A5042216819- Endometrial and Cervical Cancer Treatments
- Endometriosis Research and Treatment
- Ovarian cancer diagnosis and treatment
- Reproductive System and Pregnancy
- Estrogen and related hormone effects
- Cancer, Lipids, and Metabolism
- Uterine Myomas and Treatments
- RNA Research and Splicing
- MRI in cancer diagnosis
- Cancer, Hypoxia, and Metabolism
- Gynecological conditions and treatments
- Cervical Cancer and HPV Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Metabolism, Diabetes, and Cancer
- Cancer Risks and Factors
- Lung Cancer Research Studies
- Cancer-related molecular mechanisms research
- Hernia repair and management
- Effects and risks of endocrine disrupting chemicals
- Sarcoma Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Aquaculture disease management and microbiota
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
Obstetrics and Gynecology Hospital of Fudan University
2020-2025
Central South University
2024
Changsha Medical University
2024
Zhejiang University
2021
Charité - Universitätsmedizin Berlin
2015-2020
University of Iowa Hospitals and Clinics
2018-2020
Fudan University
2019
Humboldt-Universität zu Berlin
2019
Freie Universität Berlin
2019
University of Oxford
2017-2018
To assess the efficacy of metformin in megestrol acetate (MA)-based fertility-sparing treatment for patients with atypical endometrial hyperplasia (AEH) and endometrioid cancer (EEC).A randomised, single-centre, open-label, controlled trial conducted between October 2013 December 2017.Shanghai OBGYN Hospital Fudan University, China.A total 150 (18-45 years old) primary AEH or well-differentiated EEC were randomised into an MA group (n = 74) plus 76).Patients firstly stratified, then to...
Objectives: Although patients with grade I and II endometrioid endometrial adenocarcinoma (EEA) are considered good prognosis, among them 15%-25% died in 5 years.It is still unknown whether integrating estrogen receptor (ER) progesterone (PR) into clinical risk stratification can help select high-risk I-II EEA.This study was to investigate the prognostic value of ER PR double negativity (ER/ loss) EEA, association between ER/PR loss The Cancer Genome Atlas (TCGA) classification.Methods: were...
To evaluate the impact of depth cervical stromal invasion (CSI) on prognosis International Federation Gynecology and Obstetrics (FIGO) stage II endometrioid endometrial cancer (EEC). Patients with FIGO EEC confirmed by postoperative histopathology consecutively admitted to Hospital Fudan University Shanghai Cancer Center between 2008 2017 were included in this study reviewed retrospectively. Two hundred ninety-seven patients study. There 253 (253/297, 85.2%)patients superficial (<50%) 44...
This study investigated the characteristics of progestin-insensitive endometrioid endometrial cancer (EEC) and atypical hyperplasia (AEH) patients receiving fertility-sparing treatments assessed therapeutic effects second-line fertility-preserving treatments.Three hundred thirty-eight with EEC (n=75) or AEH (n=263) treatment were retrospectively analyzed. 'Progestin-insensitive' was defined as meeting one following criteria: 1) presented progressed disease at any time during conservative...
Patients with epithelial ovarian cancer (EOC) are at high risk of tumor recurrence. Human epididymis protein 4 (HE4) has been shown to be overexpressed in EOC. The primary aim our study was evaluate the role HE4 predicting recurrence EOC patients. Furthermore, we assessed after second-line chemotherapy. We retrospectively analyzed data 92 out 275 patients multicenter project "Ovarian Cancer: Diagnosis a silent killer" (OVCAD). concentrations and CA125 were determined preoperatively 6 months...
Sentinel lymph node (SLN) mapping has been recommended as an alternative staging approach to lymphadenectomy for apparent uterine-confined endometrial cancer (EC). However, the prognostic value of SLN alone instead systematic on EC patients remains unclear.A multi-center, open label, non-inferiority randomized controlled trial designed identify if is not inferior pelvic prognosis with intermediate-high-risk clinically confined uterus. Eligible will be 1:1 randomly assigned accept or...
Bisphenol A (BPA) is a widely used plasticizer known to cause various disorders. Despite global reduction in the use of BPA-containing products, prenatal exposure low-dose BPA, even those below established safety limits, has been linked neurological and behavioral deficits childhood. The precise mechanisms underlying these effects remain unclear. In present study, we observed significant increase number cortical neurons offspring born dams exposed BPA during pregnancy. We also found that...
