A5002860147- Diet and metabolism studies
- Fatty Acid Research and Health
- Renin-Angiotensin System Studies
- Ultrasound and Hyperthermia Applications
- Birth, Development, and Health
- Sodium Intake and Health
- Vagus Nerve Stimulation Research
- Hormonal Regulation and Hypertension
- Nutritional Studies and Diet
- Heart Rate Variability and Autonomic Control
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Aquaculture Nutrition and Growth
- Bone health and osteoporosis research
- Diet, Metabolism, and Disease
- Gut microbiota and health
- Chronic Kidney Disease and Diabetes
- Muscle metabolism and nutrition
- Protein Hydrolysis and Bioactive Peptides
- Cardiovascular Disease and Adiposity
- Liver Disease Diagnosis and Treatment
- Acute Kidney Injury Research
- Renal function and acid-base balance
- Meat and Animal Product Quality
- Bone Metabolism and Diseases
Liberty University
2017-2024
University of Virginia
2013-2016
Immunité et Cancer
2013-2015
University of Virginia Health System
2014
West Virginia University
2007-2013
West Virginia University Hospitals
2010
Long Island University
2008
AKI affects both quality of life and health care costs is an independent risk factor for mortality. At present, there are few effective treatment options AKI. Here, we describe a nonpharmacologic, noninvasive, ultrasound-based method to prevent renal ischemia-reperfusion injury in mice, which model human We exposed anesthetized mice ultrasound protocol 24 hours before ischemia. After reperfusion, ultrasound-treated exhibited preserved kidney morphology function compared with sham-treated...
We showed previously that prior exposure to a modified ultrasound regimen prevents kidney ischemia-reperfusion injury (IRI) likely via the splenic cholinergic anti-inflammatory pathway (CAP) and α7 nicotinic acetylcholine receptors (α7nAChR). However, it is unclear how stimulates CAP. Further investigating role of spleen in ischemic injury, we found splenectomy (-7d) or chemical sympathectomy with 6-hydroxydopamine (6OHDA; -14d) exacerbated after subthreshold (24-minute ischemia) IRI....
Numerous health benefits associated with increased omega-3 polyunsaturated fatty acid (n-3 PUFA) consumption has lead to an increasing variety of available n-3 PUFA sources. However, sources differ in the type, amount, and structural form PUFAs. Therefore, objective this study was determine effect different ω-3 PUFAs on digestibility, tissue deposition, eicosanoid metabolism, oxidative stability. Female Sprague-Dawley rats (age 28 d) were randomly assigned (n = 10/group) be fed a high fat...
The plasticity of dendritic cells (DCs) permits phenotypic modulation ex vivo by gene expression or pharmacologic agents, and these modified DCs can exert therapeutic immunosuppressive effects in through direct interactions with T cells, either inducing regulatory (T(REG)s) causing anergy. Sphingosine 1-phosphate (S1P) is a sphingolipid the natural ligand for five G protein-coupled receptors (S1P1, S1P2, S1P3, S1P4, S1P5), S1PR agonists reduce kidney ischemia-reperfusion injury (IRI) mice....
Caloric sweetened beverages have been suggested to be a major dietary contributor weight gain, particularly among adolescents. Dietary recommendations are for moderating intakes of added sugars; however, the question remains whether certain types sugars should limited. The objective this study was determine effect drinking different caloric on development adiposity, metabolic, and endocrine disorders. Young (age 28 days) female Sprague-Dawley rats (n = 8-9 rats/group) were randomly assigned...
Cardiovascular disease has had an unquestioned status of the number one cause death in US since 1921. Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) have cardio-protective benefits. However, egg is typically a poor source ω-3 PUFAs and, general, American diet low these acids. Novel, nutritionally enhanced products were developed by substituting yolk with PUFA-rich flaxseed, menhaden, algae, or krill oil. Experimental matched composition hen (whole egg). The experimental products, mixed...
Significance Statement GSTM1 encodes a member of superfamily antioxidant enzymes, and highly prevalent deletion variant is associated with kidney disease progression in two human study cohorts. In this study, the authors demonstrate that Gstm1 knockout mice exhibit increased oxidative stress, injury, inflammation models CKD hypertension, loss parenchyma but not bone marrow–derived cells drives renal inflammation. Importantly, consumption broccoli powder or cruciferous vegetables was...
The deleterious bone effects of mechanical unloading have been suggested to be due oxidative stress and (or) inflammation. Resveratrol has both antioxidant anti-inflammatory properties; therefore, the study's objective was determine whether providing resveratrol in low supplementation range for a short duration prevents loss during unloading. Mature (6 months old) Fischer 344 × Brown Norway male rats were hindlimb-suspended (HLS) or kept ambulatory 14 days. Rats provided either...
Extracellular vesicles (EVs) are novel mediators of cell-to-cell communication and appear to mediate the pathogenesis hypertension (HTN). However, mechanisms underlying involvement EVs in HTN remain unclear. The adaptive innate immune systems play an important role affecting kidney vasculature animal models HTN. Evolving evidence shows that cell-derived can modulate system a paracrine fashion therefore may effects inflammation Therefore, we aimed understand if specific subtypes...
Krill protein concentrate (KPC) consists of high-quality (77.7% dry basis) and lipids (8.1% that are rich (27% total fatty acids) in omega-3 polyunsaturated acids (ω-3 PUFAs). The objective the study was to determine digestibility, tissue deposition, metabolism, oxidative stability ω-3 PUFAs provided by KPC. Young female Sprague−Dawley rats (n = 10/group) were fed ad libitum isocaloric diets for 4 weeks with either 10% freeze-dried KPC or casein. casein diet contained 5.3% added corn oil...
Collectrin, encoded by the Tmem27 gene, is a transmembrane glycoprotein with approximately 50% homology angiotensin converting enzyme 2, but without catalytic domain. Collectrin most abundantly expressed in kidney proximal tubule and collecting duct epithelia, where it has an important role amino acid transport. also endothelial cells throughout vasculature, regulates L-arginine uptake. We previously reported that global deletion of collectrin leads to dysfunction, augmented salt...
Congenital obstructive nephropathy is a major cause of chronic kidney disease (CKD) in children. The contribution changes the identity renal cells to pathology poorly understood. Using partial unilateral ureteral obstruction (pUUO) model genetically modified neonatal mice, we traced fate derived from stroma, cap mesenchyme, ureteric bud (UB) epithelium, and podocytes using Foxd1Cre, Six2Cre, HoxB7Cre, Podocyte.Cre mice respectively, crossed with double fluorescent reporter...
The general population is encouraged to increase omega-3 polyunsaturated fatty acid (n-3 PUFA) intake in order optimize health for preventative care. Consumers are typically unaware that different amounts, types, and structural forms of n-3 PUFA have efficacy. Therefore, the objectives this study were characterize sources PUFAs determine whether consumption these oils influences renal composition health. Lipid classes profile corn (CO), flaxseed (FO), menhaden (MO), salmon (SO), tuna (TO) or...
The findings of our study are significant in several ways: 1) loss an amino acid chaperone the proximal tubule is sufficient to cause hypertension, 2) results global and tubule-specific collectrin knockout mice support notion that vascular dysfunction required for salt sensitivity or impaired renal function causes hypertension but not sensitivity, 3) first implicate a role human hypertension.