A5059476293- Tracheal and airway disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Congenital Heart Disease Studies
- Cardiac Fibrosis and Remodeling
- Transplantation: Methods and Outcomes
- Congenital Diaphragmatic Hernia Studies
- RNA modifications and cancer
- Aortic Disease and Treatment Approaches
- Cancer-related gene regulation
- Orthopaedic implants and arthroplasty
- Organ Transplantation Techniques and Outcomes
- Neonatal Respiratory Health Research
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Congenital Anomalies and Fetal Surgery
- Epigenetics and DNA Methylation
- HVDC Systems and Fault Protection
- Vascular anomalies and interventions
- Ferroptosis and cancer prognosis
- Genetics and Neurodevelopmental Disorders
- Infective Endocarditis Diagnosis and Management
- Foreign Body Medical Cases
- GDF15 and Related Biomarkers
Anhui Medical University
2010-2025
Second Hospital of Anhui Medical University
2014-2025
First Affiliated Hospital of Anhui Medical University
2023
Anhui Provincial Hospital
2007-2011
Chaohu Hospital of Anhui Medical University
2008
Dysregulated mitochondrial metabolism occurs in several pathological processes characterized by cell proliferation and migration. Nonetheless, the role of fission is not well appreciated cardiac fibrosis, which accompanied enhanced fibroblast We investigated causes consequences fibrosis using cultured cells, animal models, clinical samples. Increased METTL3 expression caused excessive fission, resulting migration fibroblasts that lead to fibrosis. Knockdown suppressed inhibiting for...
Metals serve as co-factors for a host of metalloenzymes involved in mitochondrial metabolic reprogramming. Modifications metal homeostasis are linked to epigenetic mechanisms. However, the mechanisms through which affects cardiac fibrosis (CF) remain poorly understood. The content mouse heart samples was measured using inductively coupled plasma mass spectrometry. Cardiac fibroblast-specific MeCP2-deficient mice and control were treated with isoprenaline/angiotensin II induce CF. AAV9...
ABSTRACT Dacomitinib is an irreversible inhibitor targeting epidermal growth factor receptor, which has been developed for the treatment of metastatic non‐small cell lung cancer (NSCLC). The aim this study was to establish a reliable liquid chromatography combined with high resolution mass spectrometric method identify and characterize metabolites dacomitinib in rats. In vitro metabolism investigated through 60‐min incubation rat liver microsomes, while vivo analysis involved bile urine...
The surgical management of Ebstein's anomaly represents a major challenge.Thirty consecutive patients with received treatment in the period from April 2002 to October 2009. Operations included annuloplasty, repair tricuspid valve using autologous pericardium and replacement. In most cases, was done instead an annuloplasty anterior leaflet alone. Associated congenital malformations were also repaired during operation. Follow-up ranged 6 82 months.Intraoperative transesophageal...
Background It has been reported that tumor immune microenvironment performs a vital role in progress. However, acting mechanism of cell related genes (IRGs) esophageal squamous carcinoma (ESCC) is uncertain. Methods TCGA-ESCC, GSE23400, GSE26886, GSE75241, and GSE196756 datasets were gained via public databases. First, differentially expressed (DEGs) between ESCC control samples from GSE75241 screened out by differential expression analysis, overlapping DEGs identified. Single-cell...
Background: Valvular heart disease is a significant cause of morbidity and mortality worldwide. Artificial valves are currently the most widely accepted biomedical material. However, material's blood compatibility still not sufficient. Biomaterial with good biocompatibility has yet appeared. Our initial study was to evaluate probable cytotoxicity hydroxyapatite (HA) on human umbilical vein endothelial cells (HUVEC) for mechanical valve prosthesis applications. Methods Results: Cell growth...
Airway stenosis still remains a major complication after lung or heart-lung transplantation, usually as result of anastomotic ischemia. Once it develops, is associated with high morbidity and mortality. The current management ischemic includes endoscopic debridement, manual fulguration laser vaporization, balloon dilatation the stenosis. Among various methods available, self-expandable metallic stents appear to have fewer long-term complications when used for airway following transplantation...
Aortic-left ventricular tunnel is a rare congenital cardiac anomaly, which always arises from the right coronary sinus and enters left ventricle, occasionally ventricle atrium. However, aortic associated with infective endocarditis rarely seen in literatures. Here, we present case of 47-year-old man.
We present the case of a 51 years old female who experienced foreign body aspiration 3 before. The body, which should be removed by bronchoscopy before, was lodged at bifurcation right inferior bronchus and could only via lower lobectomy. patient swift recovery well follow-up 8 months later.