A5052579009- Congenital heart defects research
- Hand Gesture Recognition Systems
- Hearing Impairment and Communication
- Subtitles and Audiovisual Media
- Congenital Heart Disease Studies
- Tactile and Sensory Interactions
- Tissue Engineering and Regenerative Medicine
- Cardiac Valve Diseases and Treatments
- Coronary Artery Anomalies
- Human Motion and Animation
- Optical Coatings and Gratings
- Thin-Film Transistor Technologies
- RNA modifications and cancer
- Phase Change Materials Research
- Genetics and Neurodevelopmental Disorders
- Pluripotent Stem Cells Research
- Nanowire Synthesis and Applications
- Surface Roughness and Optical Measurements
- Silicon and Solar Cell Technologies
- Advancements in Photolithography Techniques
- Thermal Expansion and Ionic Conductivity
- Aortic Disease and Treatment Approaches
- Electromagnetic Launch and Propulsion Technology
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
Albert Einstein College of Medicine
2015-2024
Wuhan University of Technology
2017-2024
Shandong University
2024
The Bronx Defenders
2023
Shanghai Clinical Research Center
2023
Shanghai Jiao Tong University
2023
Shanghai First People's Hospital
2023
Changzhou University
2013-2023
Chinese Academy of Sciences
2012-2023
Shanghai Institute of Applied Physics
2022-2023
Congenital anomalies of arterial valves are common birth defects, leading to valvar stenosis. With no pharmaceutical treatment that can prevent the disease progression, prosthetic replacement is only choice treatment, incurring considerable morbidity and mortality. Animal models presenting localized stenosis congenital similar humans critically needed research tools uncover developmental molecular mechanisms underlying this devastating human condition. We generated characterized mouse with...
The dynamic interaction of DNA methylation and transcription factor binding in regulating spatiotemporal gene expression is essential for embryogenesis, but the underlying mechanisms remain understudied. In this study, using mouse models integration vitro vivo genetic epigenetic analyses, we show that REST (repressor element 1 (RE1) silencing factor; also known as NRSF) to its cognate RE1 sequences temporally regulated by non-CpG methylation. This process dependent on methyltransferase 3B...
Abstract Coronary artery anomalies may cause life-threatening cardiac complications; however, developmental mechanisms underpinning coronary formation remain ill-defined. Here we identify an angiogenic cell population for in mice. Regulated by a DLL4/NOTCH1/VEGFA/VEGFR2 signaling axis, these cells generate mature arteries. The NOTCH modulator POFUT1 critically regulates this axis. inactivation disrupts events and results excessive proliferation plexus formation, leading to anomalous...
Despite the importance of cardiomyocyte proliferation in cardiac development and regeneration, mechanisms that promote cell cycle remain incompletely understood. RE1 silencing transcription factor (REST) is a transcriptional repressor neuronal genes. Here we show REST also regulates cycle. binds represses inhibitor gene p21 required for mouse regeneration. Rest deletion de-represses inhibits embryonic or regenerating hearts. By contrast, overexpression cultured cardiomyocytes increases...
Animations of American Sign Language (ASL) and Pidgin Signed English (PSE) have accessibility benefits for many signers with lower levels written language literacy. In prior experimental studies we conducted evaluating animations ASL, native gave informal feedback in which they critiqued the insufficient inaccurate facial expressions virtual human character. While face movements are important conveying grammatical prosodic information ASL signing, no empirical evaluation their impact on...
With the more and frequent short-term peak loads appear in power systems recent years, it is challenging to keep load frequency steady for systems. Demand response launched shave fill valley. Daily regularity of electricity consumption behavior special transformer users are studied this paper. ability evaluation method based on seasonal trend decomposition using locally weighted regression (LOESS) Savitzky–Golay (S–G) filtering algorithms proposed, which can optimize effectiveness demand...
Abstract Developmental etiologies causing complex congenital aortic root abnormalities are unknown. Here we show that deletion of Sox17 in endothelium mice causes underdeveloped leading to a bicuspid valve due the absence non-coronary leaflet and mispositioned left coronary ostium. The respective defects associated with reduced proliferation mesenchyme smooth muscle derived from second heart field cardiomyocytes. Mechanistically, SOX17 occupies Pdgfb transcriptional enhancer promote its...
Motion-capture recordings of sign language are used in research on automatic recognition or generation animations, which have accessibility applications for deaf users with low levels written-language literacy. gloves to record the wearer's handshape. Unfortunately, these require a time-consuming and inexact manual calibration process each time they worn. This paper describes design evaluation new protocol motion-capture gloves, is designed make more efficient be accessible participants who...
Animations of American Sign Language (ASL) have accessibility benefits for many signers with lower levels written language literacy. This paper introduces a novel method modeling and synthesizing ASL animations based on movement data collected from native signers. technique allows the synthesis signs (in particular, inflecting verbs, which are frequent in ASL) whose performance is affected by arrangement locations 3D space that represent entities under discussion. Mathematical models hand...
Silicon nanowire (SiNW) arrays for radial p-n junction solar cells offer potential advantages of light trapping effects and quick charge collection. Nevertheless, lower open circuit voltages (Voc) lead to energy conversion efficiencies. In such cases, the performance depends critically on quality SiNW interfaces. this study, core-shell have been fabricated by growing crystalline silicon (c-Si) nanowires via metal-assisted chemical etching method depositing hydrogenated amorphous (α-Si:H)...
Many researchers internationally are studying how to synthesize computer animations of sign language; such have accessibility benefits for people who deaf and lower literacy in written languages. The field has not yet formed a consensus as best conduct evaluations the quality language animations, this article explores an important methodological issue conducting experimental studies with participants deaf. Traditionally, when evaluating animation, some upper baselines shown comparison during...