A5040301840- Sarcoidosis and Beryllium Toxicity Research
- COVID-19 Clinical Research Studies
- COVID-19 diagnosis using AI
- Chronic Obstructive Pulmonary Disease (COPD) Research
- SARS-CoV-2 and COVID-19 Research
- Respiratory Support and Mechanisms
- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Long-Term Effects of COVID-19
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tuberculosis Research and Epidemiology
- Asthma and respiratory diseases
- Medical Imaging and Pathology Studies
- Infectious Diseases and Tuberculosis
- COVID-19 epidemiological studies
- Pleural and Pulmonary Diseases
- Respiratory and Cough-Related Research
- Ultrasound in Clinical Applications
- Reproductive Biology and Fertility
- Congenital Diaphragmatic Hernia Studies
- Pulmonary Hypertension Research and Treatments
- Digital Imaging for Blood Diseases
- Heparin-Induced Thrombocytopenia and Thrombosis
- Drug-Induced Adverse Reactions
- COVID-19 Pandemic Impacts
Shahid Beheshti University of Medical Sciences
2016-2025
Masih Daneshvari Hospital
2016-2025
Shahid Beheshti University
2021-2025
Université de Montréal
2024
Ottawa Hospital Research Institute
2017-2023
Ottawa Hospital
2017-2023
University of Ottawa
2017-2022
ORCID
2021
Weatherford College
2020
Kerman University of Medical Sciences
2015
Abstract Inactivating mutations in SMARCA4 ( BRG1 ), a key SWI/SNF chromatin remodelling gene, underlie small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). To reveal its druggable vulnerabilities, we perform kinase-focused RNAi screens and uncover that SMARCA4-deficient SCCOHT cells are highly sensitive to inhibition cyclin-dependent kinase 4/6 (CDK4/6). loss causes profound downregulation cyclin D1, which limits CDK4/6 activity leads vitro vivo susceptibility inhibitors. patient...
Early prediction of patient mortality risks during a pandemic can decrease by assuring efficient resource allocation and treatment planning. This study aimed to develop compare prognosis machine learning models based on invasive laboratory noninvasive clinical demographic data from patients’ day admission. Three Support Vector Machine (SVM) were developed compared using invasive, non-invasive, both groups. The results suggested that non-invasive features could provide predictions are similar...
The development of medical assisting tools based on artificial intelligence advances is essential in the global fight against COVID-19 outbreak and future systems. In this study, we introduce ai-corona , a radiologist-assistant deep learning framework for infection diagnosis using chest CT scans. Our incorporates an EfficientNetB3-based feature extractor. We employed three datasets; CC-CCII set, MasihDaneshvari Hospital (MDH) cohort, MosMedData cohort. Overall, these datasets constitute 7184...
Abstract Background High morbidity and mortality rates of the COVID-19 pandemic have made it a global health priority. Acute respiratory distress syndrome (ARDS) is one most important causes death in patients. Mesenchymal stem cells been subject many clinical trials for treatment ARDS because their immunomodulatory, anti-inflammatory, regenerative potentials. The aim this phase I trial was safety assessment allogeneic placenta-derived mesenchymal (PL-MSCs) intravenous injection patients with...
Background: The epidemiology of facial injuries varies in different countries and geographic zones.Population concentration, lifestyle, cultural background, socioeconomic status can affect the prevalence maxillofacial injuries.Therefore, this study, we evaluated fractures treatment plans hospitalized patients (2012-2014) which would be useful for better policy making strategies.Material Methods: In retrospective medical records 386 were from department surgery at Bahonar Hospital Kerman,...
Cytokine release syndrome is prevalent in severe cases of COVID-19. In this syndrome, an uncontrolled response immune system occurs. Extracorporeal blood purification has been proven to effectively remove the released inflammatory cytokines. Here, we reported a successful case represent our experience extracorporeal patient with
Polycystic ovarian syndrome (PCOS) is associated with hyperandrogenemia and antral follicle growth arrest. We have previously demonstrated that androgen-induced exosomal release of miR-379-5p (miR379) from preantral granulosa cells increases the proliferation target via phosphoinositide-dependent kinase 1 (PDK1) upregulation. Androgen also inflammatory M1 macrophage abundance, but reduces anti-inflammatory M2 polarization in rat preovulatory follicles. However, role small extracellular...
