A5047749036- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Retinal Imaging and Analysis
- Cardiovascular Health and Risk Factors
- Intracranial Aneurysms: Treatment and Complications
- Folate and B Vitamins Research
- Neurological Disease Mechanisms and Treatments
- Gaze Tracking and Assistive Technology
- Traumatic Brain Injury and Neurovascular Disturbances
- Vestibular and auditory disorders
- Trauma and Emergency Care Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Glaucoma and retinal disorders
- Spinal Fractures and Fixation Techniques
- Neurological Disorders and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Healthcare Systems and Practices
- Adipose Tissue and Metabolism
- Neuroscience of respiration and sleep
- Facial Nerve Paralysis Treatment and Research
- Genetic Associations and Epidemiology
- Musculoskeletal pain and rehabilitation
- Workplace Health and Well-being
- EEG and Brain-Computer Interfaces
- Health, Environment, Cognitive Aging
University of Virginia
2019-2025
University of Virginia Health System
2022-2025
University of Maryland, Baltimore
2023-2024
Yale University
2024
University of California, Los Angeles
2024
Wake Forest University
2023
North Carolina Division of Public Health
2023
East Carolina University
2023
University of Virginia Medical Center
2018-2022
American Physical Therapy Association
2020-2021
Seizures are common in dementia and associated with accelerated cognitive decline. However, the impact of active vs remote seizures on cognition remains understudied. This study aimed to investigate people normal mild impairment (MCI).
BACKGROUND: Genetic association studies can reveal biology and treatment targets but have received limited attention for stroke recovery. STRONG (Stroke, Stress, Rehabilitation, Genetics) was a prospective, longitudinal (1-year), genetic study in adults with at 28 US centers. The primary aim to examine the that candidate variants (1) motor/functional outcomes (2) stress-related outcomes. METHODS: For end points, 3 gene (ApoE ε4, BDNF [brain-derived neurotrophic factor], dopamine polygenic...
Purpose: Research has shown that prolonged endotracheal intubation can increase risk of aspiration following extubation. This study examined the relationship between swallowing and among patients with COVID-19. We investigated association duration time until an oral diet was safely initiated correlation length reduced sensation as seen on flexible endoscopic evaluation (FEES)/videofluoroscopic (VFSS). Method: is a retrospective analysis all intubated admitted primary diagnosis COVID-19 April...
Background: Stroke is a major cause of long-term disability and has widely varying recovery outcomes. While clinical factors like stroke severity play role, genetic are increasingly recognized as important contributors to recovery. This study aims identify variants associated with phenotypes through genome-wide association studies (GWAS) protein-protein interaction (PPI) networks. Methods: DNA from STRONG participants was genotyped using the Infinium Global Screening Array, resulting in 565...
Introduction: Despite evidence showing overall improvement of post-stroke outcomes following endovascular therapy (EVT), existing literature on comparative recovery rates different stroke deficits is limited. We hypothesized that the rate change in aphasia may vary compared to other neurological patients post successful EVT. Methods: performed a retrospective analysis acute at single comprehensive center who presented with and underwent EVT from 2022 2023 (n=122). Total itemized NIHSS scores...
Introduction: While adiposity is an established risk factor for incident ischemic stroke, its influence on functional recovery after stroke uncertain. We leveraged Mendelian randomization (MR) to examine the causal effects of body mass index (BMI) and waist-to-hip ratio (WHR) post-stroke motor, cognitive, global recovery. Materials methods: Genetic proxies BMI WHR were obtained from a genome-wide association study (GWAS) meta-analysis GIANT consortium UK Biobank ( n = 806,834). The primary...
Abstract Introduction Sleep is essential for neuronal, metabolic and vascular health. Insomnia increases stroke risk through development of hypertension, diabetes mellitus hyperlipidemia. Stroke causes insomnia by altering sleep architecture. Insomniacs had a 54% with prevalence 2.71% over 4 years in the community. About 50% patients have only 7% undergo appropriate evaluation. Methods To evaluate Transient Ischemic Attack (TIA) insomniacs differences evaluation those cerebrovascular events,...
