A5051648635- Pediatric Pain Management Techniques
- Pain Mechanisms and Treatments
- Musculoskeletal pain and rehabilitation
- Anesthesia and Pain Management
- Pain Management and Placebo Effect
- Scoliosis diagnosis and treatment
- Pharmacology and Obesity Treatment
- Heart Rate Variability and Autonomic Control
- Muscle activation and electromyography studies
- Health, Environment, Cognitive Aging
- Psychosomatic Disorders and Their Treatments
- Functional Brain Connectivity Studies
- Hereditary Neurological Disorders
- Adenosine and Purinergic Signaling
- Ion channel regulation and function
- Intensive Care Unit Cognitive Disorders
- Genetics and Neurodevelopmental Disorders
- Anesthesia and Sedative Agents
- Occupational Health and Performance
- Pain Management and Opioid Use
- Mindfulness and Compassion Interventions
- EEG and Brain-Computer Interfaces
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Transcranial Magnetic Stimulation Studies
Harvard University
2023-2025
Boston Children's Hospital
2023-2025
McGill University
2018-2023
Shriners Hospitals for Children - Canada
2018-2023
Brain Tumour Foundation of Canada
2023
Brain Canada Foundation
2023
Montreal Children's Hospital
2023
McGill University Health Centre
2018-2022
Objectives . Acute pain trajectories are associated with long-term outcomes such as persistent and functional disability in adults. However, there limited data on acute postoperative the pediatric population. The aims of this study were to investigate trajectories, their predictors, impact long- term adolescents idiopathic scoliosis. Methods We evaluated preoperative intensity, use analgesics, psychosocial measures physical functioning scheduled undergo spinal fusion, average 6-hour...
Abstract Children with Christianson syndrome (CS), an X-linked neurodevelopmental disorder caused by loss-of-function mutations in the alkali cation/proton exchanger SLC9A6/NHE6, display severe cognitive impairments, mutism, and sensory abnormalities such as hyposensitivity to pain. However, it is unclear whether these children other their pain result of elevated threshold or a complete insensitivity To better characterize this disorder, we used combination mouse model CS questionnaires...
A major limitation in treatment outcomes for chronic pain is the heterogeneity of population. Therefore, a personalized approach to assessment and children adolescents with conditions needed. The objective study was subgroup pediatric patients MSK that will be phenotypically different from each other based on their psychosocial profile, somatosensory function, modulation.This observational cohort recruited 302 (10-18 years) musculoskeletal 80 age-matched controls. After validated self-report...
Background: The days following surgery are a critical period where the use of opioids predicts long-term outcomes in adults. It is currently unknown as to whether opioid consumption throughout acute postoperative associated with pediatric patients. aims this study were characterize trajectories period, identify predictors trajectory membership and determine associations between patient outcomes. Materials methods: Medication use, pain mental health status assessed at baseline adolescents...
Purpose: Nociplastic pain distinguishes individuals with and hypersensitivity in body regions apparently normal tissues, without any signs of neuropathy, but contribution central and/or peripheral sensitization. There is a lack literature describing nociplastic the pediatric population. The objective this study was to investigate differences between patients compared non-nociplastic pain. Patients Methods: This included 414 followed at an interdisciplinary centre for complex All underwent...
Abstract Background Identifying subgroups with different clinical profiles may inform tailored management and improve outcomes. The objective of this study was to identify psychosocial psychophysical children adolescents chronic back pain. Methods One hundred ninety‐eight patients pain were recruited for the study. Pain assessment mainly conducted in form an interview use validated pain‐related questionnaires assessing their factors disability. All underwent mechanical thermal quantitative...
We assessed the potential of using EEG to detect cold thermal pain in adolescents with and without chronic musculoskeletal pain.Thirty-nine healthy controls (15.2 ± 2.1 years, 18 females) 121 participants (15.0 2.0 100 females, 85 experiencing ≥12-months) had 19-channel recorded at rest throughout a cold-pressor task (CPT). Permutation entropy, directed phase lag index, peak frequency, binary graph theory features were calculated across 10-second epochs (Healthy: 292 baseline / 273 CPT...
Abstract Introduction: When investigating the role of facilitatory and inhibitory pain mechanisms such as conditioned modulation (CPM) temporal summation (TSP), it is important to take both into consideration in a single experimental model provide most information on subgroups patients. Therefore, objective this study was identify large population pediatric patients with chronic based their compare them control subjects. Methods: Five hundred twenty-one female subjects 147 male between 8 21...
Postoperative pain cannot be measured accurately among many children with intellectual and developmental disabilities, resulting in underrecognition or delay recognition of pain. The Critical-Care Pain Observation Tool (CPOT) is a assessment tool that has been widely validated critically ill postoperative adults.The objective this study was to validate the CPOT for use pediatric patients able self-report undergoing posterior spinal fusion surgery.Twenty-four (10-18 years old) scheduled...
ABSTRACT Background: Bibliometrics methods have allowed researchers to assess the popularity of brain research through ever-growing number brain-related papers. While many topics been covered by previous studies, there is no comprehensive overview evolution and its various specialties funding practices over a long period time. Objective: This paper aims (1) determine how has evolved time in terms papers, (2) countries' relative absolute positioning papers impact, (3) those trends vary area....
This article investigates the benefits of adopting qualitative and quantitative sensory testing (QQST) in assessment, with a focus on understanding neuropathic pain. The innovative QQST method combines participant experiences psychophysical measurements, offering more varied interpretation abnormalities normal function. also explores steps for optimization by identifying signs standardizing data collection. By leveraging inherent subjectivity test design responses, contributes to holistic...
Abstract Quantitative sensory testing (QST) is a set of methods for quantifying somatosensory functioning. Limitations laboratory-based QST (LQST) include high cost, complexity in training, lack portability, and time requirements testing. Translating to home setting could facilitate future research clinical care. The objective this study was develop (HQST) tool-kit that cost-effective, easy use, detects changes pain processing. Thirty-two young healthy adults underwent on their nondominant...
Abstract Introduction: The pathophysiology of pediatric musculoskeletal (MSK) pain is unclear, contributing to persistent challenges its management. Objectives: This study hypothesizes that children and adolescents with chronic MSK (CPs) will show differences in electroencephalography (EEG) features at rest during thermal modalities when compared age-matched controls. Methods: One hundred forty-two CP patients 45 healthy controls (HCs) underwent a standardized tonic heat cold stimulations,...
Pain catastrophizing in children and adolescents has been associated to unfavorable postsurgical outcomes. However, pain is rarely measured throughout the perioperative period. Using a prospective longitudinal approach, present study aimed identify how changes over period pediatric surgical patients with adolescent idiopathic scoliosis.Adolescent undergoing spinal fusion surgery completed Catastrophizing Scale for Children additional questionnaires assess intensity, state trait anxiety,...
Erythromelalgia is a descriptive term for severe burning pain and erythema in the distal extremities relieved by cold exacerbated heat. Pediatric case series to date are relatively small. We extracted analyzed medical record data 42 pediatric patients describe clinical characteristics, associated conditions, responses treatments. Informed consent was obtained according an IRB-approved protocol that included gene discovery. Three had confirmed Nav1.7 sodium channelopathies, with six...