A5069437689- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Musculoskeletal pain and rehabilitation
- Medical Imaging and Analysis
- Cervical and Thoracic Myelopathy
- Shoulder Injury and Treatment
- Scoliosis diagnosis and treatment
- Pelvic and Acetabular Injuries
- Osteoarthritis Treatment and Mechanisms
- Anesthesia and Pain Management
- Orthopaedic implants and arthroplasty
- Veterinary Orthopedics and Neurology
- Management of metastatic bone disease
- Spinal Hematomas and Complications
- Nerve Injury and Rehabilitation
- COVID-19 and healthcare impacts
- Infectious Diseases and Tuberculosis
- Pregnancy-related medical research
- Hip disorders and treatments
- Plant Toxicity and Pharmacological Properties
- Spondyloarthritis Studies and Treatments
- Pain Mechanisms and Treatments
- Bone Tissue Engineering Materials
- Healthcare and Venom Research
- Telemedicine and Telehealth Implementation
Rush University Medical Center
2016-2025
University of California, San Diego
2024
Smith Family
2023
Smith & Nephew (Switzerland)
2023
Hospital for Special Surgery
2023
North American Spine Society
2023
Cervical Spine Research Society
2013-2023
Stryker (United States)
2011-2023
Stryker (Switzerland)
2023
Arthrex (United States)
2023
Surgery for spinal stenosis is widely performed, but its effectiveness as compared with nonsurgical treatment has not been shown in controlled trials.
Study Design. A biomechanical study was performed using cadaveric cervical spine specimens. Objective. To determine the effect of fusion on adjacent-level intradiscal pressure. Summary Background Data. Clinical studies have reported that patients with spinal are at greater risk pathology and early disc degeneration adjacent levels. It is hypothesized eliminating motion one level leads to hypermobility increased forces levels, thus increasing rate degeneration. Methods. Six specimens were...
In Brief Study Design. An in vivo study to radiographically and histologically assess a new method of induction disc degeneration. Objective. To establish reproducible rabbit model degeneration by puncturing the anulus with needles defined gauges compare it classic stab model. Summary Background Data. New treatment approaches are great interest. Although animal models for degenerative disease exist, quantitative measurement progression remains difficult. A reproducible, progressive model,...
Study Design. A biomechanical and imaging study of human cadaveric spinal motion segments. Objective. To investigate the effect both disc degeneration facet joint osteoarthritis on lumbar segmental motion. Summary Background Data. Spinal includes osteoarthritic changes as well degeneration. Disc has been reported to be associated with The association characteristics combined influence not yet investigated. Methods. total 110 segments (52 female, 58 male) from 44 spines were studied (mean age...
In Brief Study Design. Randomized trial and concurrent observational cohort study. Objective. To compare 4 year outcomes of surgery to nonoperative care for spinal stenosis. Summary Background Data. Surgery stenosis has been shown be more effective compared treatment over 2 years, but longer-term data have not analyzed. Methods. Surgical candidates from 13 centers in 11 US states with at least 12 weeks symptoms confirmatory imaging were enrolled a randomized (RC) or (OC). Treatment was...
We used computerized tomographic scans and subsequent dissections to evaluate the position of ninety pedicle screws that had been inserted bilaterally into fourth through twelfth thoracic vertebrae five fresh-frozen cadavera. The by experienced spine surgeons without use radiographs or imaging studies. Of screws, thirty-seven were found have penetrated cortex pedicle. Twenty-one medial entered spinal canal, sixteen lateral cortex. aorta esophagus at greatest risk for injury after advancement...
A cadaveric study was done to investigate the variability of interfacet distances from C3 C7, learn pedicle morphology at C7-T2, and determine potential dangers plate-screw osteosynthesis technique cervical spine. Twenty-two cadavers were dissected C2 C7 expose lateral masses nerve roots. The center mass next vary widely among different individuals, ranging 9 mm 16 (average, 13 mm). new plate design is necessary better accommodate differences in patients levels. second part involved 11...
This study analyzed the fusion results of an allograft-demineralized bone matrix composite versus autograft in a prospective series patients undergoing surgery for cervical disc disease.To determine rates anterior as compared with gold standard autograft.For fusion, use freeze-dried allograft is well documented literature, citing its effectiveness and inferior rates. The demineralized conjunction has not been reported.This was done fashion two medical centers. One group received from iliac...
Study Design A cadaveric study was done to analyze the dimensional changes in spinal canal and intervertebral foramen of lumbar spine with flexion extension movements. Objectives To investigate relationship between movements morphologic foramen. Summary Background Data Previous studies have reported that dimensions may change significantly motion. The purpose this assess quantitative segmental flexion-extension Methods Nineteen fresh spines yielding 25 motion segments were used. frozen then...
In vivo study of the effect injection osteogenic protein-1 (OP-1) on a rabbit anular needle puncture model intervertebral disc (IVD) degeneration.To radiographic, magnetic resonance imaging (MRI), biochemical, and histologic changes in IVD after OP-1 into nucleus pulposus degeneration model.Growth factors, such as OP-1, have ability to stimulate synthesis proteoglycans collagen vitro. The normal has increased height proteoglycan content anulus fibrosus pulposus. However, our knowledge, no...
Degenerative processes in the disc and facet joints affect stability of motion segment. The exact relations among degeneration, joint osteoarthritis, kinematics segment are not well defined literature. Magnetic resonance imaging functional radiography lumbar spine were analyzed to examine segmental instability, degeneration patients with degenerative disorders spine. Seventy consecutive (mean age, 46 years) had both magnetic flexion extension radiographs instability was classified into...
In Brief Study Design. A review of 66 consecutive patients at a single institution who underwent one-level anterior cervical discectomy and fusion (ACDF) with rigid plate fixation allograft or autograft. Objectives. To address the efficacy to autograft primary respect rate secondary attention risk factors clinical outcome in undergoing ACDF fixation. Summary Background Data. Although is considered gold standard achieving optimal fusion, when compared noninstrumented plated nonplated...
In Brief Study Design. A study of the disc height and biochemical changes in rabbit intervertebral after injection osteogenic protein-1 into nucleus pulposus. Objectives. To evaluate vivo effects administered intradiscally to rabbits. Summary Background Data. Growth factors, such as transforming growth factor-β, have ability stimulate synthesis proteoglycan collagen vitro. No attempts yet been made determine these factors an model. Methods. Twenty-four New Zealand adolescent white rabbits...
One hundred lumbar intervertebral foramina from eighteen spines of fresh cadavera were studied to assess the relationship between compression nerve root and height disc morphological characteristics foramen as determined on cryomicrotome sections. The critical posterior foraminal that associated with entrapment determined. Significant positive correlations demonstrated height, cross-sectional area for four levels second first sacral vertebrae. Nerve-root was evident in twenty-one 100...
In vitro studies on the effects of recombinant human growth and differentiation factor-5 (rhGDF-5) matrix metabolism bovine intervertebral disc cells an in vivo study effect rhGDF-5 rabbit anular puncture model.To determine reparative capacity disc.The rhGDF-5, a crucial protein developing musculoskeletal system, repair degenerated remain unidentified.In vitro, nucleus pulposus anulus fibrosus were cultured with or without (100 200 ng/mL). On days 7, 14, 21, contents deoxyribonucleic acid...