A5047420332- Vibrio bacteria research studies
- Viral gastroenteritis research and epidemiology
- Vaccine Coverage and Hesitancy
- Escherichia coli research studies
- Influenza Virus Research Studies
- Hepatitis Viruses Studies and Epidemiology
- Hepatitis B Virus Studies
- Mosquito-borne diseases and control
- Viral Infections and Outbreaks Research
- Viral Infections and Vectors
- Salmonella and Campylobacter epidemiology
- Cervical Cancer and HPV Research
- Virus-based gene therapy research
- Disaster Response and Management
- Health and Conflict Studies
- Child Nutrition and Water Access
- Malaria Research and Control
- Global Public Health Policies and Epidemiology
- Reproductive tract infections research
- Genital Health and Disease
- Liver Disease and Transplantation
- Ethics in Clinical Research
- Adolescent Sexual and Reproductive Health
- Lymphoma Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
International Vaccine Institute
2018-2025
Massachusetts General Hospital
2021
Texas A&M University
2016-2020
Mitchell Institute
2020
Walter Reed Army Institute of Research
2009-2013
United States Army Medical Research and Development Command
2010
Wilford Hall Ambulatory Surgical Center
2002-2007
Joint Base San Antonio
2006
University of Southern California
2004
Brooke Army Medical Center
2002-2003
Hepatitis E is likely the most common cause of acute viral hepatic disease globally.It estimated that over 900 million people have been infected with hepatitis virus (HEV), equivalent to nearly 1 in 8 individuals worldwide [1].Available evidence suggests 20 are annually resulting 70,000 deaths [2].Considering limited availability diagnostics, insufficient surveillance, and investigation outbreaks, these significant underestimates.Although there only a single HEV serotype, 4 different...
In October, 2017, WHO launched a strategy to eliminate cholera by 2030. A primary challenge in meeting this goal is the limited global supply capacity of oral vaccine and worsening outbreaks since 2021. To help address current shortage vaccine, prequalified Euvichol-Plus was reformulated reducing number components inactivation methods. We aimed evaluate immunogenicity safety Euvichol-S (EuBiologics, Seoul, South Korea) compared with an active control Shanchol (Sanofi Healthcare India,...
This Technical Report was retired August 2012. For decades, emergency planning for natural disasters, public health emergencies, workplace accidents, and other calamities has been the responsibility of government agencies on all levels certain nongovernment organizations such as American Red Cross. In case terrorism, however, entirely new approaches to are under development a variety reasons. Terrorism preparedness is highly specific component general preparedness. addition unique pediatric...
BackgroundA single-dose regimen of inactivated whole-cell oral cholera vaccine (OCV) is attractive because it reduces logistical challenges for vaccination and could enable more people to be vaccinated. Previously, we reported the efficacy a single dose an OCV during 6 months following dosing. Herein, report results 2 years follow-up.MethodsIn this placebo-controlled, double-blind trial done in Dhaka, Bangladesh, individuals aged 1 year or older with no history receipt were randomly assigned...
Typhoid fever remains a major public health problem in low- and middle-income countries where children aged 2–14 years bear the greatest burden. Vi polysaccharide is poorly immunogenic <2 of age, protection adults modest. The limitations vaccines can be overcome by conjugation to carrier protein. A typhoid conjugate vaccine composed conjugated diphtheria toxoid (Vi-DT) has been developed. Phase I study results are presented here. This was randomized, observer-blinded assess safety...
High mobility group box 1 (HMGB1) protein functions in regulation of transcription, cellular activation and pro-inflammatory responses. However, the potential role HMGB1 during viral infection has not been investigated. This study attempted to elucidate whether HMGB1-mediated inflammatory response contributes pathogenesis dengue virus (DENV) infection. Our data showed that was released at low DENV levels (m.o.i. 1) under non-necrotic conditions by human dendritic cells (DCs). When...
Background: Cholera rapid diagnostic tests (RDTs) can strengthen existing surveillance systems by offering a cost-effective screening method that improves understanding of cholera burden allowing for targeted prevention and control efforts. The RDT Implementation Strategy Evaluation (RISE) project is the pilot study innovative Gavi Diagnostic Procurement Platform which provides RDTs to enhance national surveillance. Methods: was evaluated following their distribution in 2023 facilities...
Cholera rapid diagnostic tests (RDTs) can strengthen existing surveillance systems by offering a cost-effective screening method that improves understanding of cholera burden allowing for targeted prevention and control efforts. The RDT Implementation Strategy Evaluation (RISE) project is the pilot study Gavi’s innovative Diagnostic Procurement Platform which provides RDTs to enhance national surveillance. was evaluated following their distribution in 2023 facilities within Nepal’s Early...
Domestic terrorism is a real threat focusing on need to engage in effective emergency preparedness planning and training. Front-line physicians are an important component of any plan. Potential victims attack include children who have unique physiologic psychological vulnerabilities disasters. providers adequate training effectively participate local initiatives recognize treat casualties including children. The goal the survey was assess current state training, child victims, by medicine,...
This study reveals diverse-length polymorphisms in long mononucleotide repeats (microsatellites) several serotypes of epidemic human respiratory adenovirus. The length one these microsatellites, a homopolymeric thymidine [poly(T)] repeat, is measured 68 isolates adenovirus serotype 14. These were collected during series sudden and sometimes fatal outbreaks among both military recruits civilians as the virus emerged for first time United States 2006 2007. results demonstrate usefulness...
Hepatitis E virus (HEV) is a major cause of acute jaundice worldwide, with case fatality risk (CFR) as high 30% among symptomatic pregnant women.Human HEV includes four genotypes; the nonepidemic, zoonotic genotypes (typically 3 and 4) have gained increasing recognition in North America Europe over past decade [1] because potential transmission through food, blood transfusions, organ donation.However, relatively little attention few resources been invested into 1 2 (g1/g2), which outbreaks...
Typhoid fever remains an important public health problem in developing countries and is endemic many parts of Asia Africa where the incidence disease typically peaks school-aged children. Age restrictions other limitations existing oral live-attenuated typhoid parenteral Vi polysaccharide vaccines have triggered development conjugate with improved immunological properties, use younger age range, longer durability protection. We present safety, reactogenicity, immunogenicity data from a Phase...