A5075211228- Diet and metabolism studies
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Connective Tissue Growth Factor Research
- Adipokines, Inflammation, and Metabolic Diseases
- Circadian rhythm and melatonin
- Pancreatic function and diabetes
- Dietary Effects on Health
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Nutrition, Genetics, and Disease
- GDF15 and Related Biomarkers
- Cancer, Lipids, and Metabolism
- Diabetes Treatment and Management
- Fibroblast Growth Factor Research
- Hormonal Regulation and Hypertension
- Nutritional Studies and Diet
- Biochemical Analysis and Sensing Techniques
- Food composition and properties
- Nutrition and Health in Aging
- Diabetes Management and Research
- Cancer, Hypoxia, and Metabolism
University of Zurich
2022-2023
Spital Linth
2017-2022
Spital STS
2022
Charité - Universitätsmedizin Berlin
2012-2021
German Center for Diabetes Research
2015-2021
Heinrich Heine University Düsseldorf
2015-2021
Deutsches Diabetes-Zentrum e.V.
2015-2021
German Institute of Human Nutrition
2012-2021
Freie Universität Berlin
2021
Humboldt-Universität zu Berlin
2021
WISP1 (Wnt1-inducible signaling pathway protein-1, also known as CCN4) is a member of the secreted extracellular matrix–associated proteins CCN family and target gene Wingless-type (WNT) pathway. Growing evidence links WNT to regulation adipogenesis low-grade inflammation in obesity. We aimed validate novel adipokine. Human adipocyte differentiation was associated with increased expression secretion. Stimulation human macrophages led proinflammatory response. Circulating subcutaneous adipose...
Natriuretic peptides (NP) regulate cardiovascular homeostasis and have multiple metabolic properties. Decreased levels of NP or "natriuretic handicap" are signs insulin resistance such as central obesity. Increased expression clearance receptor (NPRC) in sc adipose tissue (SAT) was observed insulin-resistant subjects. We hypothesized that acutely regulates tissue. NPRA, NPRB, NPRC mRNA measured paired samples visceral (VAT) SAT from 157 subjects (108 with type 2 diabetes). The effect on NPR...
The circadian clock coordinates numerous metabolic processes with light-dark and feeding regimens. However, in humans it is unknown whether dietary patterns influence rhythms. We examined the effects of switching from a high-carbohydrate, low-fat diet to low-carbohydrate, high fat (LC/HFD) isocaloric on central peripheral clocks humans. Diurnal salivary cortisol gene expression were analyzed blood monocytes 29 nonobese healthy subjects before 1 6 weeks after switch. For this, we established...
Insulin clearance is decreased in type 2 diabetes mellitus (T2DM) for unknown reasons. Subjects with metabolic syndrome are hyperinsulinemic and have an increased risk of T2DM. We aimed to investigate the relationship between hepatic insulin (HIC) different components tested hypothesis that HIC may predict syndrome.Individuals without from Metabolic Syndrome Berlin Brandenburg (MeSyBePo) study (800 subjects baseline examination 189 MeSyBePo recall study) underwent oral glucose tolerance test...
To compare high animal protein (AP) with plant (PP) diets, differing in amino acid composition, people type 2 diabetes (T2DM).We compared isocaloric diets containing 30% of energy either as AP or PP, using newly developed PP-enriched foods, both combined fat and 40% carbohydrates 44 patients T2DM over 6 weeks a randomized parallel-group study. Insulin sensitivity was assessed by hyperinsulinaemic-euglycaemic clamps cardiovascular variables were measured.Uric decreased groups, but...
Our objective was to study whether young first-degree relatives of patients with type 2 diabetes (FDRs) have altered insulin secretion and clearance in response gastric inhibitory polypeptide (GIP) combination glucose arginine. A hyperglycemic clamp (11.1 mmol/l for 115 min), followed by addition GIP (2 pmol · kg−1 min−1, 60–115 min) an arginine bolus infusion (10 mg 90–115 conducted on 14 healthy volunteers 13 FDRs. Both groups had normal tolerance. FDRs were more resistant (HOMAIR) under...
Diets high in cereal-fiber (HCF) have been shown to improve whole-body insulin sensitivity. In search for potential mechanisms we hypothesized that a supplemented HCF-diet influences the composition of human gut microbiota and/or biomarkers colonic carbohydrate fermentation.We performed randomized controlled 18-week intervention group-matched overweight participants. Fecal samples 69 participants receiving isoenergetic HCF (cereal-fiber 43 g/day), or control 14 high-protein (HP, 28%...
Glucose-dependent insulinotropic polypeptide (GIP) has been suggested to have direct effects on nonislet tissues. GIP also reportedly increased glucose uptake and inhibition of lipolysis in adipocytes after the intracellular cortisone-cortisol shuttle 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). We here analyzed whether modifies lipid metabolism further elucidated relation between GIP, 11β-HSD1, fatty acid metabolism. reduced activity 11β-HSD1 promoter constructs expression...
Abstract Diurnal carbohydrate and fat distribution modulates glycaemic control in rodents. In humans, the optimal timing of both macronutrients its effects on after prolonged consumption are not studied detail. this cross-over trial, 29 non-obese men were randomized to two four-week diets: (1) carbohydrate-rich meals until 13.30 fat-rich between 16.30 22.00 (HC/HF) versus (2) inverse sequence (HF/HC). After each trial period meal tolerance tests performed, at 09.00 15.40, respectively,...
Diabetes mellitus type 2 (T2DM), insulin therapy, and hyperinsulinemia are independent risk factors of liver cancer. Recently, the use a novel inhibitor degrading enzyme (IDE) was proposed as new therapeutic strategy in T2DM. However, IDE inhibition might stimulate cell proliferation via increased intracellular concentration. The aim this study to characterize effects activity HepG2 hepatoma cells analyze specific expression subjects with were treated 10 nM for 24 h or without using RNAi,...
Wingless-type (Wnt) inducible signalling pathway protein-1 (WISP1) has been recently identified as a proinflammatory adipokine. We examined whether WISP1 expression and circulating levels are altered in type 2 diabetes affects insulin muscle cells hepatocytes. Serum visceral adipose tissue (VAT) biopsies, for analysis of by ELISA mRNA real-time quantitative RT-PCR, were collected from normal-weight men (control group, n = 33) obese with (n 46) without 56) undergoing surgery. Following...
The consumption of arabinoxylan, a soluble fibre fraction, has been shown to improve glycemic control in type 2 diabetic subjects. Soluble dietary may modulate gastrointestinal or adipose tissue hormones regulating food intake. present study investigated the effects arabinoxylan on serum glucose, insulin, lipids, leptin, adiponectin and resistin subjects with impaired glucose tolerance. In randomized, single-blind, controlled, crossover intervention trial, 11 adults consumed white bread...
Amino-acid (AA) metabolic signatures differ in insulin-resistant (IR) obese vs normal-weight subjects, improve after weight loss, and seem to predict the risk of type 2 diabetes. It is unknown whether weight-maintaining dietary measures aimed at influencing IR alter AA high-risk subjects. In randomized controlled Protein, Fiber Metabolic Syndrome (ProFiMet) trial we investigated effects four isoenergetic, moderately fat-reduced diets varying protein cereal-fiber contents on complete 76...