A5028525443- Respiratory Support and Mechanisms
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Hepatitis B Virus Studies
- Respiratory viral infections research
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Lung Cancer Diagnosis and Treatment
- Long-Term Effects of COVID-19
- GaN-based semiconductor devices and materials
- Cardiac Arrest and Resuscitation
- Pneumonia and Respiratory Infections
- COVID-19 and Mental Health
- Semiconductor materials and devices
- Obstructive Sleep Apnea Research
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Asthma and respiratory diseases
- Animal Virus Infections Studies
- Ga2O3 and related materials
- Family and Patient Care in Intensive Care Units
- Emergency and Acute Care Studies
- Tracheal and airway disorders
- Intensive Care Unit Cognitive Disorders
United Christian Hospital
2010-2024
Chinese University of Hong Kong
2012-2024
The Tavistock and Portman NHS Foundation Trust
2024
University of North Carolina at Chapel Hill
2024
Korea Electric Power Corporation (South Korea)
2022
National Yang Ming Chiao Tung University
1997-2017
Chang Gung Memorial Hospital
1990-2016
National Defense University
2015
Prince of Wales Hospital
2012-2014
Chang Gung University
2006-2012
We investigated the temporal progression of clinical, radiological, and virological changes in a community outbreak severe acute respiratory syndrome (SARS).We followed up 75 patients for 3 weeks managed with standard treatment protocol ribavirin corticosteroids, assessed pattern clinical disease, viral load, risk factors poor outcome, usefulness diagnostic methods.Fever pneumonia initially improved but 64 (85%) developed recurrent fever after mean 8.9 (SD 3.1) days, 55 (73%) had watery...
<b>Background:</b> The clinical response of patients with severe acute respiratory syndrome (SARS) to a combination lopinavir/ritonavir and ribavirin was examined after establishing the in vitro antiviral susceptibility SARS associated coronavirus panel agents. <b>Methods:</b> prototype nucleoside analogues protease inhibitors currently licensed for use studied. Forty one followed 3 weeks were treated ribavirin. progress virological outcomes monitored compared 111 only who served as...
Despite extensive laboratory investigations in patients with respiratory tract infections, no microbiological cause can be identified a significant proportion of patients. In the past 3 years, several novel viruses, including human metapneumovirus, severe acute syndrome (SARS) coronavirus (SARS-CoV), and NL63, were discovered. Here we report discovery another coronavirus, HKU1 (CoV-HKU1), from 71-year-old man pneumonia who had just returned Shenzhen, China. Quantitative reverse...
Objective: Our study examined the stress level and psychological distress of severe acute respiratory syndrome (SARS) survivors 1 year after outbreak. Method: During SARS outbreak in 2003, we used 10-item Perceived Stress Scale (PSS-10) to assess treated 2 major hospitals (non–health care workers, n = 49; health 30). We invited from same 63; 33) complete PSS-10 again 2004. At that time, they were also asked General Health Questionnaire (GHQ-12) measures depression, anxiety, posttraumatic...
Objective: To quantify stress and the psychological impact of severe acute respiratory syndrome (SARS) on high-risk health care workers (HCWs). Method: We evaluated 271 HCWs from SARS units 342 healthy control subjects, using Perceived Stress Scale (PSS) to assess levels a structured list putative effects its effects. Healthy subjects were balanced for age, sex, education, parenthood, living circumstances, lack experience. Results: raised in both groups (PSS = 18) but not relatively...
Abstract On day 22 of illness, generalized tonic-clonic convulsion developed in a 32-year-old woman with severe acute respiratory syndrome (SARS). Cerebrospinal fluid tested positive for SARS coronavirus (SARS-CoV) by reverse transcriptase–polymerase chain reaction. SARS-CoV may have caused an infection the central nervous system this patient.
The authors conducted a study to assess the importance of underlying liver cirihosis in development hepatocellular carcinoma (HCC) and multifactorial etiology cirrhosis chronic carriers hepatitis B virus (HBV). Between November 1980 May 1990, all male surface antigen (HBsAg) who routinely attended clinic for asymptomatic HBV at Liver Unit Chang-Gung Memorial Hospital, Taiwan, were enrolled (n = 1,506). used this cohort investigate prospectively HCC 6-month intervals by means ultrasonography...
Abstract A retrospective viral load study was performed on clinical specimens from154 patients with laboratory-confirmed severe acute respiratory syndrome (SARS), prospectively collected during patients’ illness. Viral in nasopharyngeal aspirates (n = 142) from day 10 to 15 after onset of symptoms associated oxygen desaturation, mechanical ventilation, diarrhea, hepatic dysfunction, and death. Serum 53) Stool 94) urine 111) abnormal urinalysis results. replications at different sites are...
