A5057729479- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Glycosylation and Glycoproteins Research
- T-cell and Retrovirus Studies
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- NF-κB Signaling Pathways
- Inflammatory mediators and NSAID effects
- Bone Metabolism and Diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Pediatric health and respiratory diseases
- Bone health and treatments
- Virus-based gene therapy research
- Animal Genetics and Reproduction
- Macrophage Migration Inhibitory Factor
- vaccines and immunoinformatics approaches
- Antimicrobial Peptides and Activities
- Microbial Natural Products and Biosynthesis
- Gene expression and cancer classification
- Dermatology and Skin Diseases
- Chemokine receptors and signaling
Ferring Pharmaceuticals (United States)
2023
Eli Lilly (United States)
2020-2022
Tokyo University of Science
2008-2021
Japan Science and Technology Agency
2015-2021
Harvard University
2010-2020
Boston University
2020
Moscow Research and Clinical Center for Neuropsychiatry
2017
The University of Tokyo
2006-2015
Systems Biology Institute
2010-2015
Kyoto University
2010
Early T cells keep autoimmunity at bay A major challenge faced by the immune system is to react foreign substances, such as microbes, while simultaneously tolerating self. Upsetting this balance leads autoimmunity. Regulatory (T regs ), are a subset of that help maintain balance. Yang et al. found murine reg generated very early in life distinct from those older animals and play an especially important role keeping check (see Perspective Tanaka Sakaguchi). These changes due differences way...
It is well known that IL-1 involved in bone resorption under pathological conditions. The role of this cytokine remodeling physiological conditions, however, remains obscure. In study, we addressed the metabolism through analyses IL-1α-deficient (KO), IL-1β KO and IL-1α/β double mice were housed specific pathogen free femur mineral density, trabecular mass cortical thickness significantly increased all compared with wild-type (WT) mice. number osteoclasts bones decreased, suggesting...
Abstract Introduction Chemokines and their receptors are potential therapeutic targets in rheumatoid arthritis (RA). Among these, several studies suggested the involvement of CXC chemokine 4 (CXCR4) its ligand 12 (SDF-1) RA pathogenesis. However, role these molecules T-cell function is not known completely because embryonic lethality Cxcr4- Cxcl12- deficient mice. In this report, we generated T cell-specific Cxcr4 -deficient mice showed that CXCR4 cells important for development...
Abstract Dendritic cell immunoreceptor (DCIR) is a C-type lectin receptor mainly expressed in DCs. Dcir−/− mice spontaneously develop autoimmune enthesitis and ankylosis accompanied by fibrocartilage proliferation ectopic ossification. However, the mechanisms of new bone/cartilage formation remain to be elucidated. In this study, we show that DCIR maintains bone homeostasis regulating IFN-γ production under pathophysiological conditions. deficiency increased volume femurs caused aberrant...
Dendritic cell immunoreceptor (DCIR) is a C-type lectin receptor containing carbohydrate recognition domain in its extracellular portion and an tyrosine–based inhibitory motif, which transduces negative signals into cells, cytoplasmic portion. Previously, we showed that Dcir(–/–) mice spontaneously develop autoimmune diseases such as enthesitis sialadenitis due to excess expansion of dendritic cells (DCs), suggesting DCIR critically important for the homeostasis immune system. In this...
Rheumatoid arthritis (RA) is an autoimmune disease affecting approximately 1% of the population worldwide. Previously, we showed that human T-cell leukemia virus type I-transgenic mice and interleukin-1 receptor antagonist-knockout develop autoimmunity joint-specific inflammation resembles RA. To identify genes involved in pathogenesis arthritis, analyzed gene expression profiles these animal models by using high-density oligonucleotide arrays. We found 1,467 were differentially expressed...
Dendritic cell immunoreceptor (DCIR) is a C-type lectin receptor with carbohydrate recognition domain and an tyrosine-based inhibitory motif. Previously, we showed that Dcir−/− mice spontaneously develop autoimmune enthesitis sialadenitis, also metabolic bone abnormalities. However, the ligands for DCIR functionality remain to be elucidated. Here expressed on osteoclasts DCs binds asialo-biantennary N-glycan(s) (NA2) cells myeloid cells. Osteoclastogenesis was enhanced in cells, NA2...
The ability of the immune system to avoid autoimmune disease relies on tolerization thymocytes self-antigens whose expression and presentation by thymic medullary epithelial cells (mTECs) is controlled predominantly Aire at transcriptional level possibly regulated other unrecognized levels. Aire-sensitive gene influenced several molecular factors, some which belong 3’end processing complex, suggesting they might impact transcript stability levels through an effect 3’UTR shortening. We...
Abstract T-cell-specific Rap1 deletion causes spontaneous colitis in mice. In the present study, we revealed that deficiency T cells impaired preceding induction of intestinal RORγt + Treg cells. large lamina propria (LILP) Rap1-knockout mice (Rap1KO mice), Th17 were found to increase a microbiota-dependent manner, and inhibition IL-17A production prevented development colitis. LILP Rap1KO mice, scarcely induced by 4 weeks age. The expression CTLA-4 on Rap1-deficient was reduced CD80 CD86...
To examine the roles of microRNAs in development colitis, we conducted RNA-sequencing studies using RNA derived from normal and colitogenic CD4+ T cells. Colitogenic CD4
Abstract The ability of the immune system to avoid autoimmune disease relies on tolerization thymocytes self-antigens whose expression and presentation by thymic medullary epithelial cells (mTECs) is controlled predominantly Aire at transcriptional level possibly regulated other unrecognized levels. Aire-sensitive gene influenced several molecular factors, some which belong 3’end processing complex, suggesting they might impact transcript stability levels through an effect 3’UTR shortening....
Rheumatology has pioneered in the study of autoantibodies by showing that they are not only involved pathogenesis but also highly useful as diagnostic biomarkers.The biomarker aspect autoimmunity gained increasing importance cancer and many insights have contributed to understanding significance cancer.Features rheumatic disorders: In diseases no individual autoantibody-antigen system sufficient combination sensitivity specificity serve a biomarker.Instead, several antigen-antibody systems...
Although the rat is extensively used as a laboratory model, inability to utilize germ line-competent embryonic stem (ES) cells has been major drawback for studies that aim elucidate gene functions.Recently, zinc-finger nucleases (ZFNs) were successfully create genome-specific double-stranded breaks and thereby induce targeted mutations in wide variety of organisms including plants, drosophila, zebrafish, etc.Here we report on ZFN-induced targeting interleukin 2 receptor gamma (Il2rg) locus,...