A5011694559- Adipose Tissue and Metabolism
- Stress Responses and Cortisol
- Circadian rhythm and melatonin
- Neurogenetic and Muscular Disorders Research
- Genetics, Aging, and Longevity in Model Organisms
- Endoplasmic Reticulum Stress and Disease
- Diet and metabolism studies
- Tryptophan and brain disorders
- Muscle activation and electromyography studies
- Behavioral Health and Interventions
- Muscle Physiology and Disorders
- Genetic Neurodegenerative Diseases
- Birth, Development, and Health
- Nuclear Receptors and Signaling
- Cerebral Palsy and Movement Disorders
- Neurological Disorders and Treatments
- Historical and Linguistic Studies
- Amyotrophic Lateral Sclerosis Research
- Liver Disease Diagnosis and Treatment
- Physical Activity and Health
- Biochemical effects in animals
- Metabolism and Genetic Disorders
- Coenzyme Q10 studies and effects
- Hereditary Neurological Disorders
- Biblical Studies and Interpretation
University of Missouri
2021-2025
University of Missouri Health System
2024
Vanderbilt University
2003
Abstract Extensive research has demonstrated endurance exercise to be neuroprotective. Whether these neuroprotective benefits are mediated, in part, by hepatic ketone production remains unclear. To investigate the role of on brain health during exercise, healthy 6‐month‐old female rats underwent viral knockdown rate‐limiting enzyme liver that catalyses first reaction ketogenesis: 3‐hydroxymethylglutaryl‐CoA synthase 2 (HMGCS2). Rats were then subjected either a bout acute or 4 weeks chronic...
Abstract Background While canonical anabolic and proteolytic pathways have been well examined in the context of skeletal muscle proteostasis, roles endoplasmic reticulum stress (ERS) induced unfolded protein response (UPR) are underappreciated. Thus, we aimed to determine whether aging and/or disuse atrophy rats altered ERS/UPR markers. Methods Results Soleus (SOL) plantaris (PLT) muscles 3-month-old (mo), 6 mo, 12 18 24 mo (9–10 per group, 48 total) were analyzed for UPR proteins with...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder marked by progressive motor neuron degeneration in the primary cortex (PMC) and spinal cord. Aging key factor ALS onset progression, with evidence suggesting that biological aging-a process involving cellular decline- far outpaces chronological aging ALS. This promotes senescent cell accumulation-marked irreversible cell-cycle arrest, impaired apoptosis, chronic inflammation-disrupting tissue homeostasis impairing...
Abstract Sarcopenia, the pathological age‐related decline in muscle mass and strength, compromises independence quality of life older adults. Currently, no effective treatments are available. To enhance translational research using aged mouse models, we developed validated weighted cart pull (WCP) as a novel assessment sustained motor function. The WCP test involved attaching to tail it climbed ramp ‘resting house’. Mass was increased incrementally until failure, defined either five...
Alzheimer's disease (AD) is the fifth leading cause of death in older adults, and treatment options are severely lacking. Recent findings demonstrate a strong relationship between skeletal muscle cognitive function, with evidence supporting that quality function positively correlated adults. Conversely, decreased associated threefold increased risk decline. Based on these observations, purpose this study was to investigate negative effects disuse [via model hindlimb immobilization (HLI)]...
Physical inactivity is the 4th leading cause of death globally and has been shown to significantly increase risk for developing Alzheimer’s Disease (AD). Recent work demonstrated that exercise prior breeding produces heritable benefits brains offspring, suggesting physical activity status previous generations could play an important role in one’s brain health their subsequent neurodegenerative diseases. Thus, our study aimed test hypothesis selective inactivity, or high activity, preference...
Mild cognitive impairment (MCI) designates the boundary area between function in natural aging and dementia, this is viewed as a therapeutic window to prevent occurrence of dementia. The current study investigated neurocognitive effects oral creatine (Cr) supplementation young female Wistar rats that received intracerebroventricular injections lipopolysaccharide (LPS) mimic MCI. Neuromolecular changes within dentate gyrus were analyzed following behavioral testing. We also both...
Neuroinflammation is an early detectable marker of mild cognitive impairment, the transition state between normal cognition and dementia. Resistance-exercise training can attenuate decline observed in patients with impairment. However, underlying mechanisms resistance effects are largely unknown. To further elucidate known health benefits from resistance-exercise training, we tested if could ameliorate lipopolysaccharide-induced neuroinflammation. Five-week-old female Wistar rats received...
Physical activity (PA) is a non-invasive, cost-effective means of reducing chronic disease. Most US citizens fail to meet PA guidelines, and individuals experiencing stress are less likely be physically active. To better understand the barriers maintaining active lifestyles, we sought determine extent which short- versus long-term increases stress- aversion-related markers in wild-type (WT) low voluntary running (LVR) rats, unique genetic model physical motivation. Here, tested effects 1 4...
Aging and disuse can impair skeletal muscle responses to stimuli are key drivers in dysregulated proteostasis. Such dysfunction lead an accumulation of misfolded proteins resulting endoplasmic reticulum stress (ERS) the unfolded protein response (UPR). While UPR blunts global translation enhances production chaperones foldases, little is known about ERS across lifespan contexts. Therefore, purposes this study were examine if: i) expression effector differ rats, ii) age-associated patterns...
Abstract Objective Charcot–Marie Tooth (CMT) is a hereditary neuropathy characterized by muscle weakness and fatigue with no approved therapies. Preclinical studies implicate neuromuscular junction (NMJ) transmission deficits in dysfunction CMT. This study aimed to evaluate NMJ function patients CMT types 1 2, determine whether enhancing can improve preclinical models. Methods First, an observational involving single fiber electromyography (SFEMG) clinical testing 2 healthy controls (HC) was...
Physical inactivity is the 4th leading cause of death globally and has been shown to significantly increase one’s risk for developing Alzheimer’s Disease (AD). A recent study by McGreevy et al. discovered that exercised father rats prior breeding transfer heritable benefits brains their offspring, suggesting physical activity status previous generations could play an important role in brain health subsequent neurodegenerative diseases. Thus, this aimed address effect intergenerational on...
Physical activity (PA) is a non-invasive, cost-effective means of reducing chronic disease. Most US citizens fail to meet PA guidelines, and individuals experiencing stress are less likely be physically active. To better understand the barriers maintaining active lifestyles, we sought determine extent which short- versus long-term increases stress- aversion-related markers in wild-type (WT) low voluntary running (LVR) rats, unique genetic model physical motivation. Here, tested effects 1-...