A5020207050- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Renal and related cancers
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Research on Leishmaniasis Studies
- Tissue Engineering and Regenerative Medicine
- Viral-associated cancers and disorders
- RNA modifications and cancer
- Glioma Diagnosis and Treatment
- 3D Printing in Biomedical Research
- Pluripotent Stem Cells Research
- Electrospun Nanofibers in Biomedical Applications
- Prenatal Screening and Diagnostics
- Renal cell carcinoma treatment
- Cancer Cells and Metastasis
- Neonatal Respiratory Health Research
- Hematopoietic Stem Cell Transplantation
- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Genomic variations and chromosomal abnormalities
- CAR-T cell therapy research
- Thyroid Cancer Diagnosis and Treatment
- Scheduling and Optimization Algorithms
- Bone Tissue Engineering Materials
Shariati Hospital
2016-2025
Tehran University of Medical Sciences
2016-2025
Massachusetts General Hospital
2024
Boston University
2024
Children's Medical Center
2017-2023
University of Tehran
2004-2022
Iran University of Medical Sciences
2019
Tarbiat Modares University
2012
Shiraz University of Medical Sciences
2001-2011
Shahid Chamran University of Ahvaz
2011
Epithelial cell adhesion molecule (Ep-CAM; CD326) is used as a target by many immunotherapeutic approaches, but little data are available about Ep-CAM expression in major human malignancies with respect to level, frequency, tumour stage, grade, histologic type and impact on survival. We analysed immunohistochemical staining tissue microarrays 4046 primary carcinoma samples from colon, stomach, prostate lung cancers for both frequency intensity of under highly standardised conditions. A total...
Acute respiratory distress syndrome (ARDS) is a fatal complication of coronavirus disease 2019 (COVID-19). There are few reports allogeneic human mesenchymal stem cells (MSCs) as potential treatment for ARDS. In this phase 1 clinical trial, we present the safety, feasibility, and tolerability multiple infusions high dose MSCs, which originated from placenta umbilical cord, in critically ill COVID-19-induced ARDS patients.A total 11 patients diagnosed with who were admitted to intensive care...
The possible immunomodulatory role of polymorphonuclear leukocytes (PMN) in CD4+ T lymphocyte differentiation mice was examined by studying the effect transient depletion PMN during early phase after Leishmania major delivery. A single injection PMN-depleting NIMP-R14 mAb 6 h before infection with L. prevented burst IL-4 mRNA transcription otherwise occurring draining lymph node susceptible BALB/c mice. Since this transcripts had previously been shown to instruct Th2 from strain, we on Th...
Long noncoding RNAs (lncRNAs) have emerged as new regulators of stem cell pluripotency and tumorigenesis. The SOX2 gene, a master regulator pluripotency, is embedded within the third intron lncRNA known overlapping transcript (SOX2OT). SOX2OT has been suspected to participate in regulation expression and/or other related processes; nevertheless, its potential involvement tumor initiation progression unclear. Here, we evaluated possible correlation between patterns those OCT4, esophageal...
MicroRNAs (miRNAs) play a key role in tumor metastasis based on their capacity to regulate the expression of tumor-related genes. Over-expression genes such as c-MYC and CTNNB1 (encoding β-catenin) Wnt/β-catenin-dependent ROCK1 Wnt/β-catenin-independent signaling pathways (Rho/Rho-associated kinase (ROCK) pathway) has already been identified hallmarks many tumors, breast cancer also investigated confirmed. miR-340 characterization an onco-suppressor miRNA previously reported. However,...
Objective MiR-21 is an oncomir expressed by malignant cells and/or tumor microenvironment components. In this study we focused on understanding the effects of stromal miR-21 esophageal cells. Design expression was evaluated in formalin-fixed paraffin-embedded samples from patients with squamous-cell carcinoma (SCC) quantitative RT-PCR. tissue distribution visualized situ hybridization. A co-culture system normal fibroblasts and cancer used to determine levels, SCC cell migration invasion....
Visceral leishmaniasis (VL) is a vector-borne disease affecting humans and domestic animals that constitutes serious public health problem in many countries. Although antigens have been examined so far as protein- or DNA-based vaccines, none of them conferred complete long-term protection. The use the lizard non-pathogenic to Leishmania (L.) tarentolae species live vaccine vector deliver specific recent approach needs be explored further. In this study, we evaluated effectiveness vaccination...
In this study, thick polyethersulfone (PES) nanofibrous scaffolds were prepared by fine tuning of electrospinning parameters and was evaluated for wound dressing applications.Scanning electron microscopy Brunauer-Emmett-Teller methods used PES nanofibers characterization. The interaction between fibroblasts studied in vitro. Further, a mouse model to evaluate the effectiveness scaffold healing. Vaseline gauze conventional gas permeable bandage as control. repair process histological...
