A5103113166- Organ Transplantation Techniques and Outcomes
- Liver physiology and pathology
- Immune Response and Inflammation
- Liver Disease Diagnosis and Treatment
- Antibiotic Resistance in Bacteria
- Hepatitis C virus research
- Traditional Chinese Medicine Analysis
- Pancreatic function and diabetes
- Liver Disease and Transplantation
- Cancer-related molecular mechanisms research
- Flavonoids in Medical Research
- Animal Virus Infections Studies
- Gut microbiota and health
- Hepatocellular Carcinoma Treatment and Prognosis
- Phytochemistry and biological activity of medicinal plants
- Cancer Research and Treatments
- Medicinal Plant Pharmacodynamics Research
- Escherichia coli research studies
- Hepatitis B Virus Studies
- Angiogenesis and VEGF in Cancer
- Chemokine receptors and signaling
- Pharmaceutical and Antibiotic Environmental Impacts
- Vibrio bacteria research studies
- Cancer, Stress, Anesthesia, and Immune Response
- Inflammatory mediators and NSAID effects
Southern University of Science and Technology
2023-2024
Jinan University
2023-2024
Northwest A&F University
2009-2023
Zhoukou Normal University
2020
Agriculture and Forestry University
2010-2019
Jilin Agricultural University
2018
Albert Einstein College of Medicine
2006-2014
Montefiore Medical Center
2010-2014
Xuchang University
2011
Air Force Medical University
2001
Oval cells appear and expand in the liver when hepatocyte proliferation is compromised. Many different markers have been attributed to these cells, but their nature still remains obscure. This study a detailed gene expression analysis aimed at revealing identity repopulating vivo capacity. were activated 2-acetylaminofluorene–treated rats subjected partial hepatectomy or d-galactosamine–treated rats. Two surface [epithelial cell adhesion molecule (EpCAM) thymus antigen 1 (Thy-1)] used for...
Sepsis-evoked acute lung injury (ALI) and its extreme manifestation, respiratory distress syndrome (ARDS), constitute a major cause of mortality in intensive care units. High levels the long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) have been positively correlated with increased severity unfavorable prognoses patients sepsis. Nevertheless, function molecular mechanism NEAT1 ALI remain elusive. In current study, high were confirmed lipopolysaccharide- (LPS-) induced mice...
Abstract Background Triclosan [5-chloro-2-(2,4-dichlorophenoxy) phenol, TCS], a common antimicrobial additive in many personal care and health products, is frequently detected human blood urine. Therefore, it has been considered an emerging potentially toxic pollutant recent years. Long-term exposure to TCS suggested exert endocrine disruption effects, promote liver fibrogenesis tumorigenesis. This study was aimed at clarifying the underlying cellular molecular mechanisms of hepatotoxicity...
Hepatocyte function and regeneration are severely compromised in severe liver disease, a common sequela is cirrhosis. Structural changes caused by cirrhosis create cellular environment conducive to the formation of ductular reactions (DRs). Ductular primarily composed oval cells also known as "intermediate hepatobiliary cells". We have conducted single, double, triple staining study lineages present DRs. Staining with NCAM, CK19, HepPar1 has revealed distinctly bipolar structure DRs that...
Engraftment of donor hepatocytes is a critical step that determines the success hepatocyte transplantation. Rapid and efficient integration cells would enable prompt liver repopulation these in response to selective proliferative stimuli offered by preparative regimen. We have earlier demonstrated hepatic irradiation (HIR) combination with variety hepatotrophic growth signals, such as partial hepatectomy factor, can be used regimen for transplanted hepatocytes. In this study, we investigated...
Baicalein (BAI), one of the main components Scutellaria baicalensis Georgi, possesses numerous pharmacological properties, including anti-cancer, anti-oxidative, anti-virus and anti-bacterial activities. The purpose this study was to evaluate hepatoprotective effect baicalein against acetaminophen (APAP)-exposed liver injury in mice, elucidate underlying mechanism. pretreatment significantly alleviated elevation IL-6, IL-1β TNF-α serum hepatic a dose-dependent manner. It also...
Objectives: The aim of the present study was to explore prevalence and molecular characterization extended-spectrum β-lactamase (ESBL)-producing Escherichia coli collected from pig farms in Northwest China. Methods: Between May 2015 June 2017, a total 456 E. isolates were fecal samples healthy diarrheal pigs China screen ESBL producers. β-lactamases, plasmid-mediated quinolone resistance (PMQR) genes virulence among producers corroborated by PCR sequencing. Finally, further grouped according...
Metastatic dormancy often refers to the stable cell cycle arrest of disseminated tumor cells (DTCs) at distant sites. However, whether circulating (CTCs) in blood microenvironment can enter a dormant state prior extravasation and becoming DTCs remains unclear. Using patient-derived melanoma CTC lines animal explant models (CDX), we identified previously unrecognized role cytoskeletal regulator cortactin (encoded by CTTN) controlling mTOR/p53-dependent senescence metastatic dormancy....