To evaluate the effect of levonorgestrel-releasing intrauterine system (LNG-IUS) plus oral megestrol acetate (MA) as fertility-preserving treatment in patients with early-stage endometrial cancer (EEC).In this single-center, phase II study open-label, randomized and controlled design, young (18-45 years) diagnosed primary EEC were screened, who strongly required treatment. Patients randomly assigned (1:1) into MA group (160 mg daily) or LNG-IUS group. Pathologic evaluation on endometrium...
// Yuqin Zhang 1, * , Tingyan Shi Sheng Yin 1 Sining Ma Di Jun Guan 2, 3 Libing Xiang 4 Yang Liu Yulan Ren Deyan Tan 5 and Rongyu Zang Division of Gynecologic Oncology, Department Obstetrics Gynecology, Zhongshan Hospital, Fudan University, Shanghai, China 2 Tumor Bank Ovarian Cancer, European Competence Center for Campus Virchow Clinic, Charité Medical University Berlin, Germany Nuffield Oxford, United Kingdom Cancer Center, Anatomy, Shanghai College, These authors contributed...
About 10-66% of patients with atypical endometrial hyperplasia diagnosed before surgery (preoperative-AEH) are found to have concurrent cancer (EC) at definitive hysterectomy, leading incomplete primary and delayed adjuvant treatment. This study aims investigate the potential risk factors EC in preoperative-AEH a clinical setting gynecological pathology review. All AEH by biopsy or curettage that then underwent hysterectomy from January 2016 December 2019 tertiary hospital were...
<title>Abstract</title> <bold>Objective: </bold>This study aimed to investigate if childhood body mass index (BMI) causally contributed the risk of endometrial cancer (EC), which had not been well answered. <bold>Methods: </bold>Genetic instruments were selected using single-nucleotide polymorphisms (SNPs) associated with BMI in European population from a large-scale genome-wide association studies (GWAS, n= 39,620). A two-sample Mendelian randomization (MR) was performed evaluate effect...
To assess the long-term efficacy of metformin in megestrol acetate (MA)-based fertility-sparing treatment for patients with endometrial atypical hyperplasia (EAH) and endometrioid cancer (EEC).
<title>Abstract</title> Background The incidence of endometrial cancer (EC)is constantly rising, but its mortality has not been improved in decades. Understanding the molecular mechanism EC may improve early diagnosis and develop more targeted therapies. Mitochondrial dysfunction currently reported to impact pathogenesis various cancers. Thus, this study investigated whether mitochondrial proteins contributed development EC. Methods Using meta-analyses data from genome-wide association...
This study aimed to explore the potential effects between various human plasma lipidomes and endometrioid endometrial cancer (EEC) by using Mendelian randomization (MR) methods.
<h3>Objectives</h3> The clinical remission (CR) rate of Megestrol acetate (MA) as fertility-sparing treatment was still not optimal. This study to access whether MA plus metformin could lead better CR for patients with atypical endometrial hyperplasia (AEH) and well-differentiated cancer (EC). <h3>Methods</h3> a randomized, single-center, open-label controlled trial (July 2013-December 2017). Patients were randomized receive (160mg, orally, daily) or (500mg, three times day), then underwent...
Abstract Objective Morular metaplasia (MM) is a benign epithelial that sometimes appears in atypical endometrial hyperplasia (AEH) and endometrioid carcinoma (EEC). However, the clinical implications of MM for fertility-preserving treatment AEH EEC patients are unclear. This study investigated features impact on efficacy treatment. Methods We retrospectively studied 427 who received Clinical features, efficacy, onco-fertility results were compared between with without MM. Results appeared...
<h3>Introduction/Background</h3> Almost 30% of patients diagnosed with atypical endometrial hyperplasia before surgery (preoperative-AEH) are found to have concurrent cancer (EC) at definitive hysterectomy, leading incomplete primary and delayed adjuvant treatment. This study aimed investigate whether preoperative level human epididymis protein 4 (HE4) could predict EC for preoperative-AEH help establish a nomogram better clinical management. <h3>Methodology</h3> Preoperative-AEH who...
<h3>Introduction</h3> This study aimed to investigate whether preoperative human epididymis protein 4 (HE4) could predict concurrent endometrial cancer (EC) for patients diagnosed with atypical hyperplasia before surgery and help establish a nomogram better clinical management. <h3>Methods</h3> Preoperative-AEH who underwent hysterectomy in tertiary hospital from Jan 2020 Dec 2022 were retrospectively analyzed. Independent predictive factors determined by multivariate logistic regression...