Joonas Naamanka
A5076116872- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Pharmacogenetics and Drug Metabolism
- Grit, Self-Efficacy, and Motivation
- Psychosocial Factors Impacting Youth
- RNA modifications and cancer
- Child and Adolescent Psychosocial and Emotional Development
- Autism Spectrum Disorder Research
- Resilience and Mental Health
- RNA Research and Splicing
- Personality Disorders and Psychopathology
- Cardiac Valve Diseases and Treatments
- Genetics and Neurodevelopmental Disorders
- BRCA gene mutations in cancer
Heidelberg University
2024
University Hospital Heidelberg
2024
University of Helsinki
2022-2024
Central Institute of Mental Health
2024
Abstract Understanding the genetic architecture of schizophrenia (SCZ) is invaluable for development personalized treatment. In three independent cohorts, using an automated pipeline, we calculated 413 psychiatry-relevant polygenic scores. Using these scores, machine learning was applied to stratify SCZ patients into two biotypes in FinnGen (n =7486), and validate results PsyCourse Study =421) Bari =531). While showed comparable risk, they were primarily distinguished by a greater...
Abstract Major depression (MD) is a common mental disorder and leading cause of disability worldwide. We conducted GWAS meta-analysis more than 1.3 million individuals, including 371,184 with MD, identifying 243 risk loci. Sixty-four loci are novel, glutamate GABA receptors that targets for antidepressant drugs. Several biological pathways components were enriched genetic MD risk, implicating neuronal development function. Intersection functional genomics data prioritized likely causal genes...
Abstract Environmental and genetic risk factors contribute to the development of borderline personality disorder (BPD). We conducted largest GWAS BPD date, meta-analyzing data from 12,339 cases 1,041,717 controls European ancestry, identified six independent associated genomic loci, nine genes in gene-based analysis. observed a single-nucleotide polymorphism (SNP) heritability 17.3% derived polygenic scores (PGS) predicted 4.6% phenotypic variance case-control status. showed strongest...