A5021269876- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Testicular diseases and treatments
- Renal and related cancers
- Urologic and reproductive health conditions
- Urinary and Genital Oncology Studies
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Urological Disorders and Treatments
- Pelvic floor disorders treatments
- Genetic factors in colorectal cancer
- Cancer-related Molecular Pathways
- Prostate Cancer Diagnosis and Treatment
- Sexual Differentiation and Disorders
- Sarcoma Diagnosis and Treatment
- Endometriosis Research and Treatment
- Case Reports on Hematomas
- Prostate Cancer Treatment and Research
- Neuroblastoma Research and Treatments
- Diverticular Disease and Complications
- Vascular anomalies and interventions
- Glutathione Transferases and Polymorphisms
- Cancer Research and Treatments
- Dialysis and Renal Disease Management
Complejo Hospitalario Universitario de Albacete
2013-2024
University of Castilla-La Mancha
2003-2024
Hospital General Universitario de Albacete
2002-2024
Weatherford College
2008
Urology Team
2007
Cellular aspartate drives cancer cell proliferation, but signaling pathways that rewire biosynthesis to control growth remain largely unknown. Hypoxia-inducible factor-1α (HIF1α) can suppress tumor proliferation. Here, we discovered HIF1α acts as a direct repressor of involving the suppression several key aspartate-producing proteins, including cytosolic glutamic-oxaloacetic transaminase-1 (GOT1) and mitochondrial GOT2. Accordingly, suppresses production from both glutamine oxidation well...
Extracellular signal-regulated kinase 5 (ERK5), also known as big mitogen-activated protein (MAPK) 1, is implicated in a wide range of biologic processes, which include proliferation or vascularization. Here, we show that ERK5 degraded through the ubiquitin-proteasome system, process mediated by tumor suppressor von Hippel-Lindau (VHL) gene, prolyl hydroxylation-dependent mechanism. Our conclusions derive from transient transfection assays Cos7 cells, well study endogenous different...
Paragangliomas or extra-adrenal pheochromocytomas account for approximately 15% of all pheochromocytomas. They are usually found in an intradiaphragmatic location. the urinary bladder infrequent and represent 6% paragangliomas 0.06% tumors. We describe 2 cases attended to our center review literature with special attention treatment, since there is some controversy around management these Surgical options include partial total cystectomy transurethral resection, but no consensus regarding...
No AccessJournal of UrologyInvestigative Urology1 Feb 2012Role CYP1B1 Gene Polymorphisms in Bladder Cancer Susceptibility Antonio S. Salinas-Sánchez, María J. Donate-Moreno, María-Pilar López-Garrido, José M. Giménez-Bachs, and Julio Escribano Salinas-SánchezAntonio Salinas-Sánchez , Donate-MorenoMaría Donate-Moreno López-GarridoMaría-Pilar López-Garrido Giménez-BachsJosé Giménez-Bachs EscribanoJulio View All Author Informationhttps://doi.org/10.1016/j.juro.2011.10.063AboutFull TextPDF...
Objectives To fully clarify the role of Mitogen Activated Protein Kinase in therapeutic response to Sorafenib Renal Cell Carcinoma as well cell death mechanism associated this kinase inhibitor, we have evaluated implication several Kinases Carcinoma-derived lines. Materials and methods An experimental model lines (ACHN 786-O cells) was terms viability by MTT assay, induction apoptosis caspase 3/7 activity, autophagy LC3 lipidation, p62 degradation activity using phospho-targeted antibodies....
Ureteral herniation is a rare entity. We report the first case of extraperitoneal ureteral in pediatric en bloc renal graft causing obstructive uropathy. A 70-year-old, obese patient with an transplant was found to have ureterohydronephrosis right on magnetic resonance imaging. Nephrostomy insertion double-J catheter confirmed presence loop within inguinal tract. Surgery ureter through internal ring, crossing over spermatic cord. performed release, resection, reimplantation and hernioplasty....
