A5004591797- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Eosinophilic Esophagitis
- Contact Dermatitis and Allergies
- Pediatric health and respiratory diseases
- Adolescent and Pediatric Healthcare
- Transgenic Plants and Applications
- Childhood Cancer Survivors' Quality of Life
- Child and Adolescent Health
- Occupational exposure and asthma
- Microscopic Colitis
- Health and Medical Studies
- Celiac Disease Research and Management
- IL-33, ST2, and ILC Pathways
- Urticaria and Related Conditions
- Respiratory viral infections research
- Pharmaceutical studies and practices
- Chronic Obstructive Pulmonary Disease (COPD) Research
- MicroRNA in disease regulation
- Neonatal Respiratory Health Research
- Mast cells and histamine
- Breastfeeding Practices and Influences
- Infant Health and Development
University Hospital Frankfurt
2016-2025
Goethe University Frankfurt
2016-2025
Klinik und Poliklinik für Kinder- und Jugendmedizin
2016-2024
University College London
2023
Hospital for Sick Children
2023
Great Ormond Street Hospital
2023
University of Toronto
2023
Center for Children
2021
Charité - Universitätsmedizin Berlin
2004-2020
Universitätskinderklinik
2016
The persistently high prevalence of allergic diseases in Western industrial nations and the limited possibilities causal therapy make evidence-based recommendations for primary prevention necessary.
No approved treatment for peanut allergy exists children younger than 4 years of age, and the efficacy safety epicutaneous immunotherapy with a patch in toddlers are unknown. We conducted this phase 3, multicenter, double-blind, randomized, placebo-controlled trial involving 1 to 3 age confirmed by food challenge. Patients who had an eliciting dose (the necessary elicit allergic reaction) 300 mg or less protein were assigned 2:1 ratio receive delivered means (intervention group) placebo...
Abstract Adolescent and young adult (AYA) patients need additional support, while they experience the challenges associated with their age. They specific training to learn knowledge skills required confidently self‐manage allergies and/or asthma. Transitional care is a complex process, which should address psychological, medical, educational vocational needs of AYA in developmentally appropriate way. The European Academy Allergy Clinical Immunology has developed clinical practice guideline...
Abstract Genetic factors and mechanisms underlying food allergy are largely unknown. Due to heterogeneity of symptoms a reliable diagnosis is often difficult make. Here, we report genome-wide association study on diagnosed by oral challenge in 497 cases 2387 controls. We identify five loci at significance, the clade B serpin (SERPINB) gene cluster 18q21.3, cytokine 5q31.1, filaggrin gene, C11orf30/LRRC32 locus, human leukocyte antigen (HLA) region. Stratifying results for causative...
The randomized, controlled PALISADE trial demonstrated the benefit of daily oral immunotherapy with Peanut (Arachis Hypogaea) allergen powder-dnfp (PTAH, formerly AR101) in peanut-allergic children and adolescents.ARC004, open-label follow-on study to PALISADE, used 5 dosing cohorts explore PTAH treatment beyond 1 year alternative regimens individuals.Active arm (PTAH-continuing) participants who tolerated 300-mg peanut protein at exit double-blind placebo-controlled food challenge placebo...
Abstract Background The benefit of daily administration Peanut ( Arachis hypogaea ) Allergen Powder‐dnfp (PTAH)—formerly AR101—has been established in clinical trials, but limited data past the first year treatment are available. This longitudinal analysis aimed to explore impact continued PTAH therapeutic maintenance dosing (300 mg/day) on efficacy, safety/tolerability, and food allergy‐related quality life. Methods We present a subset PALISADE‐ARC004 participants (aged 4–17 years) who...
BackgroundA genetic defect in the epidermal barrier protein filaggrin (FLG) plays a major role etiology of eczema and associated allergic airways diseases. However, it is still controversial to what extend loss-of-function (LOF) mutations FLG contribute development persistence food allergies.ObjectivesThis study tested association LOF with reactions diverse foods investigated their potential effect on early allergies.MethodsThis recruited 890 children challenge-proven allergy for German...
Abstract Background Peanut allergy (PA) is a common, potentially life‐threatening and typically lifelong condition with significant burden of illness. However, information lacking on how persons PA (PwPA) their caregivers perceive the psychosocial impact living PA. The Allergy to Peanuts imPacting Emotions And Life 1 (APPEAL‐1) survey, conducted across Europe, investigated experience Here, we report data evaluating PwPA caregivers. Methods study was an online survey in eight European...
Vaccination against coronavirus disease 2019 (COVID-19) began in the United Kingdom and States December 2020. In Kingdom, 3 initial reports of anaphylaxis resulted a temporary embargo on vaccination those with history anaphylaxis.1Raine J. Confirmation guidance to centres managing allergic reactions following COVID-19 Pfizer/BioNTech vaccine (press release). Medicines Healthcare products Regulatory Agency (MHRA). 9,...
This common statement of the American Academy Allergy, Asthma and Immunology (AAAAI) The European Allergy Clinical (EAACI) provides an update 2012 published guidelines on food challenges. equally address challenges in research clinical settings. They first diagnostic tests which can guide decision to conduct a challenge. Safety is prime, various procedures safety issues as well medications potentially involved are extensively discussed. Challenges suggested be conducted with semi-logarithmic...