A5060025359- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Immune Cell Function and Interaction
- Lysosomal Storage Disorders Research
- T-cell and B-cell Immunology
- Mosquito-borne diseases and control
- Parasites and Host Interactions
- Calcium signaling and nucleotide metabolism
- Cytomegalovirus and herpesvirus research
National Institute of Biomedical Research
2020-2023
Wellcome Centre for Molecular Parasitology
2020-2023
University of Glasgow
2023
University of Kinshasa
2016-2019
The role of mammalian skin in harbouring and transmitting arthropod-borne protozoan parasites has been overlooked for decades as these pathogens have regarded primarily blood-dwelling organisms. Intriguingly, infections with low or undetected blood are common, particularly the case Human African Trypanosomiasis caused by Trypanosoma brucei gambiense. We hypothesise, therefore, represents an anatomic reservoir infection. Here we definitively show that substantial quantities trypanosomes exist...
Abstract Background The diagnosis of gambiense human African trypanosomiasis (gHAT) typically involves 2 steps: a serological screen, followed by the detection living trypanosome parasites in blood or lymph node aspirate. Live can, however, remain undetected some seropositive individuals, who, we hypothesize, are infected with Trypanosoma brucei their extravascular dermis. Methods To test this hypothesis, conducted prospective observational cohort study gHAT focus Forecariah, Republic...
Human African trypanosomiasis (HAT), or sleeping sickness, is a fatal disease found throughout sub-Saharan Africa. The close to elimination in many areas, although it was similarly once before and subsequently reemerged, despite seemingly low rates of transmission. Determining how these foci persisted overcame an apparent transmission paradox key finally eliminating HAT. By assessing clinical, laboratory, mathematical data, we propose that asymptomatic infections contribute through the...
Abstract African trypanosomes colonise the skin to ensure parasite transmission. However, how responds trypanosome infection remains unresolved. Here, we investigate local immune response of in a murine model using spatial and single cell transcriptomics. We detect expansion dermal IL-17A-producing Vγ6 + cells during infection, which occurs subcutaneous adipose tissue. In silico cell-cell communication analysis suggests that interstitial preadipocytes trigger T activation via Cd40 Tnfsf18...
The meningeal space is a critical brain structure providing immunosurveillance for the central nervous system (CNS), but impact of infections on immune landscape far from being fully understood. extracellular protozoan parasite Trypanosoma brucei, which causes human African trypanosomiasis (HAT) or sleeping sickness, accumulates in spaces, ultimately inducing severe meningitis and resulting death if left untreated. Thus, sickness represents an attractive model to study immunological dynamics...
Abstract The meningeal space is a critical brain structure providing immunosurveillance for the central nervous system, but impact of infections on immune landscape far from being fully understood. extracellular protozoan parasite Trypanosoma brucei , which causes Human African Trypanosomiasis (HAT) or sleeping sickness, accumulates in spaces, ultimately inducing severe meningitis and resulting death if left untreated. Thus, sickness represents an attractive model to study immunological...
Abstract African trypanosome parasites colonise the skin in a process important for parasite transmission. However, how responses to infection remain unresolved. Here, using combination of spatial and single cell transcriptomics, coupled with vivo genetic models, we investigated local immune response murine model infection. First, detected significant expansion IL-17A-producing γδ T cells (primarily Vγ6 + ) infected compared naïve controls that occur mainly subcutaneous adipose tissue....
Abstract Background The diagnosis of Human African Trypanosomiasis (HAT) typically involves two steps: a serological screen, followed by the detection living trypanosome parasites in blood or lymph node aspirate. Live can, however, remain undetected some seropositive individuals, who we hypothesize are infected with Trypanosoma brucei gambiense their extravascular dermis. Methods and findings To test this hypothesis, conducted prospective observational cohort study HAT (gHAT) focus...