A5055402402- Muscle Physiology and Disorders
- Adipose Tissue and Metabolism
- Nutrition and Health in Aging
- Tissue Engineering and Regenerative Medicine
- Muscle metabolism and nutrition
- Pesticide and Herbicide Environmental Studies
- Autophagy in Disease and Therapy
- Genetics, Aging, and Longevity in Model Organisms
- Metabolism, Diabetes, and Cancer
- Telomeres, Telomerase, and Senescence
- Exercise and Physiological Responses
- GDF15 and Related Biomarkers
- Plant nutrient uptake and metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Plant responses to elevated CO2
- Mesenchymal stem cell research
- Diet and metabolism studies
- Weed Control and Herbicide Applications
- Sirtuins and Resveratrol in Medicine
- Ubiquitin and proteasome pathways
- Cardiomyopathy and Myosin Studies
- Pluripotent Stem Cells Research
- Soil Carbon and Nitrogen Dynamics
- FOXO transcription factor regulation
- Children's Physical and Motor Development
James Cook University
2017-2024
Australian Institute of Tropical Health and Medicine
2021-2024
Singapore Institute for Clinical Sciences
2011-2021
Agency for Science, Technology and Research
2011-2021
National University of Singapore
2014
Nanyang Technological University
2008-2014
University of Waikato
2005-2007
AgResearch
2004-2007
Environmental Protection Agency
1982-1994
Corvallis Environmental Center
1982-1991
Abstract Myostatin, a transforming growth factor‐beta (TGF‐β) super‐family member, has been well characterized as negative regulator of muscle and development. Myostatin implicated in several forms wasting including the severe cachexia observed result conditions such AIDS liver cirrhosis. Here we show that induces by mechanism independent NF‐κB. treatment resulted reduction both myotube number size vitro, loss body mass vivo. Furthermore, expression myogenic genes myoD pax3 was reduced,...
Exercise induces expression of the myokine irisin, which is known to promote browning white adipose tissue and has been shown mediate beneficial effects following exercise. Here we show that irisin a number pro-myogenic exercise response genes in myotubes. Irisin increases myogenic differentiation myoblast fusion via activation IL6 signaling. Injection mice significant hypertrophy enhances grip strength uninjured muscle. Following skeletal muscle injury, injection improves regeneration...
The causes of impaired skeletal muscle mass and strength during aging are well-studied in healthy populations. Less is known on pathological age-related wasting weakness termed sarcopenia, which directly impacts physical autonomy survival. Here, we compare genome-wide transcriptional changes sarcopenia versus age-matched controls biopsies from 119 older men Singapore, Hertfordshire UK Jamaica. Individuals with reproducibly demonstrate a prominent signature mitochondrial bioenergetic...
Introduction / Stefan Trapp and J. Craig Mc Farlane --Anatomy physiology of plant conductive systems -- Principles governing uptake transport chemicals Richard H. Bromilow Keith Chamberlain Metabolic processes for organic in plants Dieter Komossa, Christian Langebartels, Heinrich Sandermann, Jr. Model xenobiotics into Partitioning between the atmopsheric environment leaves Markus Riederer Interpreting chemical partitioning soil-plant-air with a fugacity model Sally Paterson Donald Mackay...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Model of Organic Chemical Uptake by Plants from Soil and the AtmosphereSally. Paterson, Donald. Mackay, Craig. McFarlaneCite this: Environ. Sci. Technol. 1994, 28, 13, 2259–2266Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December 1994https://pubs.acs.org/doi/10.1021/es00062a009https://doi.org/10.1021/es00062a009research-articleACS PublicationsRequest reuse permissionsArticle...
Summary Abnormal levels of reactive oxygen species (ROS) and inflammatory cytokines have been observed in the skeletal muscle during wasting including sarcopenia. However, mechanisms that signal ROS production prolonged maintenance are not fully understood. Here, we show myostatin (Mstn) is a pro‐oxidant signals generation cells. Myostatin, transforming growth factor‐β (TGF‐β) family member, has shown to play an important role by increasing protein degradation. Our results here Mstn induces...