Extended-spectrum β-lactamases (ESBLs)-producing Escherichia coli (E. coli) isolates in environment water become progressively a potential threat to public health, while the detailed information about ESBL-producing E. rivers and lakes Northwest China is scarce. In present study, it was aimed characterize isolated from surface waters China. A total of 2686 were obtained eleven screen for ESBL producers. Seventy-six (2.8%) classified as producers, phylogenic groups D accounted 59.2% CTX-Ms...
PEDV, a highly infectious enteric coronavirus, has spread rapidly worldwide and caused severe economic losses. During virus infection, the host regulates innate immunity to inhibit infection.
As one of the most common bacterial pathogens causing nosocomial infections, Pseudomonas aeruginosa is highly adaptable to survive under various conditions. Here, we profiled abundance dynamics 3489 proteins across different growth stages in P. reference strain PAO1 using data-independent acquisition-based quantitative proteomics. The differentially expressed during planktonic exhibit several distinct patterns expression profiles and are relevant biological processes, highlighting continuous...
Background and Aims Preparative hepatic irradiation (HIR), together with mitotic stimulation of hepatocytes, permits extensive repopulation by transplanted hepatocytes in rats mice. However, whole liver HIR is associated radiation-induced disease (RILD), which limits its potential therapeutic application. In clinical experience, restricting to a fraction the reduces susceptibility RILD. Here we test hypothesis that selected lobes regional should be sufficient correct some inherited metabolic...
Surgery and targeted therapy are of equal importance for colorectal cancer (CRC) treatment. However, complete CRC tumor resection remains challenging, new agents also needed efficient Cadherin 17 (CDH17) is a membrane protein that highly expressed in and, therefore, an ideal target imaging-guided surgery therapeutics. This study utilizes CDH17 nanobody (E8-Nb) with the near-infrared (NIR) fluorescent dye IRDye800CW to construct NIR-II probe, E8-Nb-IR800CW, Pseudomonas exotoxin (PE)-based...
Classical swine fever virus (CSFV) is one of the most important viral pathogens leading worldwide threats to pig industry. MicroRNAs (miRNAs) play roles in regulating replication, but whether miRNAs affect CSFV infection still poorly understood. In previous study, we identified four that were down-regulated by umbilical vein endothelial cells (SUVEC). this miR-140, potently genes was investigated. We found miRNA expression significantly inhibited infection. Subsequent studies revealed...
Hepatocyte transplantation (HT) is being explored as a substitute for liver the treatment of diseases. For clinical application HT, preparative regimen that allows preferential proliferation transplanted cells in host and noninvasive method to monitor donor cell engraftment, proliferation, immune rejection would be useful. We describe an imaging employs creatine kinase (CK) gene marker hepatocytes. Creatine unique among genes, because it normally expressed brain muscle tissues therefore not...
We recently reported the isolation and characterization of a novel population progenitor cells called liver-derived (LDPCs), which could differentiate into functional hepatocytes in vitro. However, our original studies resulted relatively low variable hepatic differentiation efficiency without validation vivo potential LDPCs. Here, we report an efficient robust LDPCs under well-defined culture conditions to mature hepatocytes. In addition morphological studies, performed...
Abstract The porcine parvovirus (PPV) VP2 protein was expressed in an insect-baculovirus cell system and purified using Ni-NTA affinity column chromatography. recombinant 6-His-tagged with molecular mass (Mr) of about 64 kDa detected by anti-his antibody anti-PPV serum. Electron microscopy showed that the assembled into spherical particles diameters ranging from 20 to 22 nm. antigenically similar native capsid according HA a Western blotting assay performed polyclonal antibodies collected...
Porcine epidemic diarrhea virus (PEDV) infection causes severe diarrhea, dehydration, and high mortality in sick pigs, causing huge economic losses to the pig industry. However, relationship between cell communication network factor 1 (CCN1) PEDV has not been reported. In this study, we showed that expression of CCN1 was enhanced by infection, observed promotes CREB AP-1 activation promote expression. The PKA p38 inhibitors significantly suppress expression, indicating PEDV-induced may be...
Radiation-induced liver damage (RILD) is a poorly understood and potentially devastating complication of hepatic radiation therapy (RT) for cancers. Previous work has demonstrated that hepatocyte transplantation (HT) can ameliorate RILD in rats. We hypothesized RT inhibits generation cellular ATP suppresses regeneration. To study the metabolic changes occur with without HT, (31)P MRSI data were acquired rats treated partial hepatectomy (PH) alone, PH irradiation (PHRT) or PHRT HT (PHRT+HT)....