A5053547178- Mycotoxins in Agriculture and Food
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- RNA modifications and cancer
- Pharmacogenetics and Drug Metabolism
- Carcinogens and Genotoxicity Assessment
- Bacteriophages and microbial interactions
- Endoplasmic Reticulum Stress and Disease
- Fungal and yeast genetics research
- Bacillus and Francisella bacterial research
- Genomics, phytochemicals, and oxidative stress
- Advanced biosensing and bioanalysis techniques
- Probiotics and Fermented Foods
- Peroxisome Proliferator-Activated Receptors
- Cancer-related molecular mechanisms research
- RNA regulation and disease
- Computational Drug Discovery Methods
- Drug Transport and Resistance Mechanisms
- Plant and fungal interactions
- Clostridium difficile and Clostridium perfringens research
- Molecular Biology Techniques and Applications
- Gut microbiota and health
- Veterinary medicine and infectious diseases
- Tuberculosis Research and Epidemiology
- Gene expression and cancer classification
South China Agricultural University
2016-2025
Ministry of Agriculture and Rural Affairs
2018-2023
Key Laboratory of Guangdong Province
2023
University of Birmingham
2008-2017
In-Q-Tel
2016
Chinese Academy of Sciences
2004-2008
Wuhan Institute of Virology
2003-2007
State Key Laboratory of Biomacromolecules
2006
Research Center for Eco-Environmental Sciences
2006
Institute of Biophysics
2006
Abstract Background Studies in developed countries have reported that the prevalence of asthma and rhinitis is higher urban areas than rural areas, this phenomenon associated with urbanization changing indoor microbiome exposure. Developing such as China experienced rapid past years, but no study has investigated exposure urban-rural health effects these countries. Methods Nine high schools from were randomly selected Shanxi Province, China, classroom vacuum dust was collected for shotgun...
Unique spectral properties of quantum dots (QDs) enable ultrasensitive and long-term biolabeling. Aiming to trace the infection, movement, localization viruses in living cells, QD-containing virus-like particles (VLPs) simian virus 40 (SV40), termed SVLP-QDs, are constructed by vitro self-assembly major capsid protein SV40. SVLP-QDs show homogeneity size ( approximately 24 nm), similarity unencapsidated QDs, considerable stability. When incubated with shown enter cells caveolar endocytosis,...
Cytochrome P450 1A1 (CYP1A1) is abundant in the kidney, liver, and intestine involved phase I metabolism of numerous endogenous exogenous compounds. Therefore, exploring regulatory mechanism its basal expression humans particularly important to understand bioactivation several procarcinogens their carcinogenic derivatives. Site‐specific mutagenesis deletion transcription factor binding site determined core cis ‐acting elements human CYP1A1 proximal distal promoter regions. The region...
The production of high yields recombinant proteins is an enduring bottleneck in the post-genomic sciences that has yet to be addressed a truly rational manner. Typically eukaryotic protein experiments have relied on varying expression construct cassettes such as promoters and tags, or culture process parameters pH, temperature aeration enhance yields. These approaches require repeated rounds trial-and-error optimization cannot provide mechanistic insight into biology production. We published...
Deoxynivalenol (DON) is a highly abundant mycotoxin that exerts many adverse effects on humans and animals. Much effort has been made to control DON in the past, bio-transformation emerged as most promising method. However, useful effective application of bacterial for purpose inhibiting remains urgently needed. The current study isolated novel detoxifying bacterium, Slackia sp. D-G6 (D-G6), from chicken intestines. Gram-positive, non-sporulating which ranges size 0.2–0.4 μm × 0.6–1.0 μm....
Deoxynivalenol (DON) is a prevalent mycotoxin that primarily contaminates cereal crops and animal feed, posing significant risk to human health. In recent years, an increasing number of Devosia strains have been identified as DON degradation bacteria, efforts made explore their potential applications in the food feed industries. However, characteristics mechanisms are still unclear. this study, we novel degrading bacterium, sp. D-G15 (D-G15), from soil samples. The major products were...
Background/Objectives: The integration of microbiome and metabolome data could unveil profound insights into biological processes. However, widely used multi-omic analyses often employ a stepwise mining approach, failing to harness the full potential datasets leading reduced detection accuracy. Synergistic analysis incorporating microbiome/metabolome are essential for deeper understanding. Method: This study introduces Coupled Matrix Tensor Factorization (CMTF) framework joint data,...
In eukaryotes the 40S and 60S ribosomal subunits are assembled in nucleolus, but there appear to be mechanisms preventing mRNA binding, 80S formation, initiation of translation nucleus. To visualize association between subunits, we tagged pairs Drosophila proteins (RPs) located different with mutually complementing halves fluorescent proteins. Pairs RPs expected interact, or adjacent structure, showed strong fluorescence, while that were not close proximity did not. Moreover, complementation...
Abstract Deoxynivalenol (DON) is one of the most abundant mycotoxins and exerts many adverse effects on humans animals. To date, transporting mechanism DON in mammalian cells remains unclear. In this study, parallel artificial membrane permeability assay (PAMPA), Transwell models metabolic inhibitors were used to determine possible mechanisms Caco-2, MDCK HepG2 cells. PAMPA showed reduced passive transport increased intestinal absorption, indicating a carrier-mediated mechanism. Furthermore,...
Most ribosomal proteins (RPs) are stoichiometrically incorporated into subunits and play essential roles in ribosome biogenesis function. However, a number of RPs appear to have non-ribosomal functions, which involve direct association with pre-mRNA transcription factors at sites. The consensus is that the found these sites off subunits, but observation different usually together suggests or ribosomal-like might be present. Notably, it has previously been reported antibodies against 20 stain...