A5082232958- Asthma and respiratory diseases
- Autoimmune and Inflammatory Disorders Research
- Adolescent and Pediatric Healthcare
- Pediatric health and respiratory diseases
- Pediatric Pain Management Techniques
- Dermatology and Skin Diseases
- Rheumatoid Arthritis Research and Therapies
- Musculoskeletal pain and rehabilitation
- Allergic Rhinitis and Sensitization
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Inflammasome and immune disorders
- Acute Lymphoblastic Leukemia research
- Respiratory and Cough-Related Research
- Kawasaki Disease and Coronary Complications
- Neonatal Respiratory Health Research
- Systemic Lupus Erythematosus Research
- IL-33, ST2, and ILC Pathways
- Gut microbiota and health
- Immune Cell Function and Interaction
- Childhood Cancer Survivors' Quality of Life
- Infant Health and Development
- Spondyloarthritis Studies and Treatments
- Biomedical and Chemical Research
- Immune Response and Inflammation
- Myofascial pain diagnosis and treatment
Mississippi Sports Medicine and Orthopaedic Center
2024
University of Manitoba
2016-2023
Children's Hospital Research Institute of Manitoba
2022-2023
University of Alabama at Birmingham
2022
Hospital for Special Surgery
2021
Cornell University
2021
Weill Cornell Medicine
2021
Hackensack University Medical Center
2021
Western University
2019
Simon Fraser University
2019
<h3>Objective</h3> To evaluate the genetic findings, demographic features and clinical presentation of tumour necrosis factor receptor-associated autoinflammatory syndrome (TRAPS) in patients from Eurofever/EUROTRAPS international registry. <h3>Methods</h3> A web-based registry collected retrospective data on with <i>TNFRSF1A</i> sequence variants inflammatory symptoms. Participating hospitals included paediatric rheumatology centres adult a specific interest diseases. Cases were...
There is convincing evidence from both human and animal studies suggesting that the infant intestinal microbiota plays an important role in regulating immune responses associated with development of allergic diseases. To date there are, however, still no definite bacterial taxa or particular subsets have been consistently diseases, which mainly attributable to methodological dissimilarities between studies. As such a need apply different concepts enhance deeper more refined understanding...
Objective. To compare the 24-month course of health-related quality life (HRQoL) in patients with long-standing RA treated a conventional synthetic (cs) or first, second third biologic (b) DMARD daily rheumatological care.
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by trinucleotide repeat (TNR) expansions. We show here that somatic TNR expansions are significantly reduced in several organs of R6/1 mice lacking exon 2 Nei-like 1 (Neil1) (R6/1/Neil1(-/-)), when compared with R6/1/Neil1(+/+) mice. Somatic expansion measured two different methods, namely mean change and instability index. Reduced more pronounced male R6/1/Neil1(-/-) mice, although also brain regions female In...
The aim was to estimate the impact of individual risk factors and treatment with various disease-modifying antirheumatic drugs (DMARDs) on incidence myocardial infarction (MI) in patients rheumatoid arthritis (RA). We analysed data from 11,285 RA, enrolled prospective cohort study RABBIT, at start biologic (b) or conventional synthetic (cs) DMARDs. A nested case–control conducted, defining MI during follow-up as cases. Cases were matched 1:1 control based age, sex, year enrolment five...
The role of CD8(+) T cells in the development allergic airway disease is controversial. On one hand, are known to inhibit hyperreactivity (AHR) murine models asthma. In humans, IL-10-producing were shown act as regulatory cells, inhibiting both proliferation and cytokine secretion cells. other can promote IL-5-mediated eosinophilic inflammation AHR animal models. To examine this, we investigated during induction allergen-induced demonstrated a protective effect Depletion prior immunization...
To estimate the probability of early remission with conventional treatment for each child juvenile idiopathic arthritis (JIA). Children a low chance may be candidates initial biologics or triple disease-modifying antirheumatic drugs (DMARD). We used data from 1074 subjects in Research Arthritis Canadian emphasizing Outcomes (ReACCh-Out) cohort. The predicted outcome was clinically inactive disease ≥ 6 months starting within 1 year JIA diagnosis patients who did not receive biologic agents...
Background: Research objectives should be focused toward advancing knowledge that has meaningful impact on health. However, research agendas are mostly driven by the health care community, with limited input from patients. Aims: In this study, prioirities of uncertainties for management fibromyalgia (FM) could propel future were identified a defined process using James Lind Alliance Priority Setting Partnership (JLA-PSP) methodology. Methods: As first step, survey was distributed across...
The release of cytokines [interleukin-6 (IL-6), IL-8 and tumor necrosis factor-alpha (TNF-alpha)] by skin cells is involved in the pathogenesis atopic dermatitis (AD).To evaluate effect low-dose cyclosporin A (CyA) on clinical symptoms cytokine secretion severe pediatric AD.Ten children with AD (SCORAD index >50) were treated for 8 weeks CyA. initial dose 2.5 mg/kg/day was titrated to a maximum 5 until SCORAD reduction >or =35% achieved ("treatment response"). After stopping CyA all patients...
Background: Interleukin‐18 (IL‐18) plays an important role in the regulation of TH1 as well TH2 immunologic responses and thus development chronic inflammatory diseases. Positive association studies polymorphisms IL‐18 with different diseases have underlined involvement pathogenetics processes. Our interest was to test for a typical TH1‐mediated disease – juvenile idiopathic arthritis TH2‐mediated bronchial asthma Caucasian children. Methods: We genotyped five that were (−607C, −137C, 113G,...
Due to its distinct pharmacological profile and lower incidence of adverse events compared with other opioids, buprenorphine is considered a safe option for pain substitution therapy. However, despite wide clinical use, little known about the synaptic effects in nociceptive pathways. Here, we demonstrate dose-dependent, bimodal on transmission at C-fiber synapses rat spinal cord dorsal horn vivo. At an analgesically active dose 1500 μg·kg(-1), reduced strength synapses. This depression...
Aim: We investigated the longitudinal development of several antibiotic resistance genes (ARGs) infant gut resistome during first months after birth. Materials & methods: Fecal samples from 120 infants collected at ages 5, 13 and 31 weeks were analyzed subjected to qPCR for detection ARGs. Results: The prevalence ARGs significantly increased ermB, tetM tetQ, while it decreased aac(6′)-aph(2′). Birth mode breastfeeding affected tetQ prevalence. Correlations bacterial taxa suggest that...
To develop Canadian recommendations for the screening, monitoring, and treatment of uveitis associated with juvenile idiopathic arthritis (JIA). Recommendations were developed using Grading Assessment, Development, Evaluation (GRADE)-ADOLOPMENT approach. A working group 14 pediatric rheumatologists, 6 ophthalmologists, 2 methodologists, 3 caregiver/patient representatives reviewed recent American College Rheumatology (ACR)/Arthritis Foundation (AF) worked in pairs to evidence-to-decision...
Osteogenesis imperfecta (OI) and Ehlers–Danlos syndrome (EDS) are variable genetic disorders that overlap in different ways [Cole 1993; Grahame 1999]. Here, we describe a boy presenting with severe muscular hypotonia, multiple fractures, joint hyperflexibility, features compatible mild OI hypermobility type EDS, respectively. By whole exome sequencing, identified both COL1A1 mutation (c.4006‐1G > A) inherited from the patient's mildly affected mother biallelic missense variants TNXB...