A5023571383- Immune Response and Inflammation
- HIV Research and Treatment
- Inflammatory Bowel Disease
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Gut microbiota and health
- Polysaccharides and Plant Cell Walls
- RNA Interference and Gene Delivery
- Dermatology and Skin Diseases
- Trace Elements in Health
- S100 Proteins and Annexins
- CRISPR and Genetic Engineering
- Seaweed-derived Bioactive Compounds
- MicroRNA in disease regulation
- Bacterial Genetics and Biotechnology
- Immune cells in cancer
- Psoriasis: Treatment and Pathogenesis
- Cancer, Stress, Anesthesia, and Immune Response
- Microscopic Colitis
- Clostridium difficile and Clostridium perfringens research
- Single-cell and spatial transcriptomics
- HIV/AIDS drug development and treatment
- Whipple's Disease and Interleukins
- Helicobacter pylori-related gastroenterology studies
- Antimicrobial Peptides and Activities
Tokyo University of Science
2006-2023
Broad Institute
2020-2023
Harvard University
2017-2023
Massachusetts General Hospital
2020-2023
Massachusetts Institute of Technology
2020
The University of Tokyo
2009-2017
Center for Systems Biology
2017
Systems Biology Institute
2010-2015
Shinshu University
2011
Japan Science and Technology Agency
2011
Dectin-1 (gene Clec7a), a receptor for β-glucans, plays important roles in the host defense against fungi and immune homeostasis of intestine. Although this molecule is also suggested to be involved regulation tumorigenesis, role intestinal tumor development remains elucidated. In study, we find that azoxymethane-dextran-sodium-sulfate-induced ApcMin-induced tumorigenesis are suppressed Clec7a-/- mice independently from commensal microbiota. preferentially expressed on myeloid-derived...
Common genetic variants interact with environmental factors to impact risk of heritable diseases. A notable example this is a single-nucleotide variant in the Solute Carrier Family 39 Member 8 (SLC39A8) gene encoding missense A391T, which associated variety traits ranging from Parkinson's disease and neuropsychiatric cardiovascular metabolic diseases Crohn's disease. The remarkable extent pleiotropy exhibited by SLC39A8 A391T raises key questions regarding how single coding can contribute...
Dectin-1 (gene symbol: Clec7a) is a receptor for β-glucans that play an important role the host defense against fungi. Recently, we showed Clec7a−/− mice are resistant dextran sodium sulfate (DSS)-induced colitis because of regulatory T-cell population expansion in colon. The caused by commensal Lactobacillus murinus whose growth suppressed antimicrobial protein, calprotectin S100A8/A9. In this report, S100A8 was mainly produced mouse colonic epithelial cells. not induced directly but...
Mouse cells do not support human immunodeficiency virus type 1 (HIV-1) replication because of host range barriers at steps including entry, transcription, RNA splicing, polyprotein processing, assembly, and release. The exact mechanisms for the suppression, however, are completely understood. To elucidate further against HIV-1 in mouse cells, we analyzed lymphocytes from CD4/CXCR4 transgenic mice. Although primary splenocytes thymocytes allowed entry reverse transcription HIV-1, integration...
In the course of development acquired immunodeficiency syndrome (AIDS), bacterial infection causes deleterious effects on progression disease; LPS in circulation activate immune cells, resulting acceleration HIV replication. However, precise activation mechanisms infected hosts remain largely unknown. Previously, we generated transgenic (Tg) mice carrying type I (HIV-1) genome and showed that induces HIV-1 splenocytes through induction tumor necrosis factor (TNF) IL-1, although similarly...
Abstract Genome-wide association studies have identified common genetic variants impacting human diseases; however, there are indications that the functional consequences of polymorphisms can be distinct depending on cell type–specific contexts, which produce divergent phenotypic outcomes. Thus, impact variation and underlying mechanisms disease risk modified by effects genotype pathological phenotypes. In this study, we extend these concepts to interrogate interdependence type–...
Attempts to create mouse models for AIDS have been hampered by species barriers in HIV-1 infection. We previously showed that the nuclear accumulation of preintegration complex (PIC) was suppressed cells. Lens epithelium-derived growth factor (LEDGF/p75) is a host identified as binding partner integrase (IN), and has suggested be involved promoting viral integration tethering PIC chromatin, which are observed IN LEDGF/p75. Therefore, we here hypothesized this might act one species-specific...