A5073040474- Renal and related cancers
- Testicular diseases and treatments
- Immune Cell Function and Interaction
- Ovarian cancer diagnosis and treatment
- Sarcoma Diagnosis and Treatment
- RNA modifications and cancer
- Economic and Financial Impacts of Cancer
- Reproductive Biology and Fertility
- Chemotherapy-induced organ toxicity mitigation
- Renal Transplantation Outcomes and Treatments
- Nigella sativa pharmacological applications
- Bioactive Compounds and Antitumor Agents
- Urological Disorders and Treatments
- Cancer Cells and Metastasis
- Neonatal Respiratory Health Research
- Urologic and reproductive health conditions
- Developmental Biology and Gene Regulation
- Organ Transplantation Techniques and Outcomes
- Global Cancer Incidence and Screening
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Advances in Oncology and Radiotherapy
- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- Hematopoietic Stem Cell Transplantation
King Fahad Specialist Hospital
2017-2024
University of Glasgow
2024
University of Ottawa
2017-2020
Ottawa Hospital
2017-2020
Ottawa Hospital Research Institute
2017-2020
Al-Ahliyya Amman University
2020
Max Delbrück Center
2020
University of Jordan
2020
Immune checkpoint inhibitors, including PD-L1 (programmed death ligand-1) inhibitors have well documented anticancer therapeutic effect in most types of cancers but its use the treatment ovarian cancer is not yet proven. The aim our study to explore predictive biomarkers and association with outcomes. We investigated role expressions tumor microenvironment cells immune stem different cancer.A total 119 surgical archived samples were collected from pathology department at King Fahad...
Cancer incidence in Saudi Arabia has recently shown an upward trend. Research efforts within the different cancer continuum are pivotal to strengthening control measures. Since research is evolving country, it crucial understand current challenges and implement defined interventions overcome them. The present qualitative study aimed assess barriers among researchers identify potential solutions from their perspectives.
Recent studies have provided evidence that the secretory cells of fallopian tube (oviduct) are a probable origin for high-grade serous ovarian carcinoma. In addition to cells, epithelium consists ciliated and CD44+ undifferentiated stem-like cells. Loss PAX2 expression is recognized as an early event in epithelial transformation, but specific role this transition unknown. The aim study was define oviductal (OVE) its response transforming growth factor β1 (TGFβ), characterizing specifically...
<title>Abstract</title> Background Ovarian germ cell tumors (OVGCTs) account for 28% of all diagnosed ovarian cancers, and malignant specifically approximately 13% cancers in Saudi Arabia. Although most tumor patients have a high survival rate, who experience recurrence poor prognosis present with more aggressive chemoresistant tumors. The use immunotherapeutic agents such as PD-L1/PD-1 inhibitors OVGCTs remains very limited because few studies described the immunological characteristics...
Abstract Objectives Breast cancer is the most commonly diagnosed invasive non-skin malignancy in women worldwide, and it leading cause of cancer-related deaths them. Nigella sativa Linn. seed oil has been found to be effective treatment as well having anti-cancer properties some other types cancers. The study looked into synergistic cytotoxic effects N. doxorubicin human breast cells (MCF-7). Methods was used evaluate its effect on cells, either alone or conjunction with doxorubicin....
In adult tissue, the paired box 2 (PAX2) protein is expressed in healthy oviductal, but not normal ovarian surface epithelial cells. PAX2 a subset of cases serous carcinoma; however, role initiation and progression cancer remains unknown. The aim present study was to determine biological effects expression cancerous By culturing cells that express 3D culture staining with vasculogenic mimicry markers such as CD31 PAS, it shown overexpression both induced formation vascular-like structures...
Ovarian germ cell tumors (OVGCTs) account for 28% of all diagnosed ovarian cancers, and malignant specifically approximately 13% cancers in Saudi Arabia. Although most tumor patients have a high survival rate, who experience recurrence poor prognosis present with more aggressive chemoresistant tumors. The use immunotherapeutic agents such as PD-L1/PD-1 inhibitors OVGCTs remains very limited because few studies described the immunological characteristics these This study is first to...
The development of Graft-Versus-Host Disease (GVHD) post-liver transplantation (LT) is an uncommon complication. GVHD occurs when immunocompetent donor lymphocytes originating from the transplanted liver mount a destructive immune response against immunocompromised recipient. Diagnosis post-LT represents major challenge due to lack standard criteria rarity condition. Therefore, diagnosis and initiation therapy are often delayed. Here, we report case one-year old child who developed two...
<h3>Background</h3> Ovarian germ cell tumours comprise 28% of all diagnosed ovarian cancers and malignant specifically account for around 13% in Saudi Arabia. Although most tumour patients have high survival rate, recurrence poor prognosis presented much more aggressive chemo resistant tumours. The use immunotherapeutic agents such as PD-L1/PD-1 inhibitors remains very limited because inadequate studies that describe the immunological characteristics these This study is first to investigate...
Abstract In adult tissues, PAX2 protein is expressed in normal oviductal epithelial cells (OVE) but not ovarian surface (OSE). Recent studies reported that serous carcinoma cases the role of enhancing cancer unrevealed yet. The aim this study to understand biological consequences after Pax2 overexpression mouse (MOSE) cells. We found MOSE induced formation vascular channels both vitro and vivo, which indicate a possible contribution progression by increasing supply nutrients tumor Citation...
Abstract In adult tissues, PAX2 protein is expressed in normal oviductal epithelial cells but not ovarian surface cells. Studies have reported that a subset of serous carcinoma cases the role initiation and progression cancer remains unknown. The aim this study was to understand biological consequences Pax2 expression cancerous mouse (MOSE) We found overexpression both induced formation vascular channels vitro vivo . results indicate possible contribution by increasing supply nutrients tumor