A5002847881- Spine and Intervertebral Disc Pathology
- Orthopaedic implants and arthroplasty
- Spinal Dysraphism and Malformations
- Medical Imaging and Analysis
- Spinal Fractures and Fixation Techniques
- Musculoskeletal pain and rehabilitation
- Bone Tissue Engineering Materials
- Bone fractures and treatments
- Cervical and Thoracic Myelopathy
- Bone Metabolism and Diseases
- Scoliosis diagnosis and treatment
- TGF-β signaling in diseases
- Dental Implant Techniques and Outcomes
- Anesthesia and Pain Management
- Pelvic and Acetabular Injuries
- Connective tissue disorders research
- Musculoskeletal Disorders and Rehabilitation
- Bone health and treatments
- Virus-based gene therapy research
- Bone health and osteoporosis research
- Hip disorders and treatments
- Medical and Biological Sciences
- Shoulder Injury and Treatment
- Mesenchymal stem cell research
- Bone and Dental Protein Studies
Emory University
2014-2024
Veterans Health Administration
1998-2021
Emory University Orthopaedics and Spine Hospital
2009-2021
Brandenburg University of Technology Cottbus-Senftenberg
2021
Danish Diabetes Academy
2018
Atlanta VA Medical Center
1999-2014
Medical Education Institute
2012-2014
Behörde für Gesundheit und Verbraucherschutz
2014
Food and Drug Administration
2014
United States Food and Drug Administration
2014
The objective of this NIH Consensus Statement is to inform the biomedical research and clinical practice communities results Development Conference on Osteoporosis Prevention, Diagnosis, Therapy. statement provides state-of-the-art information presents conclusions recommendations consensus panel regarding these issues. In addition, identifies those areas study that deserve further investigation. target audience clinicians for includes, but not limited to, family practitioners, internists,...
Previous investigations with plain radiography, myelography, and computed tomography have shown that degenerative disease of the cervical spine frequently occurs in absence clinical symptoms. We studied magnetic resonance-imaging scans sixty-three volunteers who had no history symptoms indicative disease. The were mixed randomly thirty-seven patients a symptomatic lesion spine, all interpreted independently by three neuroradiologists. as demonstrating an abnormality 19 per cent asymptomatic...
We performed magnetic resonance imaging on sixty-seven individuals who had never low-back pain, sciatica, or neurogenic claudication. The scans were interpreted independently by three neuro-radiologists no knowledge about the presence absence of clinical symptoms in subjects. About one-third subjects found to have a substantial abnormality. Of those less than sixty years old, 20 per cent herniated nucleus pulposus and one spinal stenosis. In group that was old older, findings abnormal 57...
Surgery for spinal stenosis is widely performed, but its effectiveness as compared with nonsurgical treatment has not been shown in controlled trials.
ContextLumbar diskectomy is the most common surgical procedure performed for back and leg symptoms in US patients, but efficacy of relative to nonoperative care remains controversial.ObjectiveTo assess surgery lumbar intervertebral disk herniation.Design, Setting, PatientsThe Spine Patient Outcomes Research Trial, a randomized clinical trial enrolling patients between March 2000 November 2004 from 13 multidisciplinary spine clinics 11 states. Patients were 501 candidates (mean age, 42 years;...
A prospective randomized clinical study was conducted.To determine whether the dose and carrier that were successful in rhesus monkeys could induce consistent radiographic spine fusion humans.Preclinical studies have demonstrated recombinant human bone morphogenetic protein-2 (rhBMP-2), an osteoinductive protein, is at generating rabbits monkeys.For this study, 25 patients undergoing lumbar arthrodesis (1:2:2 ratio) based on technique: autograft/Texas Scottish Rite Hospital (TSRH) pedicle...
Study Design. A prospective randomized controlled human clinical pilot trial. Objectives. To determine the feasibility of using rhBMP-2/collagen as a substitute for autogenous bone graft inside interbody fusion cages to achieve arthrodesis in humans. Summary Background Data. Preclinical studies have shown rhBMP-2 be an effective graft, but there are no date documenting such efficacy spine fusion. Methods. Fourteen patients with single-level lumbar degenerative disc disease refractory...
In Brief Study Design. Randomized trial and concurrent observational cohort study. Objective. To compare 4 year outcomes of surgery to nonoperative care for spinal stenosis. Summary Background Data. Surgery stenosis has been shown be more effective compared treatment over 2 years, but longer-term data have not analyzed. Methods. Surgical candidates from 13 centers in 11 US states with at least 12 weeks symptoms confirmatory imaging were enrolled a randomized (RC) or (OC). Treatment was...
Tumor necrosis factor-α (TNF-α) has a key role in skeletal disease which it promotes reduced bone formation by mature osteoblasts and increased osteoclastic resorption. Here we show that TNF inhibits differentiation of from precursor cells. TNF-α treatment fetal calvaria cells, spontaneously differentiate to the osteoblast phenotype over 21 days, inhibited as shown multilayered, mineralizing nodules decreased secretion skeletal-specific matrix protein osteocalcin. The effect was dose...
