A5101833190- Ear Surgery and Otitis Media
- Viral Infections and Vectors
- Malaria Research and Control
- Mosquito-borne diseases and control
- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Histiocytic Disorders and Treatments
- Head and Neck Anomalies
- Radiomics and Machine Learning in Medical Imaging
- Cervical Cancer and HPV Research
- Traditional Chinese Medicine Studies
- Cancer-related molecular mechanisms research
- Ear and Head Tumors
- MicroRNA in disease regulation
- Cervical and Thoracic Myelopathy
- Trace Elements in Health
- Adenosine and Purinergic Signaling
- Sinusitis and nasal conditions
- Mercury impact and mitigation studies
- Cancer-related gene regulation
- Hearing, Cochlea, Tinnitus, Genetics
- Musculoskeletal synovial abnormalities and treatments
- Facial Nerve Paralysis Treatment and Research
- Spine and Intervertebral Disc Pathology
- Nasal Surgery and Airway Studies
Guiyang Medical University
2020-2024
Zunyi Medical University
2019-2024
Chongqing University
2024
Donghua University
2024
Liuzhou General Hospital
2023
Xijing Hospital
2018
University of the Ryukyus
2014
Zhujiang Hospital
2014
Southern Medical University
2014
Luoyang Institute of Science and Technology
2013
The evolution of dengue virus (DENV) is characterized by phylogenetic trees that have a strong temporal structure punctuated dramatic changes in clade frequency. To determine the cause these large-scale patterns, we examined evolutionary history DENV serotype 1 (DENV-1) and DENV-3 Thailand, where gene sequence epidemiological data are relatively abundant over 30-year period. We found evidence for turnover viral clades both serotypes, most notably DENV-1, major replacement event took place...
Ferroptosis in neurons is considered one of the key factors that induces Parkinson's disease (PD), which caused by excessive iron accumulation intracellular labile pool (LIP). The ions released from LIP lead to aberrant generation reactive oxygen species (ROS) trigger ferroptosis and exacerbate PD progression. Herein, a pioneering design multifunctional nanoregulator deferoxamine (DFO)-integrated nanosheets (BDPR NSs) presented target restrict protect against PD. BDPR NSs are constructed...
To investigate the prevalence, genotypes, and prognostic values of Epstein-Barr virus (EBV) human papillomavirus (HPV) infections in Japanese patients with different types head neck cancer (HNC).HPV EBV DNA, genotypes LMP-1 variants, HPV mRNA expression were detected by PCR from fresh-frozen HNC samples. determined direct sequencing, encoded RNA (EBER) was examined situ hybridization.Of 209 patients, 63 (30.1%) had infection, HPV-16 most common subtype (86.9%). E6/E7 found 23 60 (38.3%)...
Disruption of neuronal iron homeostasis and oxidative stress are related to the pathogenesis Parkinson's disease (PD). Alpha-lipoic acid (ALA), a naturally occurring enzyme cofactor with antioxidant chelator properties, has many known effects. It is that ALA neuroprotective effects on PD, but its underlying mechanism remains unclear. In present study, we established PD models induced by 6-hydroxydopamine (6-OHDA) explore ability in vivo vitro. Our results showed could provide significant...
Abstract Background Head and neck squamous cell carcinoma (HNSCC) is the 6th most common malignant cancer type worldwide. Radiosensitivity has been shown to be significantly increased in patients with human papillomavirus (HPV)-positive HNSCC compared HPV-negative patients. However, clinical significance of HPV its regulatory mechanisms are largely unknown. The aim our study was explore mechanism miR-27a-3p radiosensitivity HPV-positive cells. Methods E6-overexpressing E6-knockdown lines...
The aim of this study is to describe the clinical characteristics and intraoperative findings further evaluate efficacy endoscopic ossiculoplasty for management isolated congenital ossicular chain malformation.A retrospective was performed on 16 ears (15 patients) with malformation who underwent in our department from May 2017 January 2019. Endoscopic exploratory tympanotomy conducted check chain; at same time, depending findings. Air-conduction thresholds, bone-conduction air-bone gaps...
T492I, a mutation encountered in SARS-CoV-2 nonstructural protein 4 (NSP4), enhances viral replication and alters cleavage, causing potential evolutionary impacts. Through comprehensive comparative analyses based on evolve-and-resequence experiments of wild-type Delta strains with or without we demonstrate that NSP4 T492I not only increases the rate, but also accelerates emergence many mutations characteristic for Omicron variants. Accordingly, populations evolved from ancestors show...
Hypopharyngeal lipoma is a rare disease that can lead to asphyxiation after aspiration. Sclerotic in the hypopharynx an extremely histological type. should be resected time diagnosis.An 86-year-old female patient presented our department with long pedunculated mass protruding from her mouth. Until this time, had no dyspnea, dysphagia, or throat discomfort. Physical examination showed stable vital signs and clear consciousness. The pedicel was derived posterior wall of hypopharynx. tumor...
Objective To investigate the microsurgical methods for early stage of ruptured intracranial multiple aneurysms. Methods Twenty-three cases aneurysms were selected, through pterion craniotomy, all them operated within 72 h attack. After modified Paine point ventricle puncture cerebrospinal fluid, and emergency clip closed rupture aneurysm in 49 cases, parcel two cases. Results Twenty-three craniotomy patients placed successfully 50 (the clipped three one time clipping 15 wrapped...
Objective To investigate the curative effective of specific immunotherapy drugs dermatophagoides farinae drops on children with allergic asthma.Methods One hundred and sixty-two asthma were divided into two groups randomly.The 84 patients in treatment group treated buccaled desensitizing drug.The 78 control inhalation drug simply.The influence lung function evaluated.Results After 36 weeks treatment,the was obviously better than attack frequency.Conclusions The is remarkable. Key words:...
Abstract The incidence of incomplete partition Type I inner ear malformation is very low; therefore, bacterial meningitis caused by this also rare. Here, we report a case such patient. This young female patient, who 7 years old, began to have recurrent headaches, and after 5 years, chest back pain. doctor diagnosed meningitis, the anti‐infection treatment was effective. She followed up annually continued outbreaks repeatedly for 17 but cause repeated infection not found. After detailed...