Recurrent urinary tract infections (rUTIs) affect 5-10% of women, resulting in an enormous healthcare and society burden. Uromune® is a polybacterial sublingual vaccine with excellent clinical benefit rUTI prophylaxis. This study assesses the impact vaccination on resource use expenditures associated this pathology.A quasi-experimental, pretest-posttest, single center including women vaccinated real-life practice was performed. Variables were need resources, collected prospectively during...
Alterations in the p53 gene related to neoplastic progression were studied tumor tissue samples from patients with transitional cell carcinoma and correlated classic staging parameters. On this basis, biological characterization of was performed establish subgroups at high risk those a more favorable prognosis.This observational, analytical cross-sectional study included 115 divided into 4 homogeneous groups 1-control, 2-primary superficial carcinoma, 3-recurrent 4-infiltrative carcinoma....
<i>Objective:</i> To analyze the correlation between genotypic and phenotypic patterns of <i>p53</i> in patients with transitional cell carcinoma (TCC) urinary bladder. <i>Materials Methods:</i> Cross-sectional study 73 diagnosed TCC. DNA was obtained from tumor tissue to perform polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) exons 5–9 gene, automatic sequencing done on any mutated samples. Immunohistochemistry (IHC) also...
What's known on the subject? and What does study add? Bladder cancer susceptibility may be determined by genetic differences in activity of glutathione S-transferases, enzymes that regulate conversion exogenous carcinogens to excretable hydrophilic metabolites conjugation. The discrepancy results regarding association common polymorphisms complex diseases such as has raised scepticism this area research. Although evidence generally supports implication GSTM1 GSTT1 bladder cancer, there is...
<b><i>Objectives:</i></b> Recurrent urinary tract infections (R-UTIs) are very common amongst women, and alternatives to antibacterial prophylaxis necessary. This study evaluates the effectiveness of a sublingual bacterial vaccine for R-UTIs. <b><i>Methods:</i></b> We conducted quasi-experimental pretest-posttest 166 women diagnosed with Both before after start treatment vaccine, we analysed total number R-UTI episodes, urine culture results,...
No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Feb 2003Prognostic Implications p53 Gene Mutations in Bladder Tumors J.G. LORENZO-ROMERO, A.S. SALINAS-SÁNCHEZ, J.M. GIMÉNEZ-BACHS, F. SÁNCHEZ-SÁNCHEZ, J. ESCRIBANO-MARTÍNEZ, M. SEGURA-MARTÍN, I.R. HERNÁNDEZ-MILLÁN, and J.A. VIRSEDA-RODRÍGUEZ LORENZO-ROMEROJ.G. LORENZO-ROMERO More articles by this author , SALINAS-SÁNCHEZA.S. SALINAS-SÁNCHEZ GIMÉNEZ-BACHSJ.M. GIMÉNEZ-BACHS SÁNCHEZ-SÁNCHEZF. SÁNCHEZ-SÁNCHEZ ESCRIBANO-MARTÍNEZJ....
To analyse the implications of DNA mismatch repair genes hMLH1 and hMSH2 in sporadic renal cell carcinoma (RCC).Specimens tumour healthy tissue were collected from 89 patients treated for RCC. Another 95 blood samples taken individuals with no history cancer also analysed. After extraction PCR amplification, microsatellite instability (MSI) was determined using Bethesda panel, two exonic microsatellites TGFbRII BAX genes, D3S1611. The promoter methylation status investigated HpaII MspI...
<i>Objectives:</i> To assess the presence of <i>p53</i> gene mutations in superficial tumors urinary bladder (transitional cell carcinoma) and their relationship to classic prognostic factors for cancer recurrence progression. analyze implication these on P53 protein structure. <i>Materials Methods:</i> Observational, cross-sectional study 90 consecutive patients, 60 with transitional carcinoma (pTa pT1) 30 without neoplastic disease (control group)....