<b><i>Objectives:</i></b> To describe the clinical features and coexisting serum autoantibodies in seven patients with encephalitis associated to α-dendrotoxin-sensitive voltage-gated potassium channels (VGKCs), compare this disorder other autoimmune encephalopathies. <b><i>Methods:</i></b> Clinical information was obtained from a retrospective review of medical records telephone interviews. All autoantibody testing performed single laboratory. <b><i>Results:</i></b> The were examined for...

Respiratory failure is a leading cause of postoperative morbidity and mortality in patients undergoing pneumonectomy. The authors hypothesized that intraoperative mechanical ventilation with large tidal volumes (VTs) would be associated increased risk postpneumonectomy respiratory failure.Patients elective pneumonectomy at the authors' institution from January 1999 to 2003 were studied. collected data on demographics, relevant comorbidities, neoadjuvant therapy, pulmonary function tests,...

Objective: We evaluated the effect of two quality improvement interventions (low tidal volume ventilation and restrictive transfusion) on development acute lung injury in mechanically ventilated patients. Design: Observational cohort study. Setting: Three intensive care units a tertiary academic center. Patients: included patients who were for ≥48 hrs excluding those refused research authorization or had preexisting pneumonectomy. Interventions: Multifaceted interdisciplinary intervention...

Abstract We demonstrate that XopD, a type III effector from Xanthomonas campestris pathovar vesicatoria (Xcv), suppresses symptom production during the late stages of infection in susceptible tomato (Solanum lycopersicum) leaves. XopD-dependent delay tissue degeneration correlates with reduced chlorophyll loss, salicylic acid levels, and changes mRNA abundance senescence- defense-associated genes despite high pathogen titers. Subsequent structure-function analyses led to discovery XopD is...

Background Optimal methods of mortality risk stratification in patients the cardiac intensive care unit ( CICU ) remain uncertain. We evaluated ability Sequential Organ Failure Assessment SOFA score to predict a large cohort unselected CICU. Methods and Results Adult admitted from January 1, 2007, December 31, 2015, at single tertiary hospital were retrospectively reviewed. scores calculated daily, Acute Physiology Chronic Health Evaluation APACHE )‐ III ‐ IV on day 1. Discrimination was...

Abstract Editor’s Perspective What We Already Know about This Topic Article Tells Us That Is New Background repeated cross-sectional survey study was conducted to determine the prevalence of, and factors associated with, burnout, distress, depression among anesthesiology residents first-year graduates. hypothesized that heavy workload student debt burden were with a higher risk of physician depression, perception having adequate workplace resources, work–life balance, social support lower...

Information overload in electronic medical records can impede providers' ability to identify important clinical data and may contribute error. An understanding of the information requirements ICU providers will facilitate development systems that prioritize presentation high-value reduce overload. Our objective was determine needs physicians, compared available within an record.Prospective observational study retrospective chart review.Three ICUs (surgical, medical, mixed) at academic...

ABSTRACT Background: The use of norepinephrine may be associated with better outcomes in some patients shock. We sought to determine whether was lower mortality unselected cardiac intensive care unit (CICU) compared other vasopressors, and patterns vasopressor inotrope usage the CICU have changed over time. Methods: retrospectively evaluated consecutive adult admitted a tertiary hospital from January 1, 2007 December 31, 2015. Vasoactive drug doses were quantified using peak...

Background There are no risk scores designed specifically for mortality prediction in unselected cardiac intensive care unit (CICU) patients. We sought to develop a novel CICU-specific score of hospital using variables available at the time CICU admission. Methods and Results A database patients admitted from January 1, 2007 April 30, 2018 was divided into derivation validation cohorts. The top 7 predictors were identified stepwise backward regression, then used Mayo Admission Risk Score...

The implementation of evidence-based practice poses a significant challenge in the intensive care unit. In this quality improvement intervention we assessed effect an institutional protocol and computerized decision support for red cell transfusion critically ill.We compared processes outcomes during two 3-month periods before after introduction multidisciplinary intervention.Multidisciplinary units--medical, surgical, mixed--in tertiary academic center.Consecutive ill patients with anemia...

In 1993, the American Society of Anesthesiologists (ASA) published guidelines stating that automatic perioperative suspension Do Not Resuscitate (DNR) orders conflicts with patients' rights to self-determination. Almost 20 years later, we aimed explore both patient and doctor views concerning DNR status. Five-hundred consecutive patients visiting our preoperative evaluation clinic were surveyed asked whether they had made decisions regarding resuscitation rate their agreement several...

What every intensivist should know about prognostic scoring systems and risk-adjusted mortality COMMENTARYIn the practice of medicine, multiple scores have been developed to quantify disease severity, assess prognosis, guide therapeutic interventions.The Glasgow Coma Scale, Model for End Stage Liver Disease (MELD), American Society Anesthesiologists Physical Status Classification are but a few examples.3)(4)(5)(6)(7) Scoring may be generic or disease-specific, used cohort analysis individual...

At the beginning of each academic year in July, inexperienced residents and fellows begin to care for patients. This inexperience can lead poor patient outcome, especially patients admitted intensive unit (ICU). The objective this study was determine impact July ICU admission on outcome.Retrospective, cohort study.Academic, tertiary medical center.Patients from October 1994 through September 2002.None.Demographics, Acute Physiology Chronic Health Evaluation (APACHE) III score predicted...

Objective: To determine the impact of nighttime transfer patients from intensive care unit (ICU) on clinical outcome. Design: Retrospective, observational. Setting: Three units a tertiary medical center. Patients: We used prospectively collected information Acute Physiology and Chronic Health Evaluation III database 11,659 transferred ICU to regular ward. Interventions: None. Measurements Main Results: Based time transfer, who were ward categorized into daytime (7:00 am–6:59 pm) pm–6:59 am)...

Objectives: To determine the impact of rapid response team implementation on outcome patients transferred from regular hospital ward and nonward locations to ICU. Design: Retrospective before–after cohort study. Setting: The study was performed in two ICUs, one surgical medical, a tertiary medical center. Patients: We included 4,890 ICUs 15,855 admitted locations. Interventions: None. Measurements Main Results: Data each patient were abstracted Acute Physiology Chronic Health Evaluation III...