Ubiquitination-mediated proteolysis is a hallmark of skeletal muscle wasting manifested in response to negative growth factors, including myostatin. Thus, the characterization signaling mechanisms that induce ubiquitination intracellular and sarcomeric proteins during great importance. We have recently characterized myostatin as potent regulator myogenesis further demonstrated elevated levels circulation results up-regulation muscle-specific E3 ligases, Atrogin-1 ring finger protein 1...
Atrogin-1, a muscle-specific E3 ligase, targets MyoD for degradation through the ubiquitin-proteasome-mediated system. Myostatin, member of transforming growth factor-β superfamily, potently inhibits myogenesis by lowering levels. While atrogin-1 is upregulated myostatin, it currently unknown whether plays role in mediating myostatin signaling to regulate myogenesis. In this report, we have confirmed that increasingly interacts with upon recombinant human (hMstn) treatment. The absence...
Abstract This paper documents a conceptual model for the uptake of anthropogenic organic chemicals into plants. The describes dynamic from soil, solution, or atmosphere, and metabolism accumulation xenobiotic in roots, stems, leaves, fruits. goal was to develop an easy rapid tool that would be numerically stable require only few well-known input data. is applicable different plant species most (nondissociating) chemicals. Processes considered are (a) diffusive exchange, soil/roots,...
Myostatin, a member of the transforming growth factor-β superfamily, has been implicated in potent negative regulation myogenesis murine models. However, little is known about mechanism(s) through which human myostatin negatively regulates skeletal muscle growth. Using primary myoblasts and recombinant protein, we show here that blocks myoblast proliferation by regulating cell cycle progression targeted upregulation p21. We further myogenic differentiation inhibition key regulatory factors...
Myostatin is a negative regulator of skeletal muscle growth and in fact acts as potent inducer "cachectic-like" wasting mice. The mechanism action myostatin promoting has been predominantly studied murine models. Despite numerous reports linking elevated levels to human conditions, little currently known about the signaling mechanism(s) through which promotes wasting. Therefore, this present study we describe further detail mechanisms behind regulation using an vitro primary myotube atrophy...
Humoral and tumoral factors collectively promote cancer-induced skeletal muscle wasting by increasing protein degradation. Although several humoral proteins, namely TNFα (tumour necrosis factor α) IL (interleukin)-6, have been shown to induce wasting, there is a lack of information regarding the that contribute atrophy during cancer cachexia. Therefore, in present study, we characterized secretome C26 colon cells identify involved wasting. In show myostatin, procachectic TGFβ (transforming...
Growth factors, such as myostatin (Mstn), play an important role in regulating post-natal myogenesis. In fact, loss of Mstn has been shown to result increased muscle growth through enhanced satellite cell functionality; while elevated levels dramatic skeletal wasting a mechanism involving reduced protein synthesis and ubiquitin-mediated degradation. Here we show that miR-27a/b plays feed back auto-regulation thus regulation Sequence analysis 3' UTR showed single highly conserved binding site...
Myostatin (Mstn) has a pivotal role in glucose and lipid metabolism. Mstn deficiency leads to the increased browning of white adipose tissue (WAT), which results energy expenditure protection against diet-induced obesity insulin resistance. In this study, we investigated molecular mechanism(s) through regulates adipocytes.Quantitative analyses were performed assess regulation miR-34a Fndc5 expression. was overexpressed repressed investigate Fndc5. Luciferase reporter analysis verified direct...
Parkinson's disease is a neurodegenerative characterized by tremors, muscle stiffness, and weakness. Molecular genetic analysis has confirmed that mutations in PARKIN PINK1 genes, which play major roles mitochondrial quality control mitophagy, are frequently associated with disease. an E3 ubiquitin ligase translocates to mitochondria during loss of membrane potential increase mitophagy. Although dysfunction noted disease, little known about the involvement phenotype In this study, we report...