Citation Wang B, Koga K, Osuga Y, Hirata T, Saito A, Yoshino O, Hirota Harada M, Takemura Fujii Taketani Y. High mobility group Box 1 (HMGB1) levels in the placenta and serum preeclampsia. Am J Reprod Immunol 2011; 66: 143–148 Problem Preeclampsia is a pregnancy disorder characterized by systemic inflammation. box molecule known to act as ‘danger signal’ participating various inflammatory processes, but data regard preeclampsia are sparse. The aim of this study was analyze placental HMGB1...

Quality control in disease diagnosis and treatment is critical for ensuring patient safety, optimizing resource utilization, improving clinical outcomes. In endometrial cancer management, rigorous quality ensures accurate through standardized protocols, reducing misdiagnosis enabling early detection. Treatment guided by evidence-based guidelines, fostering multidisciplinary collaboration minimizing unnecessary variations care. also enhances safety medical errors compliance with ethical legal...

Sentinel lymph node (SLN) mapping has been recommended as an alternative staging approach to lymphadenectomy for apparent uterine-confined endometrial cancer (EC). However, the prognostic value of SLN alone instead systematic on EC patients remains unclear.A multi-center, open label, non-inferiority randomized controlled trial designed identify if is not inferior pelvic prognosis with intermediate-high-risk clinically confined uterus. Eligible will be 1:1 randomly assigned accept or...

To explore the diagnostic value of integrated positron emission tomography/magnetic resonance imaging (PET/MRI) for staging endometrial carcinoma and to investigate associations between quantitative parameters derived from PET/MRI clinicopathological characteristics carcinoma. Altogether, 57 patients with who underwent PET/computed tomography (PET/CT) preoperatively were included. Diagnostic performance PET/CT was compared by three readers. Associations primary tumor lesions analyzed....

The aim of this retrospective study is to analyze the clinical and pathological factors related prognosis Chinese patients with stage Ib IIb cervical cancer.13 in 255 cancer undergoing radical hysterectomy systematic lymphadenectomy were analyzed screen for prognosis. cumulative 5-year survival was 75.7%. result univariate analysis suggested that stage, cell differentiation, depth stromal invasion, parametrial tissue involvement, lymph node metastasis prognostic (P<0.05). Compared cases...

The molecular classification of endometrial cancer has previously been shown to be associated with clinical outcomes. However, there are insufficient data support the routine use for treatment patients seeking fertility preservation.Here, we retrospectively investigated 90 received fertility-sparing treatment. We used a next generation sequencing (NGS) panel classify these into four subtypes. All hormonal therapy combined hysteroscopy. Therapeutic effects were evaluated by hysteroscopy every...

The remarkable advancements in large language models (LLMs) and large-scale visual encoders have laid a solid foundation for enhancing the capabilities of artificial intelligence (AI) various application scenarios. In this study, we introduce MOSS-MED, suite designed biomedical vision-language understandings. MOSS-MED includes two currently: MOSS-MED-2.5B MOSS-MED-LLaMA, with different scale their underlying LLMs. We employ two-stage training pipeline that involves visual-text alignment...

Abstract Rudimentary uterine horn is an uncommon abnormality of the female reproductive tract. Torsion rudimentary in pregnancy even rarer. A case successful excision distorted second trimester, which caused severe abdominal pain, described. congenital absence right kidney was discovered simultaneously. The continued uneventfully until term delivery.

Objective The aim was to explore the factors associated with parametrial involvement (PI) in patients stage IB IIA cervical cancer. Materials and Methods Medical records of 507 were reviewed. Nine analyzed by univariate analysis using χ 2 test multivariate logistic regression screen for PI. Results There 46 Result suggested depth stromal invasion, lymphovascular space invasion (LVSI), lymph node metastasis, uterine PI ( P &lt; 0.05 all). model included that could be diagnosed a cone biopsy,...

