A5048784176- CNS Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immune Cell Function and Interaction
- Viral-associated cancers and disorders
- CAR-T cell therapy research
- T-cell and Retrovirus Studies
- Hematopoietic Stem Cell Transplantation
- Hematological disorders and diagnostics
- Respiratory viral infections research
- Vasculitis and related conditions
- Autoimmune and Inflammatory Disorders Research
- Parasitic infections in humans and animals
- Atomic and Subatomic Physics Research
- vaccines and immunoinformatics approaches
- Hepatocellular Carcinoma Treatment and Prognosis
- Glioma Diagnosis and Treatment
- Nail Diseases and Treatments
- Cancer Immunotherapy and Biomarkers
- Neonatal Respiratory Health Research
- Autoimmune Neurological Disorders and Treatments
- Single-cell and spatial transcriptomics
- Reproductive System and Pregnancy
Charité - Universitätsmedizin Berlin
2014-2025
Humboldt-Universität zu Berlin
2021-2025
Freie Universität Berlin
2021-2024
Recently, a novel classification for pulmonary adenocarcinomas (ADCs) was published, the cornerstone of which is quantification growth patterns. Data on reproducibility in routine diagnostic setting are lacking. 100 constitutive cases lung ADC resection specimens from our archives were classified independently by five pathologists and two residents according to International Association Study Lung Cancer/American Thoracic Society/European Respiratory Society classification. The most frequent...
Abstract Background Ferritin is an established biomarker in the diagnosis of secondary hemophagocytic lymphohistiocytosis (HLH), which diagnosed by HLH‐2004 criteria. Among these criteria, detection hemophagocytosis through invasive procedures may delay early life saving treatment. Our aim was to investigate value diagnosing HLH critically ill patients. Methods In this analysis a retrospective observational study, we included all patients aged ≥18 years and admitted any adult ICU at...
Prognosis and quality of life advanced cutaneous T cell lymphoma (CTCL) patients, in particular those with Sézary syndrome (SS) advanced-stage mycosis fungoides (MF), are poor. Monoclonal antibodies or antibody-drug conjugates (ADCs) have been implemented into CTCL therapy algorithms, but the spectrum antibody-targetable cell-surface antigens on non-Hodgkin lymphomas (T-NHL) is limited. To evaluate expression MHC-II chaperone CD74 across common subtypes by various methods, to explore...
Therapy-related acute myeloid leukemia (t-AML) often exhibits adverse (genetic) features. There is ongoing discussion on the impact of t-AML long-term outcome in AML. Therefore, we retrospectively analyzed clinical and biological characteristics 1133 AML patients (225 908 de novo patients) with a median follow-up 81.8 months. T-AML showed more genetic alterations, higher age comorbidities as compared to Median OS intensively treated was 13.7 months 39.4 (p < 0.001). With non-intensive...
Abstract Purpose In recent years the tumor microenvironment and its interaction with has emerged into research focus increased attention to composition of Tumor-infiltrating lymphocytes. We wanted quantify Regulatory T cells (Tregs) helper 17 (Th17 cells) their prognostic impact in high-grade serous tubo-ovarian carcinoma. Methods Tregs Th17 were determined by immunohistochemical analysis CD25 FoxP3 RORγt, respectively on tissue microarrays a cohort 222 patients reviewed histology available...
Systemic mastocytosis is defined by the clonal proliferation of abnormal mast cells. The clinical course can range from indolent forms with normal life expectancy to advanced cell leukemia dismal prognosis. An association other diseases, including myeloproliferative neoplasia, has been described. We present a case 75-year patient history cutaneous who was diagnosed more than 9 years ago and did not receive treatment. presented our clinic acute kidney failure because renal extramedullary...
In acute myeloid leukemia, there is an ongoing debate on the prognostic value of early bone marrow assessment in patients receiving intensive therapy. this retrospective study, we analyzed impact response 1,008 with newly diagnosed who were treated at our institution chemotherapy followed by consolidation and/or allogeneic hematopoietic stem cell transplantation (HSCT). We found that blast persistence has independent negative overall survival, eventfree survival and relapse-free survival....
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Mucosa-associated lymphoid tissue (MALT) lymphomas are slow-growing B-cell mainly diagnosed in the stomach and termed gastric MALT lymphoma (G-MALT). Despite histological evaluation, immunostaining, additional clonality analysis by fragment analysis, a clear-cut diagnosis is not feasible all cases, especially for clinical follow-up of patients after treatment. We examined clonally rearranged immunoglobulin heavy- light-chain gene sequences 36 genomic DNA samples from six different obtained...
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<b>Human bocavirus (HBoV) has to be considered a life-threatening pathogen in adults with atypical pneumonia. Pulsed high-dose glucocorticoid treatment may beneficial patients suffering from severe pulmonary disease caused by HBoV or other viruses.</b>https://bit.ly/3epiMyO
Introduction: Spontaneous rupture of liver tumors, such as hepatocellular adenoma (HCA) and carcinoma (HCC), is rare, but may be life threatening, unspecific symptoms can misleading.Immediate diagnosis, angiographic intervention surgery needed to stop the bleeding. Case Description:We present a case ruptured HCA, which was addressed by 2-step interventional laparoscopic approach.A female 53-year-old patient admitted hospital with epigastric pain for past 3 days.Acute coronary syndrome...
Topic: 19. Aggressive Non-Hodgkin lymphoma - Clinical Background: Secondary central nervous system (SCNSL) confers a dismal prognosis and treatment advances are constrained by the lack of prospective studies real-world evidence. Aims: To determine patient characteristics, treatments outcomes SCNSL. Methods: Patients with SCNSL all entities were included at first diagnosis from June 2011 to 2022 data, prospectively collected in CNS Lymphoma Registry (SCNSL-R) (NCT05114330). Kaplan Meier...