MicroRNAs (miRNAs) are a major class of small endogenous RNA molecules that posttranscriptionally regulate the expression most genes in human genome. miRNAs often located chromosomal fragile sites, which suscept-ible to amplification or deletion. Chromosomal deletions frequent events breast cancer cells. Deletion and loss heterozygosity at 17p13.3 have been reported 49% cancers. The aim current study was evaluate potential alterations miR-22, miR-132, miR-212, on locus required for mammary...
ABSTRACT A critical clinical consideration, in addition to other common risk factors predisposing individuals idiopathic intracranial hypertension (IIH), involves the potential co‐occurrence of increased pressure and elevated cerebrospinal fluid protein levels presence underlying malignancies. Primary diffuse leptomeningeal melanomatosis, an exceptionally rare condition with few reported cases pediatric population, illustrates this scenario. Timely decision‐making based on suspicion perform...
Objective: This study aimed to assess the safety and efficacy of tissue Plasminogen Activator (tPA) in patients with COVID-19-induced severe Acute Respiratory Distress Syndrome (ARDS). Methods: The intervention group consisted eligible ARDS due COVID-19 admitted Intensive Care Unit (ICU) a university hospital. We selected control from treated same ICU within period. received intravenous tPA as 10 mg stat, 40 over first 2 hours, 25-50 next followed by therapeutic dose enoxaparin. only main...
Perivascular epithelioid cell tumors (PEComas) of the kidney are rare mesenchymal that rarely occur in children. Individuals with tuberous sclerosis (TS) at increased risk for these tumors. While classic PEComas benign, variant could have malignant potential and metastasis capacity. We report a case right PEComa uncertain 3-year-old girl who had no personal or family history sclerosis. The tumor was found through ultrasound imaging. Sections from radical nephrectomy specimen showed spindle...
<i>Background:</i> Cutaneous leishmaniasis (CL) is a major problem in many tropical and subtropical countries. The clinical diagnosis should be confirmed by identification of the parasite biopsy or smear tissue culture. sensitivity direct microscopy not high, culture uniformly available successful. Polymerase chain reaction (PCR) sensitive test for detection low amounts DNA tissues. <i>Objective:</i> We applied PCR on paraffin-embedded skin biopsies to assess validity...
The therapeutic potential of bone marrow mesenchymal stem cells (MSCs) in kidney failure has been examined some studies. However, recent findings indicate that after transplantation, these home to kidneys at very low levels. Interaction stromal derived factor-1 (SDF-1) with its receptor, CXCR4, is pivotal importance migration and homing. Recently, CXCR7 also recognized as another SDF-1 receptor interacts CXCR4 modulates functions. In this study, were separately simultaneously overexpressed...
The use of an appropriate delivery system has recently emerged as a promising approach for the development effective vaccination against visceral leishmaniasis (VL). Here, we compare two vaccine systems, namely electroporation and cationic solid-lipid nanoparticle (cSLN) formulation, to administer DNA harbouring L. donovani A2 antigen along with infantum cysteine proteinases [CPA CPB without its unusual C-terminal extension (CPB(-CTE) )] evaluate their potential challenge. Prime-boost...
BACKGROUND: miRNAs have recently been implicated in tumor's microenvironment remodeling and tumor-stromal cells interactions. We previously reported a signaling role for miR-21, as secretory molecule released by cancer associated fibroblasts (CAF) adjacent to esophagus tumor cells. OBJECTIVE : To discover other potential miRNAs, we employed co-culture system of esophageal cell line normal mimic the microenvironment. METHODS: measured expression profile conditioned media (CM) our using panel...
Breast cancer is a heterogeneous disease, and among all types, triple-negative breast (TNBC) characterised by high risk of recurrence. The discovery microRNAs (miRNA) has opened the door for targeted therapy TNBC. miR-340 down-regulation sub-G1-accumulated cells in flowcytometry were observed metastatic TNBC (data publication), leading us to investigate potential tumour suppressive role this miRNA on cell-cycle-related genes. A lentiviral vector containing was applied over-express cell line,...
Aim Wilms tumor (WT) usually shows a bi-phasic or tri-phasic morphology comprised of blastemal, stromal, and epithelial cells. Other biphasic renal tumors that can mimic WT may pose diagnostic dilemmas especially in preoperative needle biopsy samples. This tissue microarray study was designed to investigate the immunohistochemical features prove useful accurate diagnosis small Methods Eight punches from each paraffin block 45 cases WTs were used construct 5 blocks. Immunohistochemical...