To examine stress and psychological impact in severe acute respiratory syndrome (SARS) patients during the 2003 outbreak. SARS is a novel, highly infectious pneumonia, its still unclear.At peak of outbreak, (n = 79) healthy control subjects 145) completed Perceived Stress Scale (PSS) documented range responses. Groups were balanced for age, sex, education, living circumstances.Stress was significantly higher than subjects. correlated with negative effects. Of patients, 39% 30) infected...
Recently, we described the discovery of a novel group 2 coronavirus, coronavirus HKU1 (CoV-HKU1), from patient with pneumonia. However, clinical and molecular epidemiological features CoV-HKU1-associated pneumonia are unknown.Prospectively collected (during 12-month period) nasopharyngeal aspirates (NPAs) patients community-acquired 4 hospitals were subjected to reverse-transcription polymerase chain reaction, for detection CoV-HKU1. The epidemiological, clinical, laboratory characteristics...
<b>Background:</b> Non-invasive ventilation (NIV) has been shown to reduce intubation and in-hospital mortality in patients with chronic obstructive pulmonary disease (COPD) acute hypercapnic respiratory failure (AHRF). However, little information exists on the outcomes following discharge. A study was undertaken examine rates of readmission, recurrent AHRF, death discharge risk factors associated them. <b>Methods:</b> cohort COPD AHRF who survived after treatment NIV a high dependency unit...
Severe acute respiratory syndrome (SARS) is caused by a novel coronavirus. It may progress to failure, and significant proportion of patients die. Preliminary data suggest that high viral load the SARS coronavirus associated with adverse outcomes in intensive care unit, but relation survival unclear.We prospectively studied an inception cohort 133 virologically confirmed who were admitted 2 general hospitals Hong Kong from Mar. 24 May 4, 2003. The followed until death or for minimum 90 days....
ABSTRACT By using a recombinant severe acute respiratory syndrome coronavirus (SARS-CoV) nucleocapsid protein-based enzyme-linked immunosorbent assay (ELISA) and serum specimens serially collected (from day 0 to 240 after symptom onset) from patients with pneumonia due SARS-CoV, we analyzed the longitudinal profiles of immunoglobulin G (IgG), IgM, IgA antibodies against SARS-CoV protein in SARS-CoV. For IgG, median optical density at 450 nm (OD ) turned positive 17 biphasic response was...
Despite World Health Organization recommendations, the rate of 23-valent pneumococcal (PPV) and influenza (TIV) vaccination among elderly persons in Hong Kong, China, is exceptionally low because doubts about effectiveness vaccination. The efficacy dual remains unknown.From 3 December 2007 to 30 June 2008, we conducted a prospective cohort study by recruiting outpatients aged ≥65 years with chronic illness participate PPV TIV program. All were observed until 31 March 2009. outcome subjects,...
Spontaneous pneumomediastinum (SP) unrelated to assisted ventilation is a newly recognised complication of severe acute respiratory syndrome (SARS). The objective the present study was examine incidence, risk factors and outcomes SP in cohort SARS victims from community outbreak. Data were retrieved prospectively collected database virologically confirmed patients. One hundred twelve cases analysable, with 13 patients developing (11.6%) at mean +/- SD 19.6 4.6 days symptom onset. Peak...
Nocturnal hemodialysis has been shown to improve sleep apnea in patients who receive conventional hemodialysis. It was hypothesized that nocturnal peritoneal dialysis (NPD) also is effective correcting continuous ambulatory PD (CAPD). Overnight polysomnography (PSG) performed 46 stable NPD and CAPD were matched for demographic clinical attributes. The prevalence of apnea, defined as an apnea-hypopnea index (AHI; or frequency hypopnea per hour sleep) ≥15, 52% 91% ( P = 0.007). mean (±SD) AHI...
To examine the role of hepatitis C virus (HCV) infection in spontaneous B surface antigen (HBsAg) clearance during course chronic Bvirus (HBV) infection, serum specimens from 32 asymptomatic HBsAg carriers and 22 patients with type who underwent were studied for antibody to HCV (anti-HCV) using commercial EIAs. The results compared those control groups matched age, sex, e antigen, delta virus, cirrhosis. Eight (25% ) 9 (41%) seropositive anti-HCV contrast 1.6% 9.1% their respective (P <...