A5031806241- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Genetic Neurodegenerative Diseases
- Pain Mechanisms and Treatments
- Neuroscience and Neural Engineering
- Muscle Physiology and Disorders
- Muscle activation and electromyography studies
- Anesthesia and Sedative Agents
- Hemodynamic Monitoring and Therapy
- Mitochondrial Function and Pathology
- Myasthenia Gravis and Thymoma
- Conducting polymers and applications
- Integrated Circuits and Semiconductor Failure Analysis
- Lipoproteins and Cardiovascular Health
- Transcranial Magnetic Stimulation Studies
- Bipolar Disorder and Treatment
- Coronary Interventions and Diagnostics
- Neurological disorders and treatments
- Veterinary Pharmacology and Anesthesia
- Diabetic Foot Ulcer Assessment and Management
- Neurogenetic and Muscular Disorders Research
- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Non-Invasive Vital Sign Monitoring
Aarhus University
2013-2025
Doctors Company (United States)
2024
Senzime (Sweden)
2024
Martini Ziekenhuis
2024
Takeda (United States)
2024
Aarhus University Hospital
2020
Myasthenia gravis (MG) is a neuromuscular disease that results in compromised transmission of electrical signals at the junction (NMJ) from motor neurons to skeletal muscle fibers. As result, patients with MG have reduced function and present symptoms severe weakness fatigue. ClC-1 specific chloride (Cl − ) ion channel plays important roles regulating fiber excitability during intense exercise. Here, we show partial inhibition an orally bioavailable small molecule (NMD670) can restore rat...
Translational models for obstructive coronary artery disease are lacking. We aimed to develop a porcine model stenosis induced by bioresorbable stent (BRS) implantation in hypercholesterolemic proprotein convertase subtilisin/kexin-9 (PCSK9) minipigs. Fifteen PCSK9 minipigs were randomized percutaneous intervention with Magmaris, Absorb or Desolve BRS. Optical coherence tomography (OCT) scans performed at baseline and 6-months followed histology. Matched OCT analysis showed minimal lumen...
Experimental myotonia induced in rat muscle by ClC-1 chloride channel-inhibited has been shown to be related inversely extracellular concentrations of Mg(2+) and Ca(2+) ([Mg(2+) ]o [Ca(2+) ]o) within physiological ranges. Because this implicates a role for [Mg(2+)]o [Ca(2+)]o the variability symptoms among congenita patients, we searched similar effects on human muscle.Bundles fibers were isolated from abdominal rectus patients undergoing surgery. Myotonia was inhibition using 9-anthracene...
In myotonia congenita, loss of ClC-1 Cl- channel function results in skeletal muscle hyperexcitability and myotonia. Anti-myotonic treatment has typically targeted the voltage-gated sodium (Nav1.4). this study we explored whether 3 channel-modulating anti-epileptics can reduce isolated rat human muscle.Dissected muscles were rendered myotonic by inhibition. The ability drugs to suppress was then assessed from subclinical maximal clinical concentrations. Drug synergy determined using isobole...
Neuromuscular blocking agents are used commonly to induce skeletal muscle relaxation during surgery. While facilitates surgical procedures and tracheal intubation, adequate recovery of function after surgery is required support pulmonary function, even mild residual neuromuscular block increases the risk severe postoperative complications. involving can be monitored and, in addition, accelerated by use current antagonists (reversal agents), there a clear clinical need for safe drug...
<title>Abstract</title> Neuromuscular blocking agents (NMBAs) are commonly used to induce skeletal muscle relaxation during surgery. While facilitates surgical procedures and tracheal intubation, adequate recovery of function after surgery is required support pulmonary function, even mild residual neuromuscular block increases the risk severe postoperative complications. involving NMBAs can be monitored and, in addition, accelerated by use current antagonists (reversal agents), there a clear...
Abstract Objective Charcot–Marie Tooth (CMT) is a hereditary neuropathy characterized by muscle weakness and fatigue with no approved therapies. Preclinical studies implicate neuromuscular junction (NMJ) transmission deficits in dysfunction CMT. This study aimed to evaluate NMJ function patients CMT types 1 2, determine whether enhancing can improve preclinical models. Methods First, an observational involving single fiber electromyography (SFEMG) clinical testing 2 healthy controls (HC) was...
Aim: Diabetes Mellitus is a global public health challenge with major and potentially devastating complications, concomitant complications include retinopathy neuropathy due to hypoxia microvascular dysfunction. In this study, we investigated the effect of hyperbaric oxygen therapy as method transiently improve tissue oxygenation on diabetic in streptozotocin induced type-1 rat model (Wistar). Methods: Streptozotocin rats received 10 sessions 2-h exposures (pO2 = 309 kPa) over 2 weeks....
Measuring vital signs is central to medical practice, but they are difficult monitor in awake laboratory animals. We examined the feasibility of a noninvasive device for telemetric assessment respiration rate, heart temperature and movement pigs. Awake piglets were monitored continuously 31 h (interquartile range, 7) before ( n = 4) after 3) surgery. Data quality was sufficient determination all parameters. conclude that continuous, monitor- ing pigs possible by using evaluated device.
Abstract Introduction/Aims Both neuromuscular junction (NMJ) dysfunction and altered electrophysiological properties of muscle fibers have been reported in amyotrophic lateral sclerosis (ALS) patients. ALS‐related preclinical studies typically use rodent SOD1 G93A overexpression models, but translation to the human disease has challenged. The present work explored NMJ function cellular muscles rats. Methods Longitudinal compound action potentials (CMAPs) were performed Cellular evaluate...
Introduction The aim of this study was to build an implant and benchmark it for further improvement, specifically aimed measure periphery nerves in rats. nerve algorithm based on the Qtrac approach measurements excitability motor sensory nerves. This design designed enhanced function related diabetic neuropathy; a common sometime debilitating condition that eventually may result foot ulcers limb amputation. In order better treat prevent complications is great importance recognize autonomic...