Tobias Gradinger
A5066923679- Long-Term Effects of COVID-19
- Machine Learning in Healthcare
- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 diagnosis using AI
- COVID-19 Clinical Research Studies
- Chronic Disease Management Strategies
- Biomedical Text Mining and Ontologies
- Pain Mechanisms and Treatments
- Thermal Regulation in Medicine
- Asthma and respiratory diseases
- Cardiac Imaging and Diagnostics
- Respiratory and Cough-Related Research
- Pain Management and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Artificial Intelligence in Healthcare
- Sepsis Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Data-Driven Disease Surveillance
- Personality Disorders and Psychopathology
- Mobile Health and mHealth Applications
- Genomics and Rare Diseases
- COVID-19 and Mental Health
- Clinical Reasoning and Diagnostic Skills
Heidelberg University
2019-2023
University Hospital Heidelberg
2019-2023
Central Institute of Mental Health
2019-2021
Heidelberg University
2020
University Medical Centre Mannheim
2019-2020
University of Mannheim
2019
We leveraged the largely untapped resource of electronic health record data to address critical clinical and epidemiological questions about Coronavirus Disease 2019 (COVID-19). To do this, we formed an international consortium (4CE) 96 hospitals across five countries (www.covidclinical.net). Contributors utilized Informatics for Integrating Biology Bedside (i2b2) or Observational Medical Outcomes Partnership (OMOP) platforms map a common model. The group focused on temporal changes in key...
For some SARS-CoV-2 survivors, recovery from the acute phase of infection has been grueling with lingering effects. Many symptoms characterized as post-acute sequelae COVID-19 (PASC) could have multiple causes or are similarly seen in non-COVID patients. Accurate identification PASC phenotypes will be important to guide future research and help healthcare system focus its efforts resources on adequately controlled age- gender-specific a infection.In this retrospective electronic health...
<h3>Importance</h3> Additional sources of pediatric epidemiological and clinical data are needed to efficiently study COVID-19 in children youth inform infection prevention treatment patients. <h3>Objective</h3> To describe international hospitalization trends key features with COVID-19. <h3>Design, Setting, Participants</h3> This retrospective cohort included patients hospitalized between February 2 October 10, 2020. Patient-level electronic health record (EHR) were collected across 27...
Importance The COVID-19 pandemic has been associated with an increase in mental health diagnoses among adolescents, though the extent of increase, particularly for severe cases requiring hospitalization, not well characterized. Large-scale federated informatics approaches provide ability to efficiently and securely query care data sets assess monitor hospitalization patterns conditions adolescents. Objective To estimate changes proportion hospitalizations adolescents following onset...
Introduction: Data quality (DQ) is an important prerequisite for secondary use of electronic health record (EHR) data in clinical research, particularly with regards to progressing towards a learning system, one the MIRACUM consortium's goals. Following successful integration i2b2 research repository MIRACUM, we present standardized and generic DQ framework.
Characterizing Post-Acute Sequelae of COVID (SARS-CoV-2 Infection), or
ABSTRACT We leveraged the largely untapped resource of electronic health record data to address critical clinical and epidemiological questions about Coronavirus Disease 2019 (COVID-19). To do this, we formed an international consortium (4CE) 96 hospitals across 5 countries ( www.covidclinical.net ). Contributors utilized Informatics for Integrating Biology Bedside (i2b2) or Observational Medical Outcomes Partnership (OMOP) platforms map a common model. The group focused on comorbidities...
Abstract Understanding the genetic architecture of schizophrenia (SCZ) is invaluable for development personalized treatment. In three independent cohorts, using an automated pipeline, we calculated 413 psychiatry-relevant polygenic scores. Using these scores, machine learning was applied to stratify SCZ patients into two biotypes in FinnGen (n =7486), and validate results PsyCourse Study =421) Bari =531). While showed comparable risk, they were primarily distinguished by a greater...
Abstract Neurological complications worsen outcomes in COVID-19. To define the prevalence of neurological conditions among hospitalized patients with a positive SARS-CoV-2 reverse transcription polymerase chain reaction test geographically diverse multinational populations during early pandemic, we used electronic health records (EHR) from 338 participating hospitals across 6 countries and 3 continents (January–September 2020) for cross-sectional analysis. We assessed frequency International...
ABSTRACT Objectives To perform an international comparison of the trajectory laboratory values among hospitalized patients with COVID-19 who develop severe disease and identify optimal timing value collection to predict severity across hospitals regions. Design Retrospective cohort study. Setting The Consortium for Clinical Characterization by EHR (4CE), multi-site data-sharing collaborative 342 in US Europe. Participants Patients COVID-19, admitted before or after PCR-confirmed result...
The Demonstrator study aims to analyse comorbidities and rare diseases among patients from German university hospitals within the Medical Informatics Initiative. This work aimed design determine feasibility of a model assess quality claims data used in study. Several issues were identified affecting small amounts cases one participating sites. As next step an extension all sites is planned.
Abstract Ventilation heterogeneity is frequent in bronchial asthma and can be assessed using multiple breath wash-out testing (MBW). Most data available paediatric patients nitrogen as a tracer gas. We aimed to evaluate sulphur hexafluoride (SF 6 ) MBW adult asthmatics. Spirometry, whole-body plethysmography, impulse oscillometry SF -MBW were prospectively performed. parameters reflecting global (lung clearance index, LCI), acinar (S acin conductive cond ventilation derived from three...
Abstract This study aimed to investigate whether the differences in pain perception between patients with borderline personality disorder (BPD) and healthy subjects (HCs) can be explained by glutamate/GABA ratio posterior insula. In total, 29 BPD 31 HCs were included statistical analysis. Mechanical sensitivity was experimentally assessed pinprick stimuli 32 512 mN on a numeric rating scale. The metabolites measured right insula using MEshcher–GArwood Point-RESolved Spectroscopy sequence for...
Arterial spin labeling (ASL) is a functional neuroimaging technique that has been frequently used to investigate acute pain states. A major advantage of ASL as opposed blood-oxygen-level-dependent its applicability for low-frequency designs. As such, represents an interesting option studies in which repeating experimental event would reduce ecological validity. Whereas most so far have thermal stimuli, our knowledge, no study investigated responses sharp mechanical pain.As proof concept, we...
<b>Background:</b> Ventilation heterogeneity is frequent in obstructive lung disease and can be assessed using multiple breath washout testing (MBW). In bronchial asthma, most data available pediatric collectives N<sub>2</sub> as tracer gas suffering from several technical issues. We therefore aimed to evaluate the feasibility of MBW sulfur hexafluoride (SF<sub>6</sub>) adult asthmatic patients. <b>Methods:</b> parameters reflecting global (lung clearance index, LCI), acinar...
Hintergrund: Ventilationsinhomogenitäten sind bei Patienten mit obstruktiven Lungenerkrankungen häufig und können mittels multiple breath washout-Verfahren (MBW) beurteilt werden. Bei Asthma bronchiale wurden die meisten Daten in pädiatrischen Kollektiven unter Verwendung von Stickstoff als Tracergas erhoben, was zahlreichen technischen Problemen behaftet ist. Ziel unserer Arbeit war es daher Durchführbarkeit eines auf Schwefelhexafluorid (SF6) basierenden MBW-Systems erwachsenen...