A5054306438- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Intensive Care Unit Cognitive Disorders
- Pediatric health and respiratory diseases
- Asthma and respiratory diseases
- Smoking Behavior and Cessation
- School Health and Nursing Education
- Tuberculosis Research and Epidemiology
- Airway Management and Intubation Techniques
- Sepsis Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- MicroRNA in disease regulation
- Nosocomial Infections in ICU
- Neuroscience of respiration and sleep
- Tracheal and airway disorders
- Air Quality and Health Impacts
- Antibiotic Use and Resistance
- Cardiac Arrest and Resuscitation
- Respiratory and Cough-Related Research
- Extracellular vesicles in disease
- Lung Cancer Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Masih Daneshvari Hospital
2016-2025
Shahid Beheshti University of Medical Sciences
2016-2025
Shahid Beheshti University
2011-2023
Weatherford College
2020
Iranian Orthopedic Association
2019
Mazandaran University of Medical Sciences
2019
Oregon Health & Science University
2019
Baqiyatallah University of Medical Sciences
2014-2019
Shenzhen Chronic Disease Prevention Center
2015
Tobacco Research Institute
2013
To validate a questionnaire to assess stress and burnout in healthcare workers during COVID-19 pandemic.In this study, content validity, Cronbach's alpha, test-retest reliability method were utilized among 60 HCWs evaluate the internal consistency, of respectively. The final was composed four parts asking for background information, questions about caused by COVID-19, Depression, Anxiety Stress Scale - 21 (DASS-21), six from Copenhagen Burnout Inventory (CBI).The CVR 46 equal 1, making them...
Acute respiratory distress syndrome (ARDS) is a fatal complication of coronavirus disease 2019 (COVID-19). There are few reports allogeneic human mesenchymal stem cells (MSCs) as potential treatment for ARDS. In this phase 1 clinical trial, we present the safety, feasibility, and tolerability multiple infusions high dose MSCs, which originated from placenta umbilical cord, in critically ill COVID-19-induced ARDS patients.A total 11 patients diagnosed with who were admitted to intensive care...
The main causes of death in patients with severe Coronavirus disease-2019 (COVID-19) are acute respiratory distress syndrome (ARDS) and multiorgan failure caused by a inflammatory cascade. Novel treatment strategies, such as stem-cell-based therapy their derivatives can be used to relieve inflammation these cases. In this study, we aimed evaluate the safety efficacy using mesenchymal stromal cells (MSCs) derived extracellular vesicles COVID-19 patients.
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes disease 2019 (COVID-19) has infected over 112M patients and resulted in almost 2.5M deaths worldwide. The major clinical feature of severe COVID-19 requiring ventilation is distress (ARDS) possibly associated with a cytokine storm. Objectives To elucidate serum levels TNF-α soluble TNF-Receptor 1 (sTNFR1) mild as determinants severity. Methods We determined sTNFR1 concentrations 46 laboratory-confirmed (17...
Background Chronic obstructive pulmonary disease (COPD) is a major global health problem with cigarette smoke (CS) as the main risk factor for its development. Airway inflammation in COPD involves increased expression of inflammatory mediators such CXCL-8 and IL-1β which are important neutrophil recruitment. Macrophages an source these COPD. Lactobacillus rhamnosus (L. rhamnosus) Befidobacterium breve (B. breve) attenuate development ‘allergic asthma’ animals but their effects unknown....
Abstract Anxiety is prevalent in asthma, and associated with disease severity poor quality of life. However, no study to date provides direct experimental evidence for the effect allergic inflammation on structure function medial prefrontal cortex (mPFC) amygdala, which are essential regions modulating anxiety its behavioral expression. We assessed impact ovalbumin (OVA)-induced appearance anxiety-like behavior, mPFC amygdala volumes using MRI, mPFC-amygdala circuit activity sensitized rats....
A number of cardiopulmonary resuscitation (CPR) adjunct devices have been developed to improve the consistency and quality manual chest compressions. We investigated whether a CPR feedback device would consistency, as well patient survival. conducted randomized controlled study patients undergoing for cardiac arrest in mixed medical-surgical intensive care units four academic teaching hospitals. Patients were receive either standard or using Cardio First Angel™ device. Recorded variables...
Cytokine release syndrome is prevalent in severe cases of COVID-19. In this syndrome, an uncontrolled response immune system occurs. Extracorporeal blood purification has been proven to effectively remove the released inflammatory cytokines. Here, we reported a successful case represent our experience extracorporeal patient with
In December 2019, pneumonia associated with a novel coronavirus (COVID-19) was reported in Wuhan, China. Acute respiratory distress syndrome (ARDS) is the most frequently observed complication COVID-19 patients high mortality rates. To observe clinical effect of plasmapheresis on excessive inflammatory reaction and immune features severe at risk ARDS. this single-center study, we included 15 confirmed cases Masih Daneshvari Hospital, March 2020 Tehran, Iran. were by RT-PCR CT imaging...
COVID-19 is currently causing concern in the medical community as virus spreading around world. It has a heavy global burden, particularly low-income countries. The clinical spectrum of pneumonia ranges from mild to critically ill cases and Acute Respiratory Distress Syndrome. An expert panel was held an internal protocol developed manage induced ARDS according WHO recommendations NIH guidelines. Different therapeutic regimens were employed on this based severity patients' special...
Bromhexine is a potent inhibitor of transmembrane serine protease 2 and appears to have an antiviral effect in controlling influenza parainfluenza infection; however, its efficacy COVID-19 controversial.A group hospitalized patients with confirmed pneumonia were randomized using 1:1 allocation either standard treatment lopinavir/ritonavir interferon beta-1a or bromhexine 8 mg four times day addition therapy. The primary outcome was clinical improvement within 28 days, the secondary measures...
The cardinal features of asthma include airway inflammation, hyper responsiveness (AHR) and remodeling. Exosomes help orchestrate the immune response contain microRNAs (miRNAs) such as miRNA-155 miRNA-221 which play significant roles in pathogenesis exacerbations severe asthma. In this study, we aimed to investigate exosomal expression miRNAs (155, 221) serum patients. Eighteen moderate-to-severe patients eighteen healthy subjects were recruited for study. Serum exosomes isolated...
ABSTRACT Background and Aims Critically ill patients in COVID‐19 to the intensive care unit (ICU) may develop multiple organ dysfunction syndrome, with some requiring extracorporeal support. This study aimed assess effects of combined CytoSorb hemoperfusion (HP) continuous renal replacement therapy (CRRT) on improvement multiorgan failure COVID‐19. Methods Fifty‐six hospitalized ICU a confirmed diagnosis were included this quasi‐experimental study. All had acute respiratory distress syndrome...