A5058564320- Fatty Acid Research and Health
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Cancer, Lipids, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Metabolomics and Mass Spectrometry Studies
- Lipid metabolism and disorders
- Cholesterol and Lipid Metabolism
- Education, Psychology, and Social Research
- Lipid metabolism and biosynthesis
- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nutrition, Genetics, and Disease
- Plant Pathogens and Fungal Diseases
- Antioxidant Activity and Oxidative Stress
- Metabolism and Genetic Disorders
- Paraoxonase enzyme and polymorphisms
- Muscle metabolism and nutrition
- Nutritional Studies and Diet
- Algal biology and biofuel production
- Adipokines, Inflammation, and Metabolic Diseases
- Plant Disease Management Techniques
- Vitamin C and Antioxidants Research
Charles University
2015-2024
General University Hospital in Prague
2012-2024
Mendel University in Brno
2012-2014
n-3 polyunsaturated fatty acids, namely docosahexaenoic acid (DHA) and eicosapentaenoic (EPA), reduce the risk of cardiovascular disease can ameliorate many obesity-associated disorders. We hypothesised that latter effect will be more pronounced when DHA/EPA is supplemented as phospholipids rather than triglycerides.
Polyunsaturated fatty acids of n-3 series (n-3 PUFA) were shown to increase basal fat oxidation in humans. The aim the study was compare effect PUFA added a very low calorie diet (VLCD), with VLCD only during three-week inpatient weight reduction. Twenty severely obese women randomly assigned or placebo. Fatty serum lipid fractions quantified by gas chromatography. Differences between groups determined using ANOVA. Higher (7.55+/-1.77 vs. 6.07+/-2.16 kg, NS), BMI (2.82+/-0.62 2.22+/-0.74,...
Elevated circulating lipid levels are known risk factors for cardiovascular diseases (CVD). In order to examine the effects of quercetin on metabolism, mice received a mild-high-fat diet without (control) or with supplementation 0.33% (w/w) 12 weeks. Gas chromatography and (1)H nuclear magnetic resonance were used quantitatively measure serum profiles. Whole genome microarray analysis liver tissue was identify possible mechanisms underlying altered levels. Body weight, energy intake hepatic...
Oxidative stress has been implicated in the pathogenesis of chronic pancreatitis (CP) and pancreatic cancer (PC). The study aim was to assess oxidative markers antioxidant defense system patients with CP those PC.Activities superoxide dismutase 1 (SOD1), catalase (CAT), glutathione peroxidase (GPX1), reductase (GR), arylesterase (PON1-A) lactonase (PON1-L) activities paraoxonase (PON1) concentrations reduced glutathione, conjugated dienes low-density lipoprotein (CD/LDL) oxidized LDL...
The unicellular green microalga Dunaliella is a potential source of wide range nutritionally important compounds applicable to the food industry. aim this study was assess effect salina dried biomass on growth and adherence 10 strains Lactobacillus, Lacticaseibacillus, Bifidobacterium. immunomodulatory, antioxidant, cytotoxic effects D. human peripheral mononuclear cells simulated intestinal epithelial cell lines Caco-2 HT-29 were evaluated. Furthermore, hypocholesterolemic microalgae lipid...
Pancreatic cancer (PC) ranks as the fourth cause of cancer-related deaths in Czech Republic. Evidence exists that deregulation fatty acid (FA) metabolism is connected with some malignancies; therefore, we decided to analyze FA profile plasma lipid classes patients PC relation tumor staging, nutritional status, and survival. The study included 84 (47 males, 37 females) 68 controls (36 32 females). patterns were analyzed by gas-chromatography. We observed increased proportion total...
<b><i>Objective: </i></b>In the pathogenesis of metabolic syndrome (MetS), an increase oxidative stress could play important role which is closely linked with insulin resistance, endothelial dysfunction, and chronic inflammation. The aim our study was to assess several parameters antioxidant status in MetS. <b><i>Methods: </i></b>40 subjects MetS 40 age- sex-matched volunteers without were examined for activities superoxide dismutase (CuZnSOD),...
Fatty acid composition of adipose tissue changes with weight loss. Palmitoleic as a possible marker endogenous lipogenesis or its functions lipokine are under debate. Objective was to assess the predictive role triglycerides fatty acids in maintenance participants DIOGENES dietary intervention study. After an 8-week low calorie diet (LCD) subjects > 8 % loss were randomized 5 ad libitum diets for 6 months: protein (P)/low glycemic index (GI) (LP/LGI), P/high GI (LP/HGI), high P/low...
The selenium (Se) enrichment of yeasts and lactic acid bacteria (LAB) has recently emerged as a novel concept; the individual health effects these beneficial microorganisms are combined by supplying essential micronutrient Se in more bioavailable less toxic form. This study investigated bioavailability strains Enterococcus faecium CCDM 922A (EF) Streptococcus thermophilus 144 (ST) their respective Se-enriched forms, SeEF SeST, CD (SD-Sprague Dawley) IGS rat model. LAB administration resulted...
Monounsaturated fatty acids (MUFA) are understood to have therapeutic and preventive effects on chronic complications associated with type 2 diabetes mellitus (T2DM); however, there differences between individual MUFAs. Although the of palmitoleic acid (POA) still debated, POA can regulate glucose homeostasis, lipid metabolism, cytokine production, thus improving metabolic disorders. In this study, we investigated compared oleic (OA) supplementation insulin sensitivity, inflammation in a...
Anorexia nervosa is a model of simple starvation accompanied by secondary hyperlipoproteinemia. The pattern plasma fatty acids influences the levels lipids and lipoproteins. concentration lathosterol surrogate marker cholesterol synthesis de novo, concentrations campesterol beta-sitosterol reflect resorption exogenous cholesterol. aim study was to evaluate in lipid classes their relationship lipids, lipoproteins, precursors plant sterols. We examined 16 women with anorexia 25 healthy ones....
The prevalence of metabolic syndrome as well the occurrence depressive disorder, which are both connected with increased risk diabetes mellitus type 2 and cardiovascular diseases, is continually increasing worldwide. These disorders interconnected at various levels; genetic one seems to be promising. Contribution factors aetiopathogenesis disorder weighs within range 40–50 %, whereas background for manifestation more complicated. In this pilot study, we investigated incidence polymorphisms...