A5070568582- Pain Mechanisms and Treatments
- Pediatric Pain Management Techniques
- Musculoskeletal pain and rehabilitation
- Anesthesia and Sedative Agents
- Pain Management and Opioid Use
- Anesthesia and Neurotoxicity Research
- Nicotinic Acetylcholine Receptors Study
- Cardiac, Anesthesia and Surgical Outcomes
- Pharmacology and Obesity Treatment
- Spine and Intervertebral Disc Pathology
- Hereditary Neurological Disorders
- Occupational Health and Performance
- Neurogenetic and Muscular Disorders Research
- Contact Dermatitis and Allergies
- Congenital Anomalies and Fetal Surgery
- Muscle activation and electromyography studies
- Oral health in cancer treatment
- Palliative Care and End-of-Life Issues
- Substance Abuse Treatment and Outcomes
- Transcranial Magnetic Stimulation Studies
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Pain Management and Treatment
- Cerebral Palsy and Movement Disorders
- Pharmaceutical studies and practices
Harvard University
2015-2025
Boston Children's Hospital
2015-2025
Pain and Rehabilitation Medicine
2020
Boston Children's Museum
2020
Inflexxion (United States)
2013
Neosaxitoxin (NeoSTX) is a site-1 sodium channel blocker that produces prolonged local anesthesia in animals and humans. Under Food Drug Administration-approved phase 1 Investigational New trial, the authors evaluated safety efficacy of NeoSTX alone combined with 0.2% bupivacaine (Bup) without epinephrine.The conducted double-blind, randomized, controlled trial involving healthy male volunteers aged 18 to 35 yr receiving two 10-ml subcutaneous injections. Control sites received Bup. In part...
Visitors to a popular online drug forum completed an survey between November 2011 and January 2012, which covered (1) demographic characteristics, (2) substance use (including nonmedical prescription opioid use), (3) activity, (4) harm reduction beliefs. The study sample (N = 897) primarily included Caucasian males in their twenties from the United States, Kingdom, Australia, Canada. practice of was overwhelmingly endorsed by participants. Current users reported more activity forums past...
Summary Background Deep anesthesia in adults may be associated with electroencephalographic ( EEG ) suppression and higher rates of postoperative complications. Little is known about the impact anesthetic depth on short‐ or long‐term outcomes pediatrics. Brain activity monitoring complement clinical signs depth. This prospective observational study aimed to assess frequency degree profound using multichannel children during sevoflurane general anesthesia. Methods Children aged 0–40 months...
Evidence supports treatment of pediatric complex regional pain syndromes (CRPS) with physical and occupational therapy cognitive-behavioral therapy. Some patients have persistent and/or limb dysfunction despite these treatments. We performed a retrospective study CRPS treated by continuous epidural or peripheral perineural local anesthetic infusions along inpatient rehabilitation at Boston Children's Hospital.After approval from the institutional review board, electronic medical records were...
The management of pediatric pain typically consists individualized treatment plans and interventions that have not been systematically evaluated. There is an emerging need to create systems can support the translation clinical discoveries, facilitate assessment current interventions, improve collection patient-centered data beyond routine information. We present development repository, a custom-built system developed at Boston Children's Hospital by multidisciplinary service. Repository...
Abstract Background Anaphylaxis to propofol is rare; however, providers face a clinical quandary as medication warnings still exist regarding administration egg‐, soy‐, and peanut‐allergic patients. Aims The primary aim evaluated the rate of allergic reactions during propofol‐containing anesthesia in patients listed egg, soy, or peanut compared with nonallergic who received propofol. secondary relationship between food allergy history testing data. Methods A retrospective chart review...
Background Tactile sensitivity in the infant period is poorly characterized, particularly among children with prior surgery, anaesthesia or critical illness. The study aims were to investigate tactile of foot and associated coordination lower limb motor movement typically developing infants without hospital experience, develop feasible bedside sensory testing protocols. Materials methods A prospective, longitudinal 69 at 2 4 months-old, admission. Mechanical stimuli applied graded innocuous...
Abstract Quantitative sensory testing (QST) is a set of methods for quantifying somatosensory functioning. Limitations laboratory-based QST (LQST) include high cost, complexity in training, lack portability, and time requirements testing. Translating to home setting could facilitate future research clinical care. The objective this study was develop (HQST) tool-kit that cost-effective, easy use, detects changes pain processing. Thirty-two young healthy adults underwent on their nondominant...
Context. In a previous retrospective study, cancer pain management was effective in 47.5% of cohort assessed after 3 months clinic at Siriraj Hospital. New guidelines were established, including multidisciplinary approach, availability interventions, and palliative care referral. Objectives. The objective to examine the effectiveness updated approach. Methods. With IRB approval, outpatients with enrolled from January December 2018. Assessments recorded baseline three consecutive visits (BL,...
Erythromelalgia is a descriptive term for severe burning pain and erythema in the distal extremities relieved by cold exacerbated heat. Pediatric case series to date are relatively small. We extracted analyzed medical record data 42 pediatric patients describe clinical characteristics, associated conditions, responses treatments. Informed consent was obtained according an IRB-approved protocol that included gene discovery. Three had confirmed Nav1.7 sodium channelopathies, with six...
( Anesthesiology. 2015;123(4):873–885) Prolonged local anesthesia has been successfully achieved in both animals and humans using a site-1 sodium channel blocker called Neosaxitoxin (NeoSTX). The purpose of this study was to assess the safety NeoSTX when administered through injection by itself, combined with bupivacaine, bupivacaine epinephrine. authors hypothesized that drug would prove safe from cardiovascular, neuromuscular, respiratory standpoint. A secondary aim for evaluate...
Chronic low back pain (CLBP) is common among adolescent athletes.[1 2][1] Extension-related axial CLBP can arise from posterior elements of the spine, including lumbar zygapophyseal/facet joints. Lumbar medial branch blocks (LMBB) are used diagnostically and therapeutically in adults to treat facet