A5039110409- Anesthesia and Sedative Agents
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Pain Management
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Airway Management and Intubation Techniques
- Intraoperative Neuromonitoring and Anesthetic Effects
- Pain Mechanisms and Treatments
- Nausea and vomiting management
- Spine and Intervertebral Disc Pathology
- Hemodynamic Monitoring and Therapy
- Muscle activation and electromyography studies
- Ion channel regulation and function
- Respiratory Support and Mechanisms
- Pediatric Pain Management Techniques
- EEG and Brain-Computer Interfaces
- Patient Safety and Medication Errors
- Tracheal and airway disorders
- Botulinum Toxin and Related Neurological Disorders
- Neuroscience and Neural Engineering
- Musculoskeletal pain and rehabilitation
- Pain Management and Opioid Use
- Intraocular Surgery and Lenses
- Head and Neck Surgical Oncology
- Pain Management and Treatment
Mayo Clinic in Florida
2016-2025
Jacksonville College
2016-2025
WinnMed
2007-2025
Senzime (Sweden)
2019-2024
Doctors Company (United States)
2019-2024
Children's Hospital Colorado
2024
University of Colorado Denver
2024
Emory University
2024
University of Florida
2002-2024
Aarhus University
2024
Background Traditionally, reversal of nondepolarizing neuromuscular blocking agents was achieved using acetylcholinesterase inhibitors, but these are unable to adequately reverse profound blockade. Sugammadex is a novel agent, reversing the effects rocuronium by encapsulation. This study assessed efficacy and safety sugammadex versus neostigmine for rocuronium-induced Methods phase III, randomized enrolled surgical patients, aged 18 yr or older with American Society Anesthesiologists...
Postoperative residual neuromuscular block is a frequent occurrence. Recent surveys of clinical practice in Europe suggest that blocking drugs are often administered without appropriate monitoring. No comparable survey has been undertaken the United States (US). From this survey, we compared current and attitudes between anesthesia practitioners US Europe.We conducted an Internet-based among Europe. The Anesthesia Patient Safety Foundation European Society Anaesthesiology e-mailed all their...
Patients undergoing vascular surgery have a high risk of suffering major postoperative cardiac events.Preoperative myocardial ischemia as detected by Holter monitoring identifies high-risk subgroup whose ischemia, similarly detected, seems to herald events. In this study, we determined whether systematic, patient-specific heart rate control with beta-adrenergic blocker therapy decreases the incidence among patients. A total 26 150 patients who underwent elective and were monitored...
Patients undergoing vascular surgery have a high risk of suffering major postoperative cardiac events.Preoperative myocardial ischemia as detected by Holter monitoring identifies high-risk subgroup whose ischemia, similarly detected, seems to herald events. In this study, we determined whether systematic, patient-specific heart rate control with beta-adrenergic blocker therapy decreases the incidence among patients. A total 26 150 patients who underwent elective and were monitored...
To study the role of inflammatory cytokines in initiation and persistence radiculopathy as seen humans, tumor necrosis factor α (TNF-α) was administered either to normal, uninjured L5 dorsal root ganglia (DRG) rats via a hole drilled through transverse process, or chronically compressed DRG hollow stainless steel rod inserted into intervertebral foramen. In other experiments, mixture soluble TNF receptors (sTNF-Rs: sTNF-RI±sTNF-RII) locally delivered acutely neutralize activity endogenous...
In patients who receive a nondepolarizing neuromuscular blocking drug (NMBD) during anesthesia, undetected postoperative residual block is common occurrence that carries risk of potentially serious adverse events, particularly pulmonary complications. There abundant evidence can be prevented when real-time (quantitative) monitoring with measurement the train-of-four ratio used to guide NMBD administration and reversal. Nevertheless, significant percentage anesthesiologists fail use...
Women make up an increasing proportion of the physician workforce in anaesthesia, but they are consistently under-represented leadership and governance.We performed internet-based survey to investigate career opportunities research amongst anaesthesiologists. We also explored gender bias attributable workplace attitudes economic factors. The instrument was piloted, translated into seven languages, uploaded SurveyMonkey® platform. aimed collect between 7800 13 700 responses from at least 100...
Local perfusion of the dorsal root ganglion (DRG) with tumor necrosis factor α (TNF-α) in rats induces cutaneous hypersensitivity to mechanical stimuli. Thus we investigated cellular mechanisms TNF-α-induced hyperalgesia. The L 4 and 5 DRGs sciatic nerves attached were excised from for vitro microfilament recording. After baseline recording 15 min, TNF-α (0.001, 0.01, 0.1, or 1 ng/ml) was applied DRG followed by washout at least 30 min. Alternatively, H-89 Rp-cAMPS, two specific...
Pain reduces itch - a commonly known effect of scratching the skin. Experimentally produced from histamine is sometimes accompanied by secondary sensations pain. The present study investigated effects eliminating this pain, means local anesthetic, on and enhanced mechanically evoked pain that occur after an intradermal injection histamine. In ten human subjects, volar forearm was injected with either 20 mul 2% chloroprocaine (experimental arm), or saline (control arm). Histamine 10 into each...
The analgesic efficacy and adverse effects of morphine oxymorphone in 32 patients who received traditional patient-controlled analgesia (PCA) following cesarean delivery were compared with those other receiving the same agents via PCA plus basal opioid infusion (PCA + BI). All operated upon during epidural anesthesia 2% lidocaine 1:200,000 epinephrine to achieve a T4 sensory level. Upon first complaint pain recovery room, given titrated iv loading dose assigned until comfortable then...
Background The paucity of easy-to-use, reliable objective neuromuscular monitors is an obstacle to universal adoption routine monitoring. Electromyography (EMG) has been proposed as the optimal monitoring technology since it addresses several acceleromyography limitations. This clinical study compared simultaneous responses recorded from induction block until recovery using acceleromyography-based TOF-Watch SX and EMG-based TetraGraph. Methods Fifty consenting patients participated. EMG...
Proinflammatory cytokines may sensitize primary sensory neurons and facilitate development of neuropathic pain processes after peripheral nerve injury. The goal this study was to determine whether responses dorsal root ganglion (DRG) exogenous tumor necrosis factor alpha (TNF-alpha) are altered in a chronically compressed DRG (CCD) injury model. Extracellular recordings from teased microfilaments demonstrated that acute topical application TNF-alpha the for 15 min evoked C- Abeta-fiber both...