A5025018078- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Respiratory and Cough-Related Research
- Neonatal Respiratory Health Research
- Drug-Induced Adverse Reactions
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Contact Dermatitis and Allergies
- Eosinophilic Esophagitis
- Congenital Diaphragmatic Hernia Studies
- IL-33, ST2, and ILC Pathways
- Pharmaceutical studies and practices
- Pediatric health and respiratory diseases
- Congenital Anomalies and Fetal Surgery
- Immune Cell Function and Interaction
- Occupational exposure and asthma
- Neuroscience of respiration and sleep
- Air Quality and Health Impacts
- Infant Nutrition and Health
- Inhalation and Respiratory Drug Delivery
- Respiratory viral infections research
- Olfactory and Sensory Function Studies
- Dermatology and Skin Diseases
- Antibiotics Pharmacokinetics and Efficacy
- Mast cells and histamine
Université Paris Cité
2016-2025
Hôpital Necker-Enfants Malades
2016-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Inserm
2013-2024
Centre National de la Recherche Scientifique
2017-2024
Institut Necker Enfants Malades
2017-2024
Sorbonne Paris Cité
2019-2024
Délégation Paris 5
2013-2024
Urology Team
2024
Lille Inflammation Research International Center
2023
No approved treatment for peanut allergy exists children younger than 4 years of age, and the efficacy safety epicutaneous immunotherapy with a patch in toddlers are unknown. We conducted this phase 3, multicenter, double-blind, randomized, placebo-controlled trial involving 1 to 3 age confirmed by food challenge. Patients who had an eliciting dose (the necessary elicit allergic reaction) 300 mg or less protein were assigned 2:1 ratio receive delivered means (intervention group) placebo...
Perioperative anaphylaxis (PA) is a severe condition that can be fatal, but data on PA mortality are scarce. The aim of this article to review the epidemiology, elicitors and risk factors for identify knowledge gaps areas improvement regarding management PA. affects about 100 cases per million procedures. Mortality rare, estimated at 3 5 procedures, rate higher than other aetiologies, 1.4% 4.8%. However, incomplete. Published mention neuromuscular blocking agents antibiotics, mainly...
Congenital pulmonary malformations (CPM) are mostly recognized on prenatal ultrasound scans. In a minority of cases, they may impair breathing at birth. The factors predictive neonatal respiratory distress not well defined, but an understanding these is essential for decisions concerning the need delivery to take place in tertiary care center. aim this study was identify potential predictors neonates with CPM.We selected cases diagnosis hyperechoic and/or cystic lung lesions from RespiRare,...
Airway wall structure in preschoolers with severe recurrent wheeze is poorly described.To describe airway and inflammation wheeze.Flexible bronchoscopy was performed two groups of wheeze: group 1, less than or equal to 36 months (n = 20); 2, 36-59 29). We assessed inflammation, reticular basement membrane (RBM) thickness, smooth muscle (ASM), mucus gland area, vascularity, epithelial integrity. Comparisons were then made biopsies from 21 previously described schoolchildren asthma (group 3,...
Abstract Background It is unclear whether sensitization patterns differentiate children with severe recurrent wheeze (SRW)/severe asthma (SA) from those non‐severe (NSRW)/non‐severe (NSA). Our objective was to determine can discriminate between the French COBRAPed cohort NSRW/NSA and SRW/SA. Methods IgE 112 components (c‐sIgE) (ImmunoCAP® ISAC) were analyzed in 125 preschools (3–6 years) 170 school‐age (7–12 years). Supervised analyses clustering methods applied identify of among positive...
Few studies have investigated the 24-hour respiratory health effects of personal black carbon (BC) and ultrafine particles (UFP) exposure in schoolchildren. The objective this study was to investigate these associations with lung function children 10-years old without persistent symptoms.We conducted a cross-sectional 305 (147 158 symptoms, respectively) from three European birth-cohorts: PARIS (France) INMA Sabadell Valencia (Spain). Personal measurements concentrations BC UFP were...
The natural history of allergic sensitization in childhood, and its impact on disease development, needs to be clarified. This study aims identify morbidity patterns during the first 8 years life.The was conducted on-going population-based prospective Pollution Asthma Risk: an Infant Study (PARIS) birth cohort. Sensitization profiles were identified by k-means clustering based upon allergen-specific IgE levels measured at 18 months 8/9 years. Allergic latent class analysis symptoms, symptom...
Background Eosinophilic oesophagitis (EoE) is a chronic food allergic disorder limited to oesophageal mucosa whose pathogenesis still only partially understood. Moreover, its diagnosis and follow-up need repeated endoscopies due absence of non-invasive validated biomarkers. In the present study, we aimed deeply describe local immunological molecular components EoE in well-phenotyped children, identify potential circulating EoE-biomarkers. Methods Blood biopsies were collected simultaneously...
Abstract Background A minority of children reporting non‐immediate reactions to beta‐lactams (BLs) are allergic. Allergy workup usually includes late‐reading (48‐72 hours) skin tests (ST) and short (1‐3 days) drug provocation (DPT), regardless the chronology index reaction. The sensitivity hyper‐late‐reading (≥6‐7 ST prolonged DPT for diagnosis hypersensitivity BLs is yet be determined. Objectives To establish diagnostic values in BLs. Methods Prospective assessment with late‐ additional...
Food Protein-Induced Enterocolitis Syndrome (FPIES) is considered to be a non-IgE mediated food allergy. However, its pathogenesis remains poorly understood and biomarkers are lacking. We aimed perform in-depth characterization of humoral cellular immune responses in children with cow's milk (CM)-FPIES investigated whether there FPIES metabolomic signature.Children CM-FPIES control subjects an IgE-mediated CM allergy (IgE-CMA), both avoiding CM, were recruited on the day oral challenge....
Rationale: Although the effects of traffic-related air pollution on respiratory exacerbations have been well documented, its impact lung function in childhood remains unclear.Objectives: Our aim was to investigate associations prenatal, early, and lifetime exposure with at 8–9 years studying possible effect modification by sex, sensitization years, early lower tract infections.Methods: We conducted this study among 788 children from PARIS (Pollution Asthma Risk: an Infant Study) birth...
Abstract Background The Mediterranean diet (MD) has known health benefits, but its specific impact on allergy development is unclear. As part of the PARIS birth cohort follow‐up, we aimed to investigate adherence 8‐year‐old children MD and association with allergic/respiratory morbidity at school age. Methods Diet was assessed using a food frequency questionnaire completed by parents. Adherence based two scores: KIDMED index Score (MDS). Current allergic diseases (asthma, rhinitis, eczema),...
Interest has grown recently in childhood diet's role allergy development. However, the studies focusing on organic food consumption are scarce. We address relationships between such and respiratory/allergic morbidity at school age PARIS (Pollution asthma risk: An infant study) cohort. Diet was assessed using a frequency questionnaire completed by parents 8 years. Dietary patterns were identified cluster analysis based of 30 foods (either or conventional) 19 foods. Associations dietary...
Yin Yang 1 (YY1) is a multifunctional zinc-finger-containing transcription factor that plays crucial roles in numerous biological processes by selectively activating or repressing transcription, depending upon promoter contextual differences and specific protein interactions. In mice, Yy1 null mutants die early gestation whereas hypomorphs at birth from lung defects. We studied how the epithelial-specific inactivation of impacts on development. The mutation epithelium resulted neonatal death...