We recruited 805 patients with suspicious pulmonary masses that were identified finally as lung cancer or benign masses. The serum levels of four tumor markers, including squamous cell carcinoma antigen (SCC), carcinoembryonic (CEA), cytokeratin 19 fragment 21-1 (Cyfra21-1) and neuron specific enolase (NSE) tested for every patient. Though receiver operating characteristic (ROC) curves indicated unsatisfactory diagnostic power those markers cancer, 37.3% early-staged could be diagnosed just...

MicroRNAs (miRNAs) have essential roles in carcinogenesis and tumor progression. Here, we investigated the mechanisms of miR-143 non-small cell lung cancer (NSCLC). was significantly decreased NSCLC tissues lines. Overexpression suppressed proliferation, induced apoptosis, inhibited migration invasion vitro. Integrated analysis identified LIM domain kinase 1 (Limk1) as a direct functional target miR-143. Limk1 attenuated suppressive effects cells. Moreover, inversely correlated with...

This study aimed to retrospectively summarize the clinical signs, diagnosis, and treatment of congenital bronchial atresia (CBA) in 12 patients.Chest radiographs computed tomographic (CT) images patients with CBA treated Chinese People's Liberation Army General Hospital were reviewed.Analysis chest revealed ten had hilar mass-like shadows two pneumonia-like shadows; most (n = 8) showed hyperlucency peripheral lung fields.CT a mucocele all 12); mucoceles round four club-like eight.In 80%...

This study aimed to establish a nomogram predict the overall survival (OS) of general non-small-cell lung cancer (NSCLC) patients with distant metastasis.We investigated Surveillance, Epidemiology, and End Results database for NSCLC metastasis diagnosed between 2010 2014. Statistically significant prognostic factors were identified using uni- multivariable Cox regression analyses. A incorporating these was developed evaluated by Harrell's concordance index (C-index), calibration plots, risk...

The aim of this study was to analyze our experience with management intrathoracic anastomotic leak after esophagectomy. Clinical data from 33 patients who developed were evaluated retrospectively. These selected 1867 undergoing resection carcinoma the esophagus and reconstruction between January 2003 December 2012. Surgical intervention reformed "three-tube method" applied in 13 20 patients, respectively. overall incidence leakage 1.8%. median time interval esophagectomy diagnosis 9.7 days....

Solitary fibrous tumor of the pleura (SFTP) represents a clinical entity rarely encountered, especially in giant forms. Complete surgical resection for is challenge. The aim this article to present five new cases SFTP, and discuss their characteristics treatment strategy such neoplasms.We performed retrospective review records patients who underwent surgery huge SFTP (>18 cm diameter) between 2007 2009.Four were symptomatic. All angiography embolization tumor-supplying vessels within 24 h...

Abstract To shed light on the interaction between American Joint Committee Cancer (AJCC) T stage and M in determination of overall survival (OS) cancer-specific (CSS) esophageal carcinoma patients. Moreover, to confirm our hypothesis that tumors metastasize distant sites early may reflect a more biologically aggressive disease compared with those advanced stages. We performed retrospective cohort study patients who were pathologically diagnosed cancer 2004 2014 surveillance epidemiology end...

Inhibitor of differentiation 4 (Id4) plays an important role in tumorigenesis, but its cancer chemoresistance remains unclear. Our study showed that Id4 expression cisplatin-resistant A549/DDP cells was higher than parental A549 cells. Moreover, overexpression results cisplatin resistance and apoptosis inhibition, while increasing the IC50 for through activation phospho-p38 MAPK. However, knockdown shown to resensitize induce apoptosis, as well decrease inactivation In addition, a p38 MAPK...

To study the clinical characteristics, treatment and prognosis of patients with solitary fibrous tumor pleura (SFTP) in order to improve diagnostic accuracy SFTP.A retrospective analysis imaging features, serum biochemical changes, pathological characteristics follow-up results was conducted for 40 SFTP from January 1998 March 2010.A chest CT diagnosis 63.6% patients; unenhanced contrast-enhanced findings were significantly different among cohort (P<0.01). Patients lacking a uniform MRI...

To explore the clinical characteristics, surgical treatment and prognosis of non-small cell lung cancer (NSCLC) among elderly patients over 80 years.The data, methods, perioperative management, postoperative complications 52 NSCLC aged years were retrospectively analyzed.Out cases, 27 had a long-term smoking history (51.9%) 44 with other diseases (84.6%). Lobectomy was done in 32 cases (65.4%), sub-lobectomy 20 (38.5%), including pulmonary wedge resection 16 (30.8%) segment 4 (7.7%). The...

The clinical data of 18 patients with PB from April 1989 to 2013 was analyzed retrospectively, including 11 men and 7 women, aged 45 76 years old (mean 53 years). There were 12 cases occurring in right lung other left lung. Among them, 3 had no symptoms, 15 displayed symptoms cough, chest pain, asthenia or minor haemoptysis. Overall, a preoperative diagnosis cancer, preoperatively diagnosed as the diseases, which included benign tumor (n=5) mediastinal mass (n=2). All received radical...

Gastric cancer is the major cause of cancer-related death worldwide.The aberrant expression PEG10 paternally expressed gene 10 involved in development a range cancers.Although biological function and underling mechanism human gastric carcinoma are still unknown, LncRNA knockdown could present promising therapeutic strategy for treatment cancer.Herein, PEG10, miR-3200 AEG1 NCI-N87 cells was altered by cell transfection assay, viability, migration, invasion, apoptosis were determined trypan...

It has been established that the tumor microenvironment (TME) a crucial role in enabling tumors to evade from host immune responses. Previous studies demonstrated cells are not only able reshape milieu at site, but also exert systemic effects, which be important for metastasis. At present, how peripheral environment change tumor-bearing is unclear. The present study identified number of changes proportions lymphocyte subpopulations and levels cytokines patients with NSCLC, may provide...

Perforation is the most serious complication of esophageal foreign bodies. Studies examining association between diabetes and body-induced perforation are largely non-existent.The purpose this study was to identify risk factors for perforation.A retrospective chart review patients with bodies January 2012-January 2017 performed at Chinese People's Liberation Army General Hospital. The were divided into two groups: those complicated without perforation. Date on patient demographics, symptoms,...