This study aims to compare Lung Ultrasound (LUS) findings with High-Resolution Computerized Tomography (HRCT) and Pulmonary Function Tests (PFTs) detect the severity of lung involvement in patients Usual Interstitial Pneumonia (UIP) Non-Specific (NSIP). A cross-sectional was conducted on 35 UIP 30 NSIP at a referral hospital. All underwent LUS, HRCT, PFT. LUS such as B-lines, pleural fragmentation, thickening were compared HRCT-based PFT parameters. In patients, B-lines > 18 fragmentation...
Introduction The global coronavirus disease 2019 (COVID-19) pandemic necessitated urgent vaccine development, raising concerns about potential adverse events (AEs). Methods In this prospective cohort study, conducted from February 2021 to December 2022, all individuals across Iran who received any COVID-19 dose and reported were investigated. Our aim was evaluate these AEs based on the types, patients’ age types of AES, provide a comprehensive analysis. Results Iran, 155 million doses...
Background:Sarcoidosis is an inflammatory disease that affects multiple organs.Before widespread use of computed tomography (CT), the severity sarcoidosis was assessed based on chest X-ray abnormalities.HRCT can distinguish between active changes and irreversible fibrosis.In this study, we analyzed different ACE levels in 148 patients diagnosed with sarcoidosis. Material/Methods:We categorized these their HRCT results into four groups: 1) chronic disease; 2) non-chronic 3) who exhibited...
Introduction Venovenous extracorporeal membrane oxygenation (VV-ECMO) is a therapeutic strategy for the coronavirus disease 2019 (COVID-19) induced acute respiratory distress syndrome (ARDS). There are inconclusive data in this regard and causes of VV-ECMO failure not yet understood well. Case Series Here, seven patients with COVID-19-induced ARDS who underwent introduced discussed. Medical records COVID-19 treated were retrospectively evaluated to determine clinical outcomes VV-ECMO....
Recent studies have provided evidence that the secretory cells of fallopian tube (oviduct) are a probable origin for high-grade serous ovarian carcinoma. In addition to cells, epithelium consists ciliated and CD44+ undifferentiated stem-like cells. Loss PAX2 expression is recognized as an early event in epithelial transformation, but specific role this transition unknown. The aim study was define oviductal (OVE) its response transforming growth factor β1 (TGFβ), characterizing specifically...
Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis. Despite the availability of novel therapeutic approaches, TB considered as one leading causes death due to infectious diseases worldwide. Alveolar macrophages are first line defense against M. tuberculosis; they ingest and sequester bacilli within granulomatous structures. Control resolution infection requires activated T lymphocytes well Th1 cytokines. There two forms TB: active latent TB. Latent state in which...
Despite negative association between 25-hydroxy vitamin D and incidence of many chronic respiratory diseases, this feature was not well studied in sarcoidosis. Current study investigated the deficiency with sarcoidosis chronicity, disease activity, extra-pulmonary skin manifestations, urine calcium level pulmonary function status Iranian patients. Results along future studies, will supply more effective programs for treatment.Eighty patients two groups insufficient serum sufficient were...
Abstract Background NK cells are the most active innate immune in antiviral immunity, which impaired by SARS-COV2 infection. Infusion of allogeneic might be a complementary treatment to boost system function COVID-19 patients. In this project, we focused on patients with low inspiratory capacity (LIC). This project aims evaluate feasibility and safety cell infusion as an intervention for respiratory viral disease. Methods A non-blind two arms pilot study was designed conducted after signing...
Early prediction of COVID-19 mortality outcome can decrease expiration risk by alerting healthcare personnel to assure efficient resource allocation and treatment planning. This study introduces a machine learning framework for the using demographics, vital signs, laboratory blood tests (complete count (CBC), coagulation, kidney, liver, gas, general). 41 features from 244 patients were recorded on first day admission. In this study, first, in each eight categories investigated. Afterward,...