A5051570885- Cardiac Ischemia and Reperfusion
- Vagus Nerve Stimulation Research
- Eating Disorders and Behaviors
- Thermal Regulation in Medicine
- Mechanical Circulatory Support Devices
- Immune Response and Inflammation
- Cardiac Arrest and Resuscitation
- Ultrasound and Hyperthermia Applications
- Organ Transplantation Techniques and Outcomes
- Heart Rate Variability and Autonomic Control
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Autism Spectrum Disorder Research
- Child and Adolescent Psychosocial and Emotional Development
- Anesthesia and Neurotoxicity Research
- Family and Disability Support Research
- Hemodynamic Monitoring and Therapy
- Minimally Invasive Surgical Techniques
- Transplantation: Methods and Outcomes
- Gender Roles and Identity Studies
- Pulmonary Hypertension Research and Treatments
- Hydrogen's biological and therapeutic effects
- Cardiac Fibrosis and Remodeling
- ECG Monitoring and Analysis
- Enhanced Recovery After Surgery
- Surgical Simulation and Training
University of Virginia
2019-2024
University of Virginia Health System
2019-2024
Society of Thoracic Surgeons
2022
Western Michigan University
2021
University of California, Los Angeles
2019-2020
University of Arizona
2019
Duke University
2016
Stanford University
2013-2014
Stanford Medicine
2013-2014
VA Palo Alto Health Care System
2013
Recent studies have focused on the contribution of capillary endothelial TRPV4 channels to pulmonary pathologies, including lung edema and injury. However, in hypertension (PH), small arteries are focus pathology, this crucial anatomy remain unexplored PH. Here, we provide evidence that cell caveolae maintain a low arterial pressure under normal conditions. Moreover, activity caveolar is impaired from mouse models PH patients. In PH, up-regulation iNOS NOX1 enzymes at results formation...
Limited data exist on outcomes of older adults receiving psychotherapy for depression in real-world settings. Acceptance and Commitment Therapy (ACT-D) offers potential utility individuals who may experience issues loss, reduced control, other life changes. The present article examines compares younger Veterans ACT-D nationally the U.S. Department Affairs health care system.Patient were assessed using Beck Depression Inventory-Second Edition World Health Organization Quality Life-BREF....
Background We previously demonstrated that ischemically injured cardiomyocytes release cell-free DNA and HMGB1 (high mobility group box 1 protein) into circulation during reperfusion, activating proinflammatory responses ultimately exacerbating reperfusion injury. hypothesize mediate myocardial ischemia-reperfusion injury by stimulating plasmacytoid dendritic cells (pDCs) to secrete type I interferon (IFN-I). Methods Results C57BL/6 alpha receptor-1 knockout mice underwent 40 minutes of left...
An Individualized Mental Health Intervention for ASD, ("AIM HI"), is a collaborative, caregiver-mediated and child-directed intervention reducing challenging behaviors in children with autism spectrum disorder developed delivery community mental health programs. Using observational data from AIM HI sessions, the present study characterized occurrence of two types in-session caregiver behaviors: expressed concerns (i.e., expressing about treatment strategies; difficulty using skills;...
The Saccharomyces cerevisae RAD3 gene is the homolog of human XPD, an essential encoding a DNA helicase TFIIH complex involved in both nucleotide excision repair (NER) and transcription. Some mutant alleles (rad3-101 rad3-102) have partial defects strong hyper-recombination (hyper-Rec) phenotype. Previous studies showed that hyper-Rec phenotype associated with rad3-101 rad3-102 can be explained as consequence persistent single-stranded gaps are converted to recombinogenic double-strand...
BackgroundThe spleen is an important contributor to the uncontrolled, excessive release of proinflammatory signals during sepsis that leads development tissue injury and diffuse end-organ dysfunction. Therapeutic pulsed ultrasound (pUS) has been shown inhibit splenic leukocyte reduce cytokine production in other inflammatory disease processes. We hypothesized pUS treatment inhibits spleen-derived responses increases survival duration rats with severe intra-abdominal leading septic...
Mental health clinicians often report significant challenges when delivering evidence-based interventions in community settings, particularly unexpected client stressors (or emergent life events) interfere with the therapy process. The current study sought to extend of events children autism spectrum disorder by examining occurrence and impact context a collaborative, caregiver-mediated intervention for reducing challenging behaviors disorder, An Individualized Health Intervention ASD (AIM...
Elevated body image concerns may be a risk factor for eating disorders among males and contribute to range of other mental health problems. This study tested 6-item measure general male in two studies with adolescent ages 14–18 (total N = 122). The showed strong convergent validity, scale score reliability, test-retest was significantly correlated the number episodes binge past month. A short will relieve participant burden provide useful research tool at or disorders.
ABSTRACT Objective Heavy episodic drinking (HED) is a serious problem among college women at high‐risk for developing eating disorders (EDs). The main objectives of this study are to determine the relationship self‐rating effects alcohol (SRE) questionnaire and HED over time, breakups on college‐aged EDs. Method Data collected from 163 participants in randomized controlled trial evaluating effectiveness an ED prevention program were used analyses. Measures included SRE, obtained baseline,...
Background Following acute myocardial infarction (MI), irreversible damage to the myocardium can only be reduced by shortening duration between symptom onset and revascularization. While systemic hypothermia has shown promising results in slowing pre-revascularization damage, it is resource intensive not conducive prehospital initiation. We hypothesized that topical neck cooling (NC), an easily implemented therapy for en route transfer definitive therapy, could similarly attenuate...
We hypothesized that hydroxychloroquine (HCQ) attenuates myocardial ischemia/reperfusion injury (IRI) via TLR9 - type I interferon (IFN-I) pathway inhibition.The left coronary artery of wild-type (WT) C57BL/6 and congenic TLR9-/- mice was occluded for 40 minutes, with or without 60 minutes reperfusion (40'/0' 40'/60'). Either ODN-2088 HCQ (TLR9 inhibitors), ODN-1826 agonist) administered to determine effect on infarct size (IS). After 40'/0', cardiac perfusate (CP) collected from harvested...
Abstract Current burn therapy is largely supportive with limited therapies to curb secondary progression. Adenosine 2A receptor (A2AR) agonists have anti-inflammatory effects decreased inflammatory cell infiltrate and release of proinflammatory mediators. Using a porcine comb model, we examined whether A2AR could mitigate Eight full-thickness burns (four prongs three spaces per comb) pig were generated the following specifications: temperature 115°C, 3-kg force, 30-second application time....