Genome-wide association studies (GWAS) have advanced our understanding of the polygenic basis complex human diseases. Although translating GWAS findings into clinical application remains difficult, risk scores (PRS) offer a potential approach. PRS methods aim to improve prediction, with Bayesian approaches like PRS-CS and functional-based such as SBayesRC. This study compares these two for incident ischemic stroke (IS) in Black White participants from Reasons Geographic Racial Differences...
Background and Purpose— Clinical trials in spontaneous intracerebral hemorrhage (ICH) have used volume cutoffs as inclusion criteria to select populations which the effects of interventions are likely be greatest. However, optimal for predicting poor outcome deep locations (thalamus versus basal ganglia) unknown. Methods— We conducted a 2-phase study determine ICH (modified Rankin Scale score 4–6) thalamus ganglia. Cutoffs with sensitivity specificity were identified ERICH ([Ethnic/Racial...
Automated eye-tracking technology could enhance diagnosis for many neurological diseases, including stroke. Current literature focuses on gaze estimation through a form of calibration. However, patients with neuro-ocular abnormalities may have difficulty completing calibration procedure due to inattention or other deficits.We investigated 1) the need measure eye movement symmetry in healthy controls and 2) potential distinguish between patients.We analyzed fixations, smooth pursuits,...
Despite notable advances in genetic understanding of stroke recovery, most studies focus only on candidate genes. To date, 2 genome-wide association (GWAS) have focused outcomes, but they were limited to the modified Rankin Scale (mRS). The mRS maps poorly biological processes. Therefore, we performed a GWAS discover single nucleotide polymorphisms (SNPs) associated with motor recovery poststroke.
Stroke genetic research has made substantial progress in the past decade. Its recovery application, however, remains behind, part due to its reliance on modified Rankin Scale (mRS) score as a measure of poststroke outcome. The mRS does not map well biological processes because numerous psychosocial factors drive much what captures. Second, contains multiple disparate events into single further limiting use for discovery. This led us investigate effect distinct stroke phenotypes variation...
Objective: Facial weakness is a common sign of neurological diseases such as Bell's palsy and stroke. However, recognizing facial still remains challenge, because it requires experience training. Methods: We propose framework for detection, which models the temporal dynamics both shape appearance-based features each target frame through bi-directional long short-term memory network (Bi-LSTM). The system evaluated on "in-the-wild"video dataset that verified by three board-certified...
Abstract Objectives Like the concept of work ability in occupational health, gait speed is a measure general fitness and can predict functional decline morbidity. This especially important when our care-takers, i.e. nurses, show become care-receivers. The study aims to describe demographics hospital nurses context as well determine association between them. Methods Three-hundred twelve inpatient nursing assistants were sampled from level 1 trauma teaching several service lines acuity levels....
<title>Abstract</title> Posterior circulation stroke (PCS) presents significant diagnostic challenges due to poorly localizing and non-specific symptoms, such as dizziness, nausea, headache, which are often misattributed benign conditions. This study introduces an innovative tool that utilizes a machine learning algorithm-driven eye tracker enhance early diagnosis of PCS. Our approach involves analyzing movements during three standard neurological examinations: the Dot Test, H Optokinetic...
The ability to perform quantitative and automated neurological assessment could enhance diagnosis treatment in the pre-hospital setting, such as during telemedicine or emergency medical services (EMS) encounters. Such a tool be developed by adapting clinically significant information symmetry of eye movement conjugate movement. Here we describe digital camera-based tracking method "NeuroGaze" capture while performing examination. proposed was based on detecting center pupil for both eyes...
Current EMS stroke screening tools facilitate early detection and triage, but the tools' accuracy reliability are limited highly variable. An automated tool could improve outcomes by facilitating more accurate prehospital diagnosis delivery. We hypothesize that a machine learning algorithm using video analysis can detect common signs of stroke. As proof-of-concept study, we trained computer to presence laterality facial weakness in publically available videos with comparable accuracy,...