A5044141896- Cancer-related molecular mechanisms research
- Endometrial and Cervical Cancer Treatments
- Circular RNAs in diseases
- Ovarian cancer diagnosis and treatment
- MicroRNA in disease regulation
- RNA modifications and cancer
- RNA Research and Splicing
- Estrogen and related hormone effects
- Reproductive System and Pregnancy
- Cancer, Lipids, and Metabolism
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Ferroptosis and cancer prognosis
- Gynecological conditions and treatments
- Cancer Risks and Factors
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Epigenetics and DNA Methylation
- Ectopic Pregnancy Diagnosis and Management
- Cell death mechanisms and regulation
- Angiogenesis and VEGF in Cancer
- Advanced Glycation End Products research
- Neuroblastoma Research and Treatments
- Histone Deacetylase Inhibitors Research
China Medical University
2016-2025
Shandong University
2025
Educational Department of Liaoning Province
2024
Sheng Jing Hospital
2018
Ningbo University
2013
Zhejiang University
2013
Beijing Center for Disease Prevention and Control
2010
Endometrial cancer (EC) is one of the three major gynecological malignancies. Numerous biomarkers that may be associated with survival and prognosis have been identified through database mining in previous studies. However, predictive ability single-gene not sufficiently specific. Genetic signatures an improved option for prediction. This study aimed to explore data from The Cancer Genome Atlas (TCGA) identify a new genetic signature predicting EC.mRNA expression profiling was performed...
Elucidation of the molecular mechanisms underlying ovarian cancer (OC) cell invasion and migration may provide important evidence for developing efficient therapy. Recently, Matrix metalloproteinase (MMP) has been shown to be regulated by vascular endothelial growth factor family members, especially placental (PLGF), as a potential mechanism invasion. Here, we studied relationship between PLGF MMP7 in OC.We examined levels resected OC specimens compared paired adjacent non-tumor tissue. We...
Abstract Background The preoperative peripheral blood neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte (PLR) and monocyte-lymphocyte (MLR) have been reported to be associated with the prognosis of various cancers but are always discussed separately. aim this study is bring combination NLR, PLR MLR into prognostic assessment system endometrial cancer (EC) establish a nomogram provide an objective prediction model for clinical decisions. Methods A total 1111 patients EC who had accepted...
Long noncoding RNAs (lncRNAs) play important regulatory roles in a variety of pathological processes involving cancer. However, the exact molecular mechanisms lncRNA regulation endometrial carcinoma (EC) remain poorly defined. The aim this study was to illustrate mechanism LINC00958 regulating function IGF2BP3, an RNA binding protein involved mRNA stability, and their clinical implications EC. First, we investigated role IGF2BP3 EC demonstrated its prognostic value. Loss-of-function...
Uterine corpus endometrial carcinoma (UCEC) is frequently diagnosed among women worldwide. However, there are different prognostic outcomes because of heterogeneity. Thus, the aim current study was to identify a gene signature that can predict prognosis patients with UCEC. UCEC expression profiles were first downloaded from The Cancer Genome Atlas (TCGA) database. After data processing and forward screening, 11 390 key genes selected. samples randomly divided into training testing sets. In...
Abstract Endometrial cancer stem cells (ECSCs) play a vital role in endometrial (EC) metastasis, relapse, and chemoresistance. However, the molecular mechanisms that sustain ECSCs remain elusive. Here, we showed expression of UPF1 was upregulated EC tissues correlated with poor clinicopathological characteristics. silencing suppressed ECSC hallmarks, such as sphere formation ability, carboplatin resistance, migration invasion, cell cycle progression. regulated behavior fate by stabilizing...
Effective interventions to promote language competence, cognitive abilities and integrate these skills into daily activities for children with autism spectrum disorder (ASD) often involve providing guidance training through specific tasks, typically delivered by speech therapists directive interactions. However, engaging ASD in such is not straightforward fraught challenges. Yet we know very little about how practitioners cope when the interaction breaks down, example, due misunderstandings...
Abstract Tumor stem cells (TSCs) are thought to contribute the progression and maintenance of cancer. Previous studies have suggested that plasmacytoma variant translocation 1 (PVT1) has a tumor-promoting effect on endometrial cancer; however, its mechanism action in cancer (ECSCs) is unknown. Here, we found PVT1 was highly expressed cancers ECSCs, correlated with poor patient prognosis, promoted malignant behavior stemness (ECCs) ECSCs. In contrast, miR-136, which lowly had opposite effect,...
Abstract Clear cell carcinoma (CCC), endometrioid (EC), and serous (SC) are the major histological subtypes of epithelial ovarian cancer (EOC), whose differences in carcinogenesis still unclear. Here, we undertake comprehensive proteomic profiling 80 CCC, 79 EC, SC, 30 control samples. Our analysis reveals prognostic or diagnostic value dysregulated proteins phosphorylation sites important pathways. Moreover, protein co-expression network not only provides view biological features each...
Cervical cancer is one of the most frequent gynecological malignancies in women worldwide. MicroRNA-195 (miR-195) was recently found highly expressed cervical cancer. However, role miR-195 pathology remains poorly understood. In this study, we first confirmed downregulation primary tissues. For functional introduced sequences or inhibitor into Hela and SiHa cell lines. Overexpression inhibited proliferation both cells. contrast, reducing endogenous level by promoted Flow cytometric assay...
Uterine corpus endometrial carcinoma (UCEC) is the most common type of gynecologic malignancy worldwide. Despite advances in treatments UCEC, its incidence and mortality rates are still increasing. N6-methyladenosine (m6A) form RNA modification has attracted increasing interest cancer pathogenesis progression. Thus, we aimed to identify landscape m6A regulators build a prognostic gene signature UCEC. In this study, first analyzed copy number variations (CNVs), single nucleotide (SNVs)...
The incidence of endometrial cancer is increasing each year, and treatment effects are poor for patients with advanced specific subtypes. Exploring immune infiltration-related factors in can aid the prognosis provide new immunotherapy targets. We downloaded metagene functional data different subtypes from Cancer Genome Atlas database selected lymphocyte-specific kinase (LCK) as a representative genetic marker microenvironment cancer. results showed that LCK expression related to endometrioid...
Inflammatory response is an important feature of most tumors. Local inflammation promotes tumor cell immune evasion and chemotherapeutic drug resistance. We aimed to build a prognostic model for endometrial cancer patients based on inflammatory response-related genes (IRGs). RNA sequencing clinical data uterine corpus were obtained from TCGA datasets. LASSO-penalized Cox regression was used obtain the risk formula model: score = esum(corresponding coefficient à each geneâs expression)....
The deregulation of fatty acid metabolism plays a pivotal role in cancer. Our objective is to construct prognostic model for patients with endometrial carcinoma (EC) based on genes related metabolism-related (FAMGs). RNA sequencing and clinical data EC were obtained from Cancer Genome Atlas (TCGA). Lasso-Penalized Cox regression was employed derive the risk formula model, score = esum(corresponding coefficient × each gene's expression). Gene set enrichment analysis (GSEA) utilized examine...
To investigate the effect of transabdominal hysterectomy on diversity intestinal flora in patients with uterine fibroids. Patients fibroids were selected from September 2018 to December 2018, Department Obstetrics and Gynecology, Shengjing Hospital China Medical University, stool specimens collected before after surgery.High-throughput sequencing 16S rRNA gene was used detect changes microbial community structure diversity, effects total further analyzed. Estrogen levels decreased...