
- Adenosine and Purinergic Signaling
- Periodontal Regeneration and Treatments
- Ovarian function and disorders
- Epilepsy research and treatment
- Sperm and Testicular Function
- Stress Responses and Cortisol
- Forensic Toxicology and Drug Analysis
- Graphene and Nanomaterials Applications
- Coenzyme Q10 studies and effects
- Adipose Tissue and Metabolism
- Fatty Acid Research and Health
Iran University of Medical Sciences
2015-2024
Shahid Beheshti University of Medical Sciences
2021
Islamic Azad University, Malayer Branch
2021
Case Western Reserve University
2016
Cornell University
2016
University of Leeds
2016
Alborz University of Medical Sciences
2015
Jahrom University of Medical Sciences
2015
Sarem Cell Research Center
2015
Tehran University of Medical Sciences
2011-2014
Abstract Bone regeneration is considered as an unmet clinical need, the aim of this study to investigate osteogenic potential three different mesenchymal stem cells (MSCs) derived from human bone marrow (BM‐MSCs), umbilical cord Wharton's jelly (UC‐MSCs), and adipose (AD‐MSCs) seeded on a recently developed nanocomposite scaffold (bioactive glass/gelatin) implanted in rat animal models with critical size calvarial defects. In study, after isolation, culture, characterization, MSCs were...
Abstract Bone marrow-derived mesenchymal stem cells (BM-MSCs) play a role in wound healing and tissue repair may also be useful for organ regeneration. As we have demonstrated previously that A2A adenosine receptors (A2AR) promote by stimulating local mechanisms enhancing accumulation of endothelial progenitor cells, investigated whether A2AR activation modulates BM-MSC proliferation differentiation. BM-MSCs were isolated cultured from A2A-deficient ecto-5′nucleotidase (CD73)-deficient...
Oxidative stress is one of the pathological mechanisms responsible for beta‐ amyloid cascade associated with Alzheimer’s disease (AD). Previous studies have demonstrated role carnosic acid (CA), an effective antioxidant, in combating oxidative stress. A progressive cognitive decline hallmarks AD. Thus, we attempted to determine whether administration CA protects against memory deficit caused by beta‐amyloid toxicity rats. Beta‐amyloid (1–40) was injected stereotaxic surgery into Ca1 region...
Abstract Metabolic diabetes mellitus as the most serious and prevalent metabolic disease in world has various complications. The effective treatment of type I seems to be islet cell transplantation. Shortage donors difficult procedures high rate rejection have always restricted this approach. Tissue engineering is a novel solution many medical problems such diabetes. Endometrial mesenchymal stem cells lineage which potential differentiate mesodermal endodermal tissues seem suitable for...
The present study used a previously developed three-dimensional Gelatin/Hydroxyapatite (Gel/HA) homogeneous nanocomposite scaffold with porosity of 82% and interconnecting pores ranging from 300 to 500 μm. Cell-seeded scaffolds were evaluate bone regeneration rat critical-size calvarial defect. Totally, 36 male Wistar rats randomly divided into four experimental groups, including blank defect (defects without any graft), filled Gel/HA cells), two groups cell-seeded either seeded...
Apoptosis, as well necrosis, has an important role in post-ischemic renal pathology. The effect of pretreatment with Docosahexaenoic acid+Eicosapentaenoic acid (DHA+EPA) on injury and apoptotic protein expression was evaluated. Right nephrectomy completed male Wistar rats (255-300 g). received DHA+EPA (200 mg/kg/day) distilled water orally for 14 days before ischemia reperfusion (IR) or sham operation. A total 81 were divided into three main groups 6, 24 48 h post-operation period. Serum...
Oleuropein is a phenolic compound which present in the olive leaf extract. The purpose of study was to investigate neuroprotective effect oleuropein as an antioxidant agent on substantia nigra aged rats.Twenty 18-month-old Wistar rats (450-550 g) were randomly divided into control and experimental groups. group received daily single dose 50 mg/kg by oral gavage for 6 months. only distilled water. All sacrificed two hours after last brains removed midbrains cut. One part homogenized...
Ovarian tissue cryopreservation together with follicle culture provides a promising technique for fertility preservation in cancer patients. The study aimed to evaluate parameters medium supplemented VEGFA165 and/or fetuin. Vitrified-warmed ovarian cortical pieces were divided randomly into four groups consisting of basic (control), and the VEGFA165, fetuin or both. After six days culture, we evaluated following: percentage resting, primary secondary growing follicles; survival rate; steroid...
Implantation of a suitable nerve guide conduit (NGC) seeded with sufficient Schwann cells (SCs) is required to improve peripheral regeneration efficiently. Given the limitations isolating and culturing SCs, using various sources stem cells, including mesenchymal (MSCs) obtained from nasal olfactory mucosa, can be desirable. Olfactory ecto-MSCs (OE-MSCs) are new population neural crest-derived that proliferate differentiate into SCs considered promising autologous alternative produce SCs....
Mitochondrial ATP-sensitive potassium channel opener, diazoxide, is shown to have protective effect on the heart and brain following ischemia-reperfusion-induced injury (IR/II). However, detailed of diazoxide its antagonist neuronal death, mitochondrial changes, apoptosis in cerebral IR/II has not fully studied. was induced rats by 4-vessel occlusion model. Neuronal cell death changes CA1–CA4 pyramidal cells hippocampus were studied light electron microscopy, respectively. Apoptosis assessed...
Excitatory GABA actions, induced by altered expression of chloride transporters (KCC2/NKCC1), can contribute to seizure generation in temporal lobe epilepsy. In the present study, we evaluated whether BDNF administration affect KCC2/NKCC1 expression, ictogenesis and behavioral alterations this paradigm. Status epilepticus was male rats with pilocarpine, followed a treatment either single high dose or multiple injections during latent phase Chloride spontaneous recurrent seizures,...