A5051335787- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Congenital Heart Disease Studies
- Venous Thromboembolism Diagnosis and Management
- Liver Disease Diagnosis and Treatment
- Cardiovascular Issues in Pregnancy
- Cardiovascular Disease and Adiposity
- Transplantation: Methods and Outcomes
- Ultrasound in Clinical Applications
- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Heart Failure Treatment and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Non-Invasive Vital Sign Monitoring
- Magnesium in Health and Disease
- Tracheal and airway disorders
- Liver Disease and Transplantation
- Trauma Management and Diagnosis
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Renal and Vascular Pathologies
- Healthcare Decision-Making and Restraints
- Brucella: diagnosis, epidemiology, treatment
- Vascular Anomalies and Treatments
- Diagnosis and Treatment of Venous Diseases
University of Virginia
2015-2023
University of Virginia Medical Center
2020-2022
Stanford University
2022
Stanford Medicine
2022
University of Virginia Health System
2016-2021
National Heart Lung and Blood Institute
2016
Lovelace Respiratory Research Institute
2016
National Institutes of Health
2016
RIKEN Center for Integrative Medical Sciences
2016
RIKEN
2016
Genetic defects in telomere maintenance and repair cause bone marrow failure, liver cirrhosis, pulmonary fibrosis, they increase susceptibility to cancer. Historically, androgens have been useful as treatment for failure syndromes. In tissue culture animal models, sex hormones regulate expression of the telomerase gene.In a phase 1-2 prospective study involving patients with diseases, we administered synthetic hormone danazol orally at dose 800 mg per day total 24 months. The goal was...
Recent studies have focused on the contribution of capillary endothelial TRPV4 channels to pulmonary pathologies, including lung edema and injury. However, in hypertension (PH), small arteries are focus pathology, this crucial anatomy remain unexplored PH. Here, we provide evidence that cell caveolae maintain a low arterial pressure under normal conditions. Moreover, activity caveolar is impaired from mouse models PH patients. In PH, up-regulation iNOS NOX1 enzymes at results formation...
Abstract Background Acute pulmonary embolism remains a significant cause of mortality and morbidity worldwide. Benefit recently developed multidisciplinary PE response teams (PERT) with higher utilization advanced therapies has not been established. Methods To evaluate patient-centered outcomes cost-effectiveness PERT we performed retrospective analysis 554 patients acute at the university Virginia between July 2014 June 2015 (pre-PERT era) April 2017 through October 2018 (PERT era)....
Administrative claims studies do not adequately distinguish pulmonary arterial hypertension (PAH) from other forms of (PH). Our aim is to develop and validate a set algorithms using International Classification Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes electronic medical records (EMR), identify patients with PAH. From January 2012 August 2015, the EMRs ICD-9-CM for PH an outpatient visit at University Texas Medical Branch were reviewed. Patients divided into PAH or...
Patients with autoimmune lymphoproliferative syndrome (ALPS), a disorder of impaired lymphocyte apoptosis, often undergo radiographic chest imaging to evaluate the presence and progression lymphadenopathy. These images lead parenchymal interstitial lung findings unclear clinical significance.
Background Pulmonary hypertension (PH) is characterized by increased pulmonary vascular resistance leading to right heart failure. Elevated atrial (RA) pressure reflects ventricular (RV) overload and an established risk factor for mortality in PH. We hypothesized that PH patients with ratio of RA LA volume index (RAVI/LAVI), would have mortality. Methods evaluated the association RAVI/LAVI 124 seen at a single academic center's clinic after adjusting REVEAL score, score indices were measured...
ABSTRACT Catecholamine-resistant postoperative vasoplegic syndrome (PVS) lacks effective treatment modalities. Synthetic angiotensin II was recently approved for the of vasodilatory shock; however, its use in PVS is not well described. We report outcomes six patients receiving isolated PVS. All achieved their MAP goal and majority showed improvement lactate background catecholamine dose; variables perfusion changed discordantly. Three survived to hospital discharge.
Background This study evaluated the utility of a novel index, pulmonary arterial (PA) proportional pulse pressure (PAPP; range 0–1, defined as [PA systolic – PA diastolic pressure] / pressure), in predicting mortality patients with World Health Organization group 1 hypertension (PH). Hypothesis Low PAPP is associated increased 5‐year independent validated contemporary risk‐prediction equation (Pulmonary Hypertension Connection [PHC] equation). Methods In 262 National Institutes Primary...
Tracheal intubation leading to injury of the airway is a rare complication transesophageal echocardiography (TEE). trauma not described TEE, and safety literature for this procedure remains silent on matter. We describe case patient systemic anticoagulation antiplatelet therapy who underwent TEE suffered massive hemoptysis requiring bronchial artery embolization (BAE). An elderly was admitted hospital with recently diagnosed atrial fibrillation shortness breath. The successful synchronized...
Pulmonary hypertension (PH) is prevalent in those with end-stage kidney disease (ESKD) and poses a barrier to transplant due its association poor outcomes. Studies examining these adverse outcomes are limited often utilize echocardiographic measurements of pulmonary artery systolic pressure (PASP) instead the gold standard right heart catheterization (RHC). We hypothesized that ESKD patients deemed ineligible for because an diagnosis PH predominant cause hypervolemia potentially...