Abstract Background and Objectives Sentinel lymph node (SLN) mapping was considered for treating endometrial cancer (EC) which apparent confined to the uterus. Nevertheless, intermediate‐high‐risk EC patients have super high risk undergo isolated para‐aortic metastases comparing with low‐risk patients. Therefore, this investigation aimed compare efficacy of two SLN methods in detecting metastases. Methods According injection methods, who received both systematic lymphadenectomy were divided...

To assess risk of fetal growth restriction (FGR) by combined screening in early and mid-pregnancy.Pregnant women who received prenatal examinations delivered our hospital from January 2015 to 2019 were selected retrospectively analyzed. All completed two ultrasonographic during pregnancy, i.e. Down's pregnancy (11-13 + 6 weeks) color Doppler mid-pregnancy (20-24 weeks). A total 33 FGR cases screened out, there 1,507 normal pregnant women. The clinical, serological indices recorded. When the...

It has been proven that biomarkers play a key role in the individualized treatment of lung cancer. Correlations between expressions TUBB3/STMN1 and gene mutations epidermal growth factor receptor (EGFR), Kirsten rat sarcoma viral oncogene homolog (KRAS), v-raf murine B (BRAF), phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) non-small cell cancer (NSCLC) would be investigated this may provide essential significance on prognosis predictions drug efficiency.This study total enrolled 46...

Objective: To determine preoperative serum CA125, CA19-9, CA72-4, CEA, and AFP with prognostic value, to establish a risk score based on levels for predicting the overall survival (OS) progression-free (PFS) of endometrial cancer (EC) patients. Methods: A retrospective cohort study 2081 EC patients was conducted at Shengjing Hospital China Medical University. Patient baseline information, tumor characteristics, data five biomarkers (CA125, AFP) were collected. Hazard ratios (HRs) 95%...

Purpose: Non-response to platinum-based neoadjuvant chemotherapy (non-rNACT) reduces the surgical outcomes of patients with locally advanced cervical cancer (LACC). The development an accurate preoperative method predict a patient’s response NACT (rNACT) could help surgeons manage therapeutic intervention in more appropriate manner. Patients and Methods: We recruited total 341 consecutive who underwent followed by radical surgery (RS) at Hubei Cancer Hospital between January 1, 2010 April...

Sentinel lymph node (SLN) mapping and biopsy is a promising technique for visualizing evaluating status in cancer. This approach has been recommended low-risk endometrial cancer (EC) patients by authoritative international guidelines, but it not performed broadly China worldwide. work aims to describe detailed SLN procedures promote the clinical application. postoperative pathologic ultrastaging were conducted patient with EC using indocyanine green (ICG) dye track SLNs under laparoscopy...

By using the Medical Case Inquiry System and registries of infant's birth,the number women with gestational diabetes mellitus(GDM)and total delivering in First Second Affiliated Hospital Chongqing University,Chongqing Xinqiao Hospital,and Health Center For Women Children from 2005 to 2009 were obtained.The data 540 pregnant GDM further analyzed.From 2009,the incidence increased 2.29% 3.81 %(P 0.05).From other related factors,including average maternal age,the constituent ratio advanced...

Objective To investigate the outcomes in patients with pregnancy complicated intracranial tumors who underwent comprehensive management. Methods We retrospectively reviewed clinical data, anesthesia management and outcome of pregnant women tumor admitted to Beijing Tiantan Hospital, Capital Medical University from December 2012 2017 19 cases were enrolled into this study. One case was at first trimester (≤12 weeks), 9 second (13-28 weeks) third (>28 weeks). The operation, newborn for...

Objective: To evaluate the risk of lymph node metastasis and figure out necessity lymphadenectomy in grade 3 endometroid endometrial cancer (EEC) patients. Methods: From 2009 to 2019, 3751 (EC) patients were diagnosed at Gynecology Hospital Fudan University, 1235 EEC enrolled multivariable analysis. 381 had survival analysis attributed sufficient follow-up information. Kaplan-Meier curve logrank test used analyze rate. Results: Among patients, multivariate showed lymph-vascular invasion...