In 1989, a group of sixty-seven asymptomatic individuals with no history back pain underwent magnetic resonance imaging the lumbar spine. Twenty-one subjects (31%) had an identifiable abnormality disc or spinal canal. current study, we investigated whether findings on scans spine that been made in 1989 predicted development low-back these subjects.A questionnaire concerning and duration over seven-year period was sent to from study. A total fifty completed returned questionnaire. repeat scan...
We analyzed the cases of seventy-three patients who were managed over a twenty-year period for rheumatoid involvement cervical spine and followed minimum two years, with an average follow-up seven years. A neurological deficit did not develop in thirty-one (Ranawat et al. Class I) paralysis developed remaining forty-two patients: II eleven III thirty-one. Of whom developed, thirty-five had operative stabilization. Seven soft collar because they refused or medically unable to have operation;...
Various types of cellular injection have become a popular and costly treatment option for patients with knee osteoarthritis despite paucity literature establishing relative efficacy to each other or corticosteroid injections. Here we aimed identify the safety cell injections from autologous bone marrow aspirate concentrate, adipose stromal vascular fraction allogeneic human umbilical cord tissue-derived mesenchymal cells, in comparison (CSI). The study was phase 2/3, four-arm parallel,...
The purpose of this investigation was to develop, characterize, and validate an animal model for lumbar intertransverse process fusion.This study used a rabbit characterize the radiographic, histologic, biomechanical properties spinal fusion healing process.Sixty adult New Zealand white rabbits underwent bilateral posterolateral at L5-L6 using autogenous iliac bone graft. Four were as negative controls: two received graft without decortication transverse process, grafting. Rabbits killed 2,...
The orientation of the lumbar facet joints was studied with magnetic resonance imaging in 140 subjects to determine if there is an association between tropism and intervertebral disc disease or degenerative spondylolisthesis. were divided into four groups: sixty-seven asymptomatic volunteers, forty-six whom did not have a herniated on scans (Group I) twenty-one who II); symptomatic patients had confirmed operatively III); twenty-seven spondylolisthesis at interspace fourth fifth vertebrae...
Study Design. Lumbar intertransverse process arthrodesis using recombinant human bone morphogenetic protein-2 was performed in a previously established rabbit model for posterolateral spinal fusion and compared with fusions achieved autogenous graft. Objectives. To qualitatively compare different dosages carriers to determine the efficacy of as graft substitute produce lumbar validated fusion. Summary Background Data. Autogenous considered most successful material used arthrodesis. Problems...
Background: The SPORT (Spine Patient Outcomes Research Trial) reported favorable surgery outcomes over 2 years among patients with stenosis and without degenerative spondylolisthesis, but the economic value of these surgeries is uncertain. Objective: To assess short-term cost-effectiveness spine relative to nonoperative care for alone spondylolisthesis. Design: Prospective cohort study. Data Sources: Resource utilization, productivity, EuroQol EQ-5D score measured at 6 weeks 3, 6, 12, 24...
The purpose of this study was to examine the mechanical necessity using a syndesmosis screw supplement rigid internal fixation fibula and medial malleolus in treatment pronation-external rotation fractures. legs thirty embalmed five fresh cadavera were dissected mounted through tibia frame so that multiple radiographs could be made with constant relationship between specimen x-ray apparatus. A standardized load applied foot, widening studied on mortise after each experimental step. On basis...
Study Design. A nonhuman primate lumbar intertransverse process arthrodesis model was used to evaluate recombinant human bone morphogenetic protein 2 (rhBMP-2) in a hydroxyapatite–tricalcium phosphate (HA-TCP) carrier as complete graft substitute. Objectives. To assess the ability of ceramic material serve for various doses rhBMP-2 substitute posterolateral spinal fusion after laminectomy. Summary Background Data. The reported nonunion rates spine with autogenous iliac crest range from...
Study Design An animal model of posterior lateral intertransverse process fusion healing in the face systemic nicotine. Objectives To evaluate effect nicotine on success spinal and its biomechanic properties a an model. Summary Background Data Clinical observations suggested that cigarette smoking interferes with bony fusion. No direct link has been made to implicate as cause for impaired fusions or fractures. Methods Twenty-eight adult female New Zealand white rabbits underwent single level...
Anterior lumbar interbody arthrodesis is commonly performed for conditions involving infection, deformity, and instability. The purpose of this investigation was to determine the effective dose recombinant human bone morpho-genetic protein-2 (rhBMP-2) as a graft substitute inside titanium threaded fusion cage using nonhuman primate model laparoscopic anterior arthrodesis. Eight adult rhesus monkeys underwent exposure lumbosacral spine followed by insertion hollow cylindrical (Sofamor-Danek,...
The utility or futility of flexion-extension radiographs in the diagnosis lumbar spine segmental instability is a controversial issue. Previous investigations have reported large range normal motion and significant overlap symptomatic asymptomatic patterns. authors' goal was to define lumbosacral vivo using ordinary weight-bearing lateral from 40 volunteers without use computers special X-ray equipment. Calculation dynamic vertebral translation, defined as change relative position flexion...