A5073638457- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Child and Adolescent Psychosocial and Emotional Development
- Autism Spectrum Disorder Research
- Neural dynamics and brain function
- Infant Development and Preterm Care
- Stress Responses and Cortisol
- Child Abuse and Trauma
- Child Development and Digital Technology
- Mental Health Research Topics
- Language Development and Disorders
- Attention Deficit Hyperactivity Disorder
- Early Childhood Education and Development
- Neuroendocrine regulation and behavior
- Anesthesia and Sedative Agents
- Maternal Mental Health During Pregnancy and Postpartum
- Family and Disability Support Research
- Anesthesia and Neurotoxicity Research
- Birth, Development, and Health
- Infant Health and Development
- Neonatal and fetal brain pathology
- Genetics and Neurodevelopmental Disorders
- Cognitive Abilities and Testing
- Child Welfare and Adoption
- Neuroscience and Music Perception
Northeastern University
2020-2025
Universidad del Noreste
2021-2024
Boston University
2024
Boston Children's Hospital
2017-2023
Boston Children's Museum
2017-2022
Harvard University
2017-2021
Harvard University Press
2018
Columbia University
2015-2017
University of California, Los Angeles
2012-2017
Harvard College Observatory
2013
Significance Early adversity has profound and lasting effects on neurodevelopment emotional behavior. Under typical environmental conditions, prefrontal cortex connections with the amygdala are immature during childhood become adult-like adolescence. Rodent models show that maternal deprivation accelerates this development as an ontogenetic adaptation to adversity. Here, we demonstrate that, in rodent, children who experienced early exhibit emergence of mature amygdala–prefrontal...
Electroenchephalography (EEG) recordings collected with developmental populations present particular challenges from a data processing perspective. These EEGs have high degree of artifact contamination and often short recording lengths. As both sample sizes EEG channel densities increase, traditional approaches like manual rejection are becoming unsustainable. Moreover, such subjective preclude standardized metrics quality, despite the heightened importance measures for rates initial...
Mature amygdala-prefrontal circuitry regulates affect in adulthood but shows protracted development. In altricial and semialtricial species, caregivers provide potent regulation when mature neurocircuitry is absent. The present investigation examined a potential mechanism through which regulatory influences childhood. Children, not adolescents, showed evidence of maternal buffering, such that stimuli suppressed amygdala reactivity. the absence stimuli, children exhibited immature...
An aim of autism spectrum disorder (ASD) research is to identify early biomarkers that inform ASD pathophysiology and expedite detection. Brain oscillations captured in electroencephalography (EEG) are thought be disrupted as core pathophysiology. We leverage longitudinal EEG power measurements from 3 36 months age infants at low- high-risk for test how when distinguishes risk diagnosis by 3-years. Power trajectories across the first year, second or three years postnatally were submitted...
Current research suggests that autism spectrum disorder (ASD) is characterized by asynchronous neural oscillations. However, it unclear whether changes in oscillations represent an index of the or are shared more broadly among both affected and unaffected family members. Additionally, remains how early these differences emerge development they remain constant change over time. In this study we examined developmental trajectories spectral power infants at high- low-risk for ASD. Spectral was...
Early institutional care can be profoundly stressful for the human infant, and, as such, lead to significant alterations in brain development. In animal models, similar variants of early adversity have been shown modify amygdala–hippocampal–prefrontal cortex development and associated aversive learning. The current study examined this rearing aberration Eighty-nine children adolescents who were either previously institutionalized (PI youth; <i>N</i> = 46; 33 females 13 males; age range, 7–16...
Electroencephalography (EEG) offers information about brain function relevant to a variety of neurologic and neuropsychiatric disorders. EEG contains complex, high-temporal-resolution information, computational assessment maximizes our potential glean insight from this information. Here we present the Batch Automated Processing Platform (BEAPP), an automated, flexible processing platform incorporating freely available software tools for batch multiple files across steps. BEAPP does not...
Although decades of research have shown associations between early caregiving adversity, stress physiology and limbic brain volume (e.g., amygdala, hippocampus), the developmental trajectories these phenotypes are not well characterized. In current study, we used an accelerated longitudinal design to assess development physiology, hippocampal following institutional care. Previously Institutionalized (PI; N = 93) comparison (COMP; 161) youth (ages 4-20 years old) completed 1-3 waves data...
Importance Research evidence is mounting for the association between infant screen use and negative cognitive outcomes related to attention executive functions. The nature, timing, persistence of time exposure on neural functions are currently unknown. Electroencephalography (EEG) permits elucidation correlates associated with impairments. Objective To examine associations time, EEG markers, school-age using mediation analysis structural equation modeling. Design, Setting, Participants This...
Interpretations of facial expressions with ambiguous valence, such as surprised (which can be perceived having positive or negative valence), reveal individual differences in positivity-negativity biases. Negative interpretations are first and fast, but this initial negativity default overridden by regulatory control processes that result interpretations. We tested the hypothesis examining biases during development. hypothesized childhood, mode would more evident than adulthood and, a group,...
ABSTRACT Traditional conceptualizations of early adversity characterize behavioral outcomes as maladaptive. However, conditional adaptation theory proposes that differing phenotypes following experience are appropriate for the expected environment (e.g., behaviors likely to result in best outcome based on environmental expectations). In present study, youth with ( n = 46) and without 91) a history previous institutionalization completed laboratory‐based experimental paradigm which...
Abstract Early caregiving adversity is associated with increased risk for social difficulties. The ventral striatum and corticostriatal circuitry, which have demonstrated vulnerability to early exposures adversity, are implicated in many aspects of behavior, including play, aggression, valuation stimuli across development. Here, we used resting-state functional magnetic resonance imaging assess the degree was altered coritocostriatal resting connectivity previously institutionalized youth (...
Abstract Gastrointestinal and mental disorders are highly comorbid, animal models have shown that both can be caused by early adversity (e.g., parental deprivation). Interactions between the brain bacteria live within gastrointestinal system (the microbiome) underlie adversity–gastrointestinal–anxiety interactions, but these links not been investigated during human development. In this study, we utilized data from a population of 344 youth (3–18 years old) who were raised with their...
Although the functional architecture of brain is indexed by resting-state connectivity networks, little currently known about mechanisms through which these networks assemble into stable mature patterns. The current study posits and tests long-term phasic molding hypothesis that are gradually shaped recurring stimulus-elicited across development examining how both connections human emerge over at systems level. Using a sequential design following 4- to 18-year-olds 2 year period, we examined...