A5087312342- Hedgehog Signaling Pathway Studies
- Developmental Biology and Gene Regulation
- Wnt/β-catenin signaling in development and cancer
- Neuroscience and Neural Engineering
- Advanced Materials and Mechanics
- Epigenetics and DNA Methylation
- Nanowire Synthesis and Applications
- Graphene and Nanomaterials Applications
- MicroRNA in disease regulation
- Plant Reproductive Biology
- RNA Interference and Gene Delivery
- Silicon Nanostructures and Photoluminescence
- Ubiquitin and proteasome pathways
- Plant and Biological Electrophysiology Studies
- Hippo pathway signaling and YAP/TAZ
- Plant Molecular Biology Research
- Extracellular vesicles in disease
- Cellular transport and secretion
Centro de Biología Molecular Severo Ochoa
2014-2021
Universidad Autónoma de Madrid
2011-2021
Consejo Superior de Investigaciones Científicas
2013-2020
Morphogens regulate tissue patterning through their distribution in concentration gradients. Emerging research establishes a role for specialized signalling filopodia, or cytonemes, morphogen dispersion and signalling. Previously we demonstrated that Hedgehog (Hh) is transported via vesicles along cytonemes emanating from signal-producing cells to form gradient Drosophila epithelia. However, the mechanisms signal reception transfer are still undefined. Here, demonstrate protruding...
The conserved family of Hedgehog (Hh) signaling proteins plays a key role in cell–cell communication development, tissue repair, and cancer progression, inducing distinct concentration-dependent responses target cells located at short long distances. One simple mechanism for distance dispersal the lipid modified Hh is direct contact between cell membranes through filopodia-like structures known as cytonemes. Here we have analyzed Drosophila interaction glypicans Dally Dally-like protein,...
The engineering of surface patterns is a powerful tool for analyzing cellular communication factors involved in the processes adhesion, migration, and expansion, which can have notable impact on therapeutic applications including tissue engineering. In this regard, main objective research was to fabricate patterned textured surfaces at micron- nanoscale levels, respectively, with very different chemical topographic characteristics control cell-substrate interactions. For task,...
In this work nanostructured porous silicon (nanoPS) was used for the fabrication of surface micropatterns aiming at controlling cell adhesion and migration. particular, patterns nanoPS Si were engineered by high-energy ion-beam irradiation subsequent anodization. It found that human skeletal progenitor cells are sensitive to oneand two-dimensional focal is inhibited on areas. spite anti-fouling characteristics, studies with reduced areas show conform pathways favoring migration through...
Abstract The conserved family of Hedgehog (Hh) signaling proteins plays a key role in cell-cell communication development, tissue repair and cancer progression. These can act as morphogens, inducing responses dependent on the ligand concentration target cells located at distance. Hh are lipid modified thereby have high affinity for membranes, which hinders understanding their spreading across tissues. Direct contact between cell membranes by filopodia-like structures (also